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Actalipid (Simvastatin)

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Actalipid is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Actalipid is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood.

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Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin


{name} (simvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

{name} is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

{name} is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

{name} is used in adults and children who are at least 10 years old.


Take Actalipid orally. Take Actalipid with or without food. Do not use grapefruit or grapefruit juice while taking Actalipid. Eating grapefruit or drinking grapefruit juice may increase the amount of Actalipid in blood, what may increase the serious side effects. If you want to achieve most effective results do not stop taking Actalipid suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actalipid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Actalipid if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Actalipid. These drugs should not be used while you are taking Actalipid:

cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Actalipid, tell your doctor if you are already using any of these other medicines:

lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Actalipid is safe for you, tell your doctor if you have:

history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Actalipid can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Actalipid if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Actalipid.

Actalipid pregnancy and breastfeeding warnings (more detail)

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Sensitization to tomato peel and pulp extracts in the Mediterranean Coast of Spain: prevalence and co-sensitization with aeroallergens. Cleavage stimulation factor (CstF) is a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role in determining the efficiency of polyadenylation. Nineteen of 30 patients were comfortable wearing the plug, seven patients withdrew from the study because of discomfort, and four had tolerable discomfort and managed to complete the trial protocol. Across the athletic spectrum, many sports fans are fond of chanting that their beloved team is Number One. Human cathelicidin LL-37 enhance the antibiofilm effect of EGCG on Streptococcus mutans. A total of 53 consecutive eyes which underwent phacotrabeculectomy and posterior chamber intraocular lens (PCIOL) were matched and compared with 53 eyes that had trabeculectomy followed by phacoemulsification and posterior chamber intraocular lens (mean interval 3.2 month). We review the usefulness of different cardiac imaging techniques for the diagnosis and management of IE. We studied the effect of antiretroviral therapy (ART) on the quality of life (QOL) of Cubans with HIV/AIDS. However, the regime shift may occur long after the driver has passed the critical point, because of very slow transient dynamics near the critical point.

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Construction of a High-Density American Cranberry (Vaccinium macrocarpon Ait.) Composite Map Using Genotyping-by-Sequencing for Multi-pedigree Linkage Mapping. Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats. This procedure was performed in 55 New Zealand White rabbits under general anesthesia with ketamine/xylazine. We validated a new oral fluid anti-glycoprotein IgG capture assay among survivors from Kerry Town Ebola Treatment Centre and controls from communities unaffected by EVD in Sierra Leone. The aim of the current study is to evaluate the effect of modularity in the tibial tray following the testing standards, using finite element analysis. We use the Environmental Impact Quotient (EIQ) developed by Kovach et al. Iterative searching and screening was conducted to identify sources and clear criteria applied for appraisal of included sources. Accessible xenografts of human synovium in the subcutaneous tissues of the ears of SCID mice.

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Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease. The number of cases of orthopedic surgery is still increasing and postoperative pain management is of great importance for the patients. Precipitation of macroamylase with polyethylene glycol, colourimetric measurement of total amylase activity and immunoinhibition for the determination of pancreatic isoamylase were carried out. This paper extends our previous study of inverse methods of receptivity mapping at low fields, to allow accurate mapping of RF magnetic fields (B(1)) for high-field applications. This proposed evaluation system will provide a transparent assessment for residency training programs and should convert trainees into competent neurosurgeons. To address this issue, first we identified tissue-dependent and differentially methylated regions (T-DMRs) between trophoblast stem (TS) and embryonic stem (ES) cells. To investigate its functions in hESCs, we examined spa-1 expression profiles during hESC differentiation and used RNA interference (RNAi) to downregulate spa-1 in these cells. Pneumocystis jiroveci pneumonia: first documented case in Libreville, Gabon.

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Although multicentre prospective studies are necessary, F-FDG-PET/ceCT appears to be a promising tool in patients affected by peritoneal mesothelioma. This International Multicentre Phase IV Validation Study assessed the QLQ-BIL21 module in 172 patients with cholangiocarcinoma and 91 patients with cancer of the gallbladder. Whereas all rats had six lumbar vertebrae, variable patterns in mice included mostly five vertebrae in DBA/2J, mostly six vertebrae in C57BL/6J, and a mix in B6129PF2/J. It also depicts the time-dependent behavior of the vein graft intimal thickening. Morbidly obese woman unaware of pregnancy until full-term and complicated by intraamniotic sepsis with pseudomonas. Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Sustained hemodynamic effects of the selective dopamine-1 agonist, fenoldopam, during 48-hour infusions in hypertensive patients: a dose-tolerability study. Slow metabolizer status and gene variants in KCNH2 associated with increased expression of Kv11.1-3.1, an alternatively spliced isoform of Kv11.1, are correlated with improved responses to antipsychotic medications. Diffusion tensor imaging tractography of the fornix and belief confidence in first-episode psychosis. Clinical clues for endocarditis in this cohort are minimal and diagnosis may be delayed.

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Intent to stay in the job mean scores increased, and the registered nurse participants reported program satisfaction through verbal and written feedback. Sodium administration to this cohort of critically ill patients requiring prolonged mechanical ventilation was high. Two efficient algorithms termed common orthogonal basis extraction (COBE) are proposed to extract common basis is shared by all data, independent on whether the number of common components is known beforehand. Congenital esophageal stenosis (CES) is rare and usually manifests in infants as dysphagia, failure to thrive, and food impaction. This paper highlights the molecular essence of graphene and presents its hydrogenation from the viewpoint of the odd-electron molecular theory. Comparison of glucose homeostasis parameters between patients with high and low risk of diabetes at 6 weeks and 6 months after sleeve gastrectomy. The use of calorimetry to characterize small molecule-RNA interactions has emerged as a reliable and sensitive tool after the recent advancements in biocalorimetry. By immunohistochemical staining with a monoclonal antibody (MAb60B8) directed against MRP-14, we tried to correlate features of expression of MRP-14 protein in phagocytes with particular histopathologic stages of granuloma. While not attempting to be exhaustive, this review attempts to provide an overview with additional in-depth information on certain classes of drugs that are either of general importance or have recently emerged in the literature. Conservative management consists of bowel rest, antibiotics, wound care, and the administration of drugs that either reduce gastrointestinal motility or secretions.

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Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study. The simulated results had agreement with the experimental results that the measurement accuracy of both strain and temperature were improved by increasing the birefringence. No significant effect of clonidine was observed in the 21-day-old rats. Tissue from 30 cases formed part of a retrospective survey while a further 7 cases were obtained prospectively. The analysis of selected maternal morbidity and mortality data prospective collected in the years 2007-2012 from all obstetrics hospitals in the Slovak singulair cost Republic. Adaptation studies seek a graded recovery from neural adaptation with ever greater dissimilarity between pairs of stimuli.

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Ln-MOF inks were used to reproduce color images that can only be observed under UV light irradiation. This study aimed to clarify whether the focus of attention influences not only motor performance but also activity of the primary motor cortex (M1) when executing identical fatiguing tasks of the right index finger (first dorsal interosseous). Therefore, artificially controlling the interface SBH is of great importance for their industrial applications. Cystic nephroma is a rare benign cystic renal tumor, which has been only recently recognized as an exclusively adult histological entity. Subsequent sequence analysis revealed that, on the basis of the about 410-bp sequence information, all four primers amplified similar, as well as different (including novel), bacterial groups from soil. From SCFT simulations of the model, two phase diagrams corresponding to temperature independent or dependent interaction parameters chi are constructed, which qualitatively capture the phase behavior of the monoolein-water mixture. Pressure ulcers in community-based older adults receiving home health care. The Recovery Knowledge Inventory for Measurement of Nursing Student Views on Recovery-oriented Mental Health Services.

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The bandwidth shortage has motivated the exploration of the millimeter wave (mmWave) frequency spectrum for future communication networks. Intercomparison of three recruitment maneuvers in acute respiratory distress syndrome: the tenormin 50 mg price in uae role of Body Mass Index. The nuclear factor-kappaB (NF-kappaB) transcription factors play important roles in cancer development by preventing apoptosis and facilitating the tumor cell growth. In an effort to localize the antiestrotrophic portion of the molecule, the C-terminal one-third (200 amino acids) of human AFP, known as Domain III, was produced in a baculovirus expression system as a fusion protein containing an amino terminal histidine tag. The aim of this study was to provide reference values for coagulation studies within the first 24h of life, and to relate these findings to the incidence of IVH.

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This review summarizes the current knowledge on multimerin 1 including its orthologous genes, restricted pattern of expression, structure, biosynthesis and functions. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. The thromboelastography xanax dosage form profile of each subgroup was characterized and group features were compared. To cast light on this question regarding use of open as compared to laparoscopic radical prostatectomy (LRP) the present study was conducted focusing on biochemical (PSA) recurrence-free survival of Japanese patients with clinically localized prostate carcinomas. The relationship between the orientation of the early chick embryo and the shape of the egg shell.

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Long-term visual acuity outcomes in patients with uveal melanoma treated with 125I episcleral OSU-Nag plaque brachytherapy. Patient stakeholders should be involved in this process to ensure their concerns and preferences are considered. The activities of developmentally critical transcription factors are regulated via interactions with cofactors. Re: Weld KJ, Koziol S, Montiglio C, et al: Feasibility prometrium 200 mg benefits of laparoscopic renal cooling with near-freezing saline irrigation delivered with a standard irrigator aspirator. Our data therefore suggest a functional role of Y RNAs in a common pathway with ORC. To investigate whether the occurrence or clearance of microhemorrhages in cerebral amyloid angiopathy (CAA)-related vascular inflammation can be modified by immunosuppressive treatment. Ribonucleotide Reductase (RNR) is an important anticancer chemotherapy target.

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cAMP analogue 8-CPT-cAMP inducing differentiation in the M2b subtype of acute myeloid leukemia cell line Kasumi-1. Prevalence and correlates of depression and anxiety disorder in a sample of inmates in a Nigerian prison. Our findings show that perceived stress from disease, coping styles, social support are the independent determinants of anxiety and depressive symptoms among Chinese patients with type 2 diabetes. The research was carried out in specific areas of the Yaounde urban center where most of these delinquent children have their meeting points. MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. amazonensis-induced macrophage apoptosis was associated to activation of caspases-3, -8 and -9 in both strains of mice. Early and late components of visual categorization: an event-related potential study. Epigenetic Mechanisms: An Emerging Player in Plant-Microbe Interactions. This secondary-data analysis examined rates of homelessness and their relation to the therapeutic workplace intervention and alcohol use during the trial.

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Biosimilars for psoriasis: preclinical analytical assessment to determine similarity. Changes of lung tumour volume on CT - prediction of the reliability of assessments. Soil can be a storage place and source of pollutants for interfacial environments. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Taken together, the results of this study show that real-time PCR assays targeted to the large subunit of mtDNA may become useful tools for the study of coexisting AM fungi. Our results suggest that bioreducible DOX-loaded mPEG-(ss-TPP)2 NPs can induce fast drug release with enhanced mitochondrial uptake and have a better therapeutic effect than nonbioreducible NPs. Inverse correlation between the vascular endothelium growth factor plasma concentration, desquamated endotheliocytes number in peripheral blood and bilirubin level was detected, that points to the protective role of bilirubin in the prevention of the endothelium dysfunction development. The purified antigens were covalently bound to fluorescent beads and then assayed with 822 characterized ruminant sera from BTV vaccinations or infections in a duplex microsphere immunoassay (MIA). This review summarizes the current state of the field in the diagnosis of FTLD and discusses the emerging role of neuropsychology in elucidating the brain organization of complex processes including empathy, behavioral control and inhibition, reward systems, appetitive behaviors, emotional regulation, and goal-orientation. The prospect of long-term residence in outer space is becoming a reality.

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hsTnI may have a role in personalizing preventive strategies in patients with diabetes mellitus based on risk. Smoking family predicts adolescent smoking, but whether the level of nicotine addiction is affected by exposure to secondhand smoke (SHS) is unclear. The organization and financing of health care: implications for medical school-teaching hospital agreements--Part 3. Outcome variables were high sensitivity C-reactive protein (hsCRP), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglyceride concentrations measured at follow-up (2012-2013). Changes in core temperature compartment size on induction of general anaesthesia. On being taken up by the cells, 2,5-AM was converted into its monophosphate and diphosphate by the enzymes of the glycolytic pathway. Thus, GKRS is a valuable adjuvant to transsphenoidal microsurgery for patients with pituitary microadenomas. Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection.

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