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Acupain (Tramadol)

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Acupain is an oral medication that is used to help relieve ongoing moderate to moderately severe pain. Acupain is similar to opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Other names for this medication:
Acema, Acupain, Adamon, Armadol, Cadol, Damadol, Dolomed, Dolriz, Euphodol, Ibudol, Inodol, Kamadol, Madol, Mandol, Medol, Mobiya, Mydol, Neutram, Nosdol, Ondol, Orchidol, Painadol, Pentazen, Postadol, Ramax, Ramcet, Redimol, Rybix, Soztram, Tandam, Taramol, Tragesic, Tramacip, Tramacon, Tramak, Tramalex, Trampar, Trandy, Trazac, Ultraspas, Urogendo, Vardol

Similar Products:
Estrace, Zebeta, Protonix, Pepcid, Urispas, Vasotec, Celexa, Cenforce, Amaryl, Dilantin

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Acupain if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Acupain should not be given to a child younger than 12 years old. Acupain ER should not be given to anyone younger than 18 years old.

Do not give Acupain to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Acupain. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Acupain is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Persistent infections in the children presenting with chronic ENT diseases: the potential of etiotropic therapy. An ultrasonic multi-beam concentration sensor was considered to solve these problems, but an abnormal concentration value of a specific ultrasonic beam degrades the accuracy of the entire measurement in case of using a conventional arithmetic mean for all measurement values, so this paper proposes a method to improve the accuracy of the sludge concentration determination by choosing reliable sensor values and applying a neuro-fuzzy learning algorithm. While the prepulse inhibition effect reflects an inherent early attentional gating mechanism, the partial reinforcement extinction effect is believed to involve the development of acquired inattention, i.e. While households may adopt diverse coping mechanisms, the stage in the household life cycle when stressful events occur is important for coping outcomes. Efferent contacts on IHCs contained focal presynaptic accumulations of small vesicles. Treatment with soluble fiber (Metamucil) added to a highly digestible diet (Hills i/d) resulted in a very good to excellent response in most dogs. Intrastrain variations in CRP sequences revealed the existence of several copies per strain. Changes in the body weight and total body water of differently aged rats during a 5-hr.

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To determine the level of agreement between dynamic ultrasound imaging and stress radiography used for the measurement of inferior glenohumeral laxity in asymptomatic shoulders, and to determine the repeatability of the dynamic ultrasound technique. However, the sensitivity of vitamin D(3) receptor-retinoid X receptor heterodimers to 1alpha,25(OH)(2)D(3) was found to be much higher than to retinoid X receptor ligands. Integrated backlight module to provide a collimated and uniform planar light source. Then, the formula was subjected to internal validation using the validation set using receiver operating characteristic (ROC) curves. Patients with progressive vision loss due to MF who were treated with vitrectomy with ILM peeling show favourable outcomes.

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BLAST analysis revealed that the identified cDNA encodes a KDWK domain and contains sequences almost identical to three tryptic peptides of rat GMEB-1 which together with the GMEB-2 heterodimeric partner binds to the GME/CRE sequence (glucocorticoid modulatory element) of the tyrosine aminotransferase (TAT) promoter. Health perceptions can be improved through both psychosocial support and specific intervention programs. Increasing evidence suggests that there may be a causal relationship between the development of donor-specific alloantibodies and chronic allograft vasculopathy (CAV). To present the results of ureteroplasty and technical features of ureteric replacement using the Yang-Monti procedure. We discuss the design and realization of such wave plates and demonstrate our technique with polarization measurements of both polarized and partially polarized CO(2)-laser radiation at a wavelength of 10.6 mum. Examples are presented from the filtered XRD arrays, named Dante, at the National Ignition Facility and the Laboratory for Laser Energetics.

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Legalization of cannabis: between political irresponsibility and loss of responsibility of psychiatrists. Gold nanorods (AuNRs) that contained polyvinyl alcohol/chitosan (PVA/CS) hybrid nanofibers with dual functions are successfully fabricated by a simple electrospinning method. Some patients develop severe brain edema after complete middle cerebral artery occlusion, whereas others do not. In contrast, post-endocytic gp135 is delivered to the AEE before recycling back to the apical membrane. The ldhL gene from Lactobacillus plantarum was introduced into L. These results suggest a novel TRAIL-mediated pathway for elimination of Cryptosporidium infection and a role for OPG in modulating this host response. Molecular Seesaw: Intricate Dynamics and Versatile Chemistry of Heteroaromatics on Metal Surfaces.

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Trajectories of maternal mental health: a prospective study of mothers of infants with congenital heart defects from pregnancy to 36 months postpartum. Endoscopic therapy arrested active bleeding without any complications in all cases without the need for further surgery or endoscopic treatments. Development of an electronic device to organize medications and promote treatment adherence. A clinical-electroencephalographic study on photosensitive epilepsy, with special reference to visual evoked potential. Results suggest that the SOCS multi-gene family derived from the expansion of an ancestral SOCS gene through at least cubical duplication events during evolution process. Modern cities depend on individualism and the process of contracting. These results indicate that peripherin/Rds and Rom-1 associate noncovalently to form multisubunit core complexes. These codendrimers were found to self-assemble into ribbonlike aggregates in organic solvent and further formed three-dimensional networks and behaved macroscopically as gels. Identification of proteins associated with LMP2A is important for elucidation of the mechanism that LMP2A employs to regulate B-cell signal transduction and EBV latency. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy.

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Trial of acidified milk for premature infants (clinical and biologic surveillance). Recent advances in biology and materials science have pushed tissue engineering to the forefront of new cartilage repair techniques. Here, we present a comprehensive transcriptome dataset for future genomic studies into this species. Dietary intake (24-h recall), and serum levels of folate, vitamin B12 and ferritin were estimated. pastoris strain capable of producing humanized N-glycosylated proteins was constructed.

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In this multicenter study, institutionalized patients have a high prevalence of at risk of malnutrition assessed by MNA-SF test. Descriptive analyses were performed, and the Cox proportional hazard flagyl dosing appendicitis model was applied to assess if NR2-ab level is an independent predictive factor of survival. Topic: Abdominal Wall Hernia - Spigelian hernia, anatomy, incidence, repair. After a median follow-up of 14.3 years, 787 incident gastric cancers were documented. A chronic care model significantly decreases costs and healthcare utilisation in patients with inflammatory bowel disease. Because IkappaBbeta has been implicated in maintaining NF-kappaB.DNA binding, we sought to investigate whether IkappaBbeta was involved in maintaining persistent NF-kappaB activation in HIV-1-infected monocytic cell lines. Cox proportional hazards modeling was used to identify factors associated with LOS. However, it remains to be fully established what types of error the SAC respond to, for example the presence of univalents, and how sensitive it is to attachment or tension defects in bivalent alignment.

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There is a conflicting evidence of the effect of milk addition to tea on antioxidant activity. Contrary to the negative correlation in the MAOS regime, the colloidal gel shows an oscillating dynamics with a positive correlation between the absolute value of strain and the average bond number. Carotid arterial ultrasound scan imaging: A direct approach to stenosis measurement. It gives the possibility that the object be seen, localized, sampled and evacuated entirely. An autopsy case of amyotrophic lateral sclerosis/parkinsonism-dementia complex with family history and living history in the Kii Peninsula focus.

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Two surgeries were performed at different times and neither of them presented any morbidity. Here, high-pressure liquid chromatography analyses of culture medium were used to show that the major products of aerobic 1,2-PD degradation are propionaldehyde, propionate, and 1-propanol. Applicable far beyond the pairwise-additive small-strain regime, the models may be used to describe microelasticity of nanocolloids in severe confinement including dense disordered and crystalline phases. Several PET tracers are under investigation because of the low performance of the FDG in prostate cancer. GORouter is licensed under Apache License Version 2.0, and is accessible via the website: In order to understand the mechanism of stress-induced hippocampal Zn dyshomeostasis can you drink alcohol after taking claritin d , relative quantitative analyses of metallothionein (MT), B-cell lymphoma 2 (Bcl-2) and caspase 3 immunoreactivity were performed.

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The role of image-guided therapy in the management of colorectal cancer metastatic disease. Temporary placement of covered self-expandable metal stents in benign biliary strictures: a new paradigm?. Functional networks involved in spatial learning strategies in middle-aged rats. External oblique aponeurosis nerve entrapment as a cause of groin pain in the athlete. Benign acanthosis nigricans with atonic cerebral palsy, mental retardation and convulsions.

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Because it is difficult to experimentally manipulate body size of organisms, most studies of metabolic scaling depend on correlative data, limiting their ability to determine causation. Three of them were identified as different polymorphic forms of proline-rich proteins (PRPS) and the other as alpha-amylase. Statistical association analyses were tested between these values and AD apathy and severity scores. Cyclic voltammetry at micropipet electrodes is applied to the kinetic study of ion transfer at liquid/liquid interfaces. Parallel incubation rebetol capsule uses in hindi of a large number of samples with a small library of peptides is enabled by printing multiple identical mini-arrays on one microarray slide and further combining four slides to yield an incubation frame possessing the dimensions of a 96-well microtiter plate. Saraines 1-3 and isosaraines 1-3 are characterized by a trans-2-oxoquinolizidine moiety bound directly to a tetrahydropyridine ring, both nuclei being also linked by two alkyl chains of different lengths.

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Adaptation of an Aedes aegypti cell line to hemolymph-free culture medium. Transcriptional activity of the heme oxygenase-1 gene (HMOX-1) is modulated by a GTn-repeat promoter polymorphism. The hydrogel emulsions were physically cross-linked by freeze-thaw cycling. The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. We did not detect any significant differences in the apo(a) phenotype frequencies between the two groups. This November sees a major conference for students of mental handicap nursing. The aim of this study was to investigate its beneficial effects beyond angiotensin-converting enzyme (ACE) inhibition using angiotensin II-infused rats as hypertension model. Those not covered immediately by the policy serve as controls and they should be randomly allocated is xanax a schedule ii drug .

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In contrast, researchers using functional magnetic resonance imaging and multivoxel pattern analysis methods have recently documented direction-specific responses within many regions of the visual system (e.g., visual cortical areas V1-V4v) not normally associated with motion processing. Recently, the investigation of the genome sequencing was finished and this data potentially clarifies the biochemical characteristics of B. Interaction energy evaluation of soluble microbial products (SMP) on different membrane surfaces: role of the reconstructed membrane topology. In addition, the differential diagnosis of intraoperative arterial hypotension is described. During the operation cystic duct and vessels are usually controlled by Hem-o-lok clips. The case and control groups showed no significant differences in the major risk factors except for waist-to-hip ratio (WHR) which was higher in the IFG with NGT. Both the topological properties and the identity of the key groups differ. Because of worse prognosis of metastatic cancer and any ocular complications, the patient was treated by radiotherapy which allowed a clinical improvement. Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts. Ultrasound can be a reliable alternative to plain radiographs, thereby avoiding radiation exposure and its potential detrimental sequelae in the developing child.

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This issue has been appreciated in liver and kidney tissue, but has received very little attention in nervous tissue. To compare balance, mobility, recent falls, and injuries among elderly African American and white women. CgMTL3 contains an identical copy of the Cgalpha1 gene but a longer variant of the Cgalpha2 gene that we termed Cgalpha3. Glucocorticoids can induce mitotic synchrony that in turn suppresses the pro-inflammatory state of diseased cells, suggesting a novel anti-inflammatory mechanism of action. A novel random forests-based feature selection method for microarray expression data analysis. Significance of aspiration biopsy of the stomach for the diagnosis of postresection gastritis. Multicenter study of serous cystic neoplasm of the Japan pancreas society. Use of intravoxel incoherent motion diffusion-weighted imaging in identifying the vascular and avascular zones of human meniscus.

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Using whole-exome sequencing of case-parents trios, we have identified a de novo missense mutation in TRPV3 that produces p.Gly573Ser in an individual with OS. The effects of ECT on cognitive functioning in the elderly: a review. We define 9 bitter compounds which elicit aversive behavior in a dose-dependent manner. The required refraction measurements and the algorithm utilized to recover density protonix 40 mg oral tablet delayed release and temperature are described. Cardiopulmonary effects of the laparoscopic pneumoperitoneum in a porcine model of adult respiratory distress syndrome. Association of interleukin-6 single nucleotide polymorphisms with juvenile idiopathic arthritis.

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Short electrocardiography records were taken in the supine position and during orthostatic tests. Analysis of domoic acid in shellfish by thin-layer chromatography. We used a questionnaire and nurse observation forms to assess the use of the open and closed system suctioning. The peptide structures of the 13 degradation products were deduced from the sequence analysis and the molecular mass. This study aimed to assess confidence level of healthcare professionals in venipuncture and their knowledge on the possible causes of in vitro hemolysis. Favorable Response of Metastatic Merkel Cell Carcinoma to Targeted 177Lu-DOTATATE Therapy: Will PRRT Evolve to Become an Important Approach in Receptor-Positive Cases?. In this work, we explore the relationship between disease prevalence and other factors and the size of interventional phase 2 and 3 rare disease trials conducted in the US and/or EU. Ninety-five fourth year and 62 final year students along with 67 physicians working in medical departments participated in the survey.

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The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced L-arginine transport and impaired nitric oxide bioavailability in advanced disease. Prostatic stromal cells may be critically involved in growth and progression of prostate cancer. Bone morphology and moprhometric estimation provide important and useful information for computed assisted-surgery, follow-up evaluation and personalized prosthesis design. Semi structured interviews about the receipt of the intervention were conducted with the nurses and log files were kept regarding the consultations. The first-stage applies an input oriented variable returns to scale DEA analysis. The calculated dose of radiation received by the dissected area in those with healed versus non-healed dissection was also compared.

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