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Adgraze (Adapalene)

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Adgraze is a retinoid. While experts aren't exactly sure how it treats acne, they believe it works by stopping pimples from forming under the skin and lowering the amount of redness and inflammation on the skin.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Revia, Cialis, Trileptal, Avapro, Hydrea, Suprax, Dulcolax, Zantac

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Adgraze and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adgraze are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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We describe here a 45-year-old male who presented with pain in the abdomen and a lump in the left iliac fossa for two months. Two mouse monoclonal antibodies against the human complement control protein, Factor H (beta 1H), are described. Treatment with DE gamma E injected into the accumbens for 4 days resulted in an enhancement of apomorphine-induced hypoactivity. Antibodies specific for rubella virion polypeptide, VPI, secreted by clones of hybridoma cells or produced in rabbits in response to specific antigenic stimulation, located determinants for haemagglutination inhibiting (HI) and neutralising (Nt) antibodies on this envelope component. Data supporting or negating one hypothesis or the other were elicited from the literature. We quantified community-based ambulatory activity profiles in terms of step counts and intensity, along with cardiovascular fitness and fatigue severity, in a convenience sample of 79 men and women with chronic hemiparetic stroke. Upon this diagnosis, the thyroid gland was re-evaluated by ultrasound, which demonstrated a solitary, hypoechoic nodule in the right lobe. Gallic Acid Decreases Inflammatory Cytokine Secretion Through Histone Acetyltransferase/Histone Deacetylase Regulation in High Glucose-Induced Human Monocytes.

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Randomised and quasi-randomised controlled trials that assessed the effect of anticoagulant treatment on the live-birth rate in women with a history of at least two miscarriages (up to 20 weeks of amenorrhoea) without apparent causes other than inherited thrombophilia were eligible. Shortage of safe blood donors is frequent and it is important to understand the causes of deferral of potential donors, who reside mainly in urban areas, to improve recruitment campaigns aiming at the quality/availability of donors. Western immunoblot analysis indicates that neoplastic B cells secrete 60- as well as 14-Kd protein. No statistically significant differences in permeability could be demonstrated for both mucosae toward sumatriptan. The most objective choice of the patients as well as a correct conceived and executed therapeutical plan, the follow-up cooperation with the patient, in what concerns the strict oral hygiene, would had to an increasing number of successfully solved cases. The mean values --from 1985 to 1994-- of the following indicators were obtained for each province: mortality index (deaths/accidents), harmfulness rate (victims/accidents), fatality rate (deaths/victims), motorization index (vehicles/inhabitants) and population density. Additionally, three-dimensional (3D) single-layer RPE maps done in 111 healthy volunteers served as control. Nevertheless, the delayed increase in cAMP levels following FMRFamide treatment may suggest that cAMP is not mediating the onset of FMRFamide cardioinhibition.

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The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism of Syrian hamster Harderian glands were studied. In public and private hospitals, off-site transportation of the hospital waste is undertaken by Municipal Assemblies with the use of trucks. We discuss key aspects of sample preparation, column, and solvent selection for off- and online extractions, and the so-called nuts-and-bolts of online column-switching systems necessary for developing-with minimal sample handling-rugged, automated methods. Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans. The risk of emergent bradycardia associated with metoprolol initiation was higher with the IR formulation than the SR formulation, although the absolute risk was low. Further research is needed to support retention of DR-TB patients on treatment, even within community based treatment programs.

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One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Contamination of water objects with helminth eggs and protozoan cysts in the Minsk Region. We reviewed the literature concerning markers used to differentiate between GBM and SCLC and found that most of these markers showed limited specificity. Determination of head position and mandible growth direction can be an important indicator in patients with TMD treatment. She was treated with resection of the coccyx, and symptoms disappeared after surgery. Aspirin treatment before and after primary angioplasty appears to improve the remote prognosis following PTCA as compared with the patients having received no aspirin. WHAT DOES THIS STUDY ADD?: This study brings the evidence that N2 O reduces the remifentanil aggravated secondary hyperalgesia in human volunteers exposed to a well-known model of electrical pain. This occurs without altering hemodynamic variables in a clinically significant manner. In 20 studied patients with H.pylori-associated chronic gastritis composition of local microflora was less diverse--conditionally pathogenic, lacto- and bifidobacteria often were absent. Epidermal growth factor receptor (EGFR) mutations are prerequisites for the targeted therapy with anti-EGFR tyrosine kinase inhibitors (TKIs) in non-small-cell lung carcinomas (NSCLCs).

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After 3 weeks on the diets the animals were injected with a single dose of MBN (2.0 mg/kg b.w.) and levels of esophageal O6-MeG were determined after 1, 3, 6 and 24 h. Biodegradation of soil-applied polycyclic aromatic hydrocarbons by sulfate-reducing bacterial consortium. A post hoc analysis of saxagliptin efficacy and safety in patients with type 2 diabetes stratified by UKPDS 10-year cardiovascular risk score. Mechanisms of orbital blowout fracture: a critical review of the literature. Both sonography and technetium Tc 99m sestamibi single-photon emission computed tomography (SPECT) are commonly performed during imaging evaluation of patients with primary hyperparathyroidism (HPTH). Interestingly, this effect is associated with a marked accumulation of poly(A) mRNAs in cell nuclei. Even in these RNase-less strains, guanylic-acid rich oligonucleotides, polyG or trypan blue effectively induced SLS production, as in RNase-positive cells. This study retrospectively reviewed 9 patients who underwent occipitocervical fixation with a newly developed screw-rod fixation system between April 2004 and November 2005.

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Parental psychopathology in child and adolescent obsessive-compulsive disorder. Intermittent bisphosphonate therapy in postmenopausal osteoporosis: progress to date. DETECT raises the hypothesis that dalteparin 5,000 units SC daily may not be clinically noninferior to enoxaparin 30 mg SC twice daily for VTE prophylaxis in this high-risk population. Plasma pro-endothelin-1 peptide concentrations rise in chronic kidney disease and following selective endothelin A receptor antagonism. Furthermore, synaptic activity induced a pronounced increase of the glial coverage of both pre- and postsynaptic structures, these changes being prevented by application of the NMDA receptor antagonist D-2-amino-5-phosphonopentanoic acid. She underwent a 3rd operation to remove the Co and Cr alloy prosthesis of her right knee in February 2005, and suppuration improved 2 months later. The purpose of this paper is to outline and discuss some of the fundamental theoretical and practical considerations bearing on the teaching of communications skills to nurses. There is a paucity of data regarding the treatment of endocarditis caused by penicillin-resistant viridans group streptococci (PR-VGS).

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In a prospective, observational trial cuff pressure was recorded in paediatric and adolescent patients intubated with a cuffed tracheal tube during sevoflurane/nitrous oxide anaesthesia. Impact of tuberculosis preventive therapy on tuberculosis and mortality in HIV-infected children. The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3. Proactive community centred intervention programmes using multiple approaches were found to be successful to increase the participation rate for intervention. Radiographically it presented as a cystic lesion of the whole of the metatarsal. Throughout history, physicians of the armed forces have gained experience in tropical medicine during deployment in tropical countries.

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Activity in language networks was measured with O-15-water positron emission tomography during verb generation before and after treatment. We consider that the morphological and functional study of the thymus biopsy specimen should supply the appropriate criteria of suitability for surgical treatment. The low temperature mean free path is determined by impurity scattering, while at high temperature, the mean free path decreases with increasing temperature, indicating that it is limited by electron-phonon scattering. C1-C2 fusion is an option for Down syndrome patients younger than 5 years with atlantoaxial dislocation, when the dislocation is reducible. Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles. We present a molecular dynamics simulation study in which we compare and contrast the performance of a polarizable shell water potential model and non-polarizable water force field-extended simple point charge (SPC/EF) model in predicting the solvation dynamics of confined water molecules sandwiched between MgO(100) slabs. aeruginosa (strain 4020) and identified mutants resistant to nonopsonic phagocytosis. We correlated Cryptochrome-1 mRNA with well established prognostic markers such as IgV(H) mutations, ZAP70, LPL or CD38 expression and chromosomal abnormalities. Diffuse (disseminated) cutaneous leishmaniasis and HIV co-infection is emerging as an extremely serious new disease. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.

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Is specific antibody determination diagnostic for asthma attributable to low-molecular-weight agents?. Preclinical testing and optimization of a novel fetal micropacemaker. To assess the efficacy and safety of cross-linking in pediatric patients with keratoconus and to provide a systematic literature overview regarding this subject. The evaluations of expectancies did account for a significant portion of the variance but appeared secondary to the general attitude measure. We have developed a new format for teaching materials that enhance teacher-student and teacher-teacher interactions, reduces redundant content and integrates disciplines through patient-oriented medical education. Evidence for conformational changes leading to alterations in antigenicity. She initially presented with edema and proteinuria at a pregnancy check-up. Taken together, these results may help us better understand trophic interactions. Although several innovative tissues have been proposed for possible use as free grafts for urethral repair, all have specific advantages and disadvantages.

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Development and application of a capillary electrophoresis based method for the simultaneous screening of six antibiotics in spiked milk samples. The present study investigated the prevalence and severity of menopause symptoms experienced by Korean women aged 44 to 56 years and their associated factors. Forty-seven patients with histologically confirmed NASH and 41 healthy controls were included in the study. The burden of CKD to a family in a developing country is enormous, and if more than one child is afflicted with the condition, the situation is almost catastrophic. The diagnosis depends on examination of a vertebral biopsy specimen.

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Two of the serotypes did not share antigenic relationship with strain S1133, which has been used in the field to vaccinate chickens against viral arthritis. Repeated pulses of serotonin (5-HT) induce long-term facilitation (LTF) of the synapses between sensory and motor neurons of the gill-withdrawal reflex in Aplysia. Results showed that some degree of hearing preservation was possible in 15718 patients. Diabetes and diabetic bladder disfunction will have a great impact on quality of life due to an aging population. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. Our Pep-3D-Search provides a powerful approach for localizing the surface region mimicked by the mimotopes.

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Surgical removal of peripapillary choroidal neovascularization in young patients. Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are among the leading causes of respiratory tract infections requiring admission to the pediatric intensive care unit (PICU). The large late virus transcripts synthesized in herpesvirus suis (pseudorabies) virus-infected cells are not precursors of mRNA. The differential staining technique has advantages over conventional backfilling techniques for examining the morphological relationships of populations of neurons having different axon projections. The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different flagyl and alcohol reaction name subtypes of breast cancers. NQ304 potently inhibited adenosine diphosphate (ADP), collagen, epinephrine and calcium ionophore-induced human platelet aggregation in vitro dose-dependently.

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