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Alprazolam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Alprazolam is mostly used to treat anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprazolam may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. The FDA label advises that the physician should periodically reassess the usefulness of the drug.

Other names for this medication:
Alfresh, Alpranex, Alprocalm, Alpronit, Alrif, Alzopam, Alzoset, Alzotime, Anxit, Anzocalm, Axizox, Calmtec, Diprex, Dizeral, Fluti, Himzolam, Isorest, Mentolift, Notens, Parazolam, Pronil, Resolin, Resto, Rezolam, Zocam

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Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alprazolam. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprazolam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprazolam dosage information

Side effects

The most common side effects associated with Alprazolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alprazolam if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Alprazolam is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Alprazolam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Alprazolam is not approved for use by anyone younger than 18 years old.

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The development, regulation, and mechanism of the kidney clock are reviewed here. Here, we revisit studies on TCM ZHENGs using this approach, highlight its applications on elucidating the potential scientific basis of ZHENG and investigating mechanisms of action for the TCM formula, and demonstrating its unique role in novel TCM drug design and discovery through active ingredient detection from TCM and compatibility theory study of TCM. We isolated a NAM, ATAF1/2, and CUC (NAC) domain-containing transcription factor, PtrNAC72, from trifoliate orange (Poncirus trifoliata) by yeast one-hybrid screening. A total of 369 and 334 nasopharyngeal, or nasal/throat swab samples, collected during the 2012/2013 and 2013/2014 seasons, respectively, were tested using specific singleplex influenza A, influenza B, influenza B/Yamagata and influenza B/Victoria real-time reverse transcription polymerase chain reaction (RT-PCR) assays. The medical records of 200 consecutive patients who had feeding tubes inserted with assistance from an electromagnetic feeding tube placement device were reviewed retrospectively.

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DBPs are molecular motor proteins that utilize chemical energy in cycles of ATP binding, hydrolysis, and product release to perform mechanical work resulting in reorganization of cellular RNAs. An enamel adhesion study of Esterfill adhesives with chemical and light hardening. In fact, many inhibitors of Akt pathway have been identified and clinical studies of some agents are ongoing. A main research in this area is represented by the inference of biological networks from experimental data. Nevertheless, after 7 years form the surgical excision, she developed a recurrence of the lesion on the same site. A compact process for treating oilfield wastewater by combining hydrolysis acidification, moving bed biofilm, ozonation and biologically activated carbon techniques.

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Nickel, copper, and zinc centered ruthenium-substituted porphyrins: effect of transition metals on photoinduced DNA cleavage and photoinduced melanoma cell toxicity. Humans use internal models to estimate gravity and linear acceleration. In vitro, apoptotic blebs can induce maturation of dendritic cells (DC), which in turn can stimulate IL-17 production by T cells. We used detailed image processing to compare signal change before and for 30 minutes postcontrast throughout gray matter, white matter, and cerebrospinal fluid with summary analyses and general linear modeling. OCT can identify different patterns of RNFL involvement specific to different classic VF defects in eyes with NAION. Detection of an elevated HER2 expression in MCF-7 breast cancer cells overexpressing estrogen receptor beta1. The qualitative assessment demonstrated that the CARDIFF, Sheffield T2DM and ECHO T2DM models seem technically equipped to appropriately assess the long-term health-economic consequences of chronic treatments for patients with T2DM.

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When a referent is previously given and assigned topic status, it is even more likely to be produced early in a sentence, but not in a word list. To our knowledge, this is the first report of molecular evidence of B henselae infection in a dog with peliosis hepatis. A systemic transcriptome analysis of the cyanobacterium Synechocystis sp. The objective of this study was to determine the interaction of modified bilayer lipid membranes (BLMs) with lead and tin organoderivatives. Given that expectant and new mothers regularly come into contact with staff and providers in primary care, sound knowledge and positive attitudes toward breastfeeding appear to have had a favorable effect on mothers that correlates with improved breastfeeding duration. These effects differed somewhat when levels of global, non-specific distress were controlled. Fluorosis was scored on these children using the Tooth Surface Index of Fluorosis (TSIF).

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This article aims to observe the phasic changes in cell proliferation in an autogenous vein graft used to repair the lacrimal canaliculus. The young boy did a treadmill stress test which was positive for myocardial ischemia. Sustained release of PTH(1-34) from PLGA microspheres suppresses osteoarthritis progression in rats. Cell survival upon Fluorouracil treatment was analyzed in a CCK assay. Selective serotonin reuptake inhibitors and pregnancy: A review of maternal, fetal and neonatal risks and benefits. However, even small decreases in kidney function are associated with a worsened outcome. Efficient Fludarabine-Activating PNP From Archaea as a Guidance for Redesign the Active Site of E.

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The loss of other gene products (RsbR and Obg) known to participate in the stress activation pathway had little influence in blocking the ethanol effect. The results are evidence that dietary boron deprivation in mice alters periodontal alveolar bone modelling and remodelling by inhibiting bone formation. A novel thermosensitive P(NIPAAm-co-HPM)-g-TMSPM-g-microcarrier was prepared here as a three-dimensional (3D) culture substitute. Patients with severe croup maintain minute ventilation by means of huge increases in intrathoracic pressure changes. Aspergilloma is the most common form and can be difficult to distinguish from chronic necrotising aspergillosis. The framework recommended by the Medical Research Council of the United Kingdom for the development and evaluation of complex health interventions was used to conceptualise the intervention. A specific beta-glucosidase-aggregating factor is responsible for the beta-glucosidase null phenotype in maize. In contrast, BRCA1 is dispensable for repair of restriction endonuclease-generated double-strand breaks. A randomized sham-controlled double-blinded trial was performed as a pilot study. High content protein interaction screens have revolutionized our understanding of protein complex assembly.

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The oncologist is the first and most important contact for the patient and, hence, should bring up the issue of family planning and fertility. B-cell CLL is characterized by progressive defects in both cell-mediated and humoral-mediated immunity. A DNA Aptasensor for Electrochemical Detection of Vascular Endothelial Growth Factor. The differences between these 2 groups were examined using the chi-square test and the t test. Systematic review registration PROSPERO CRD42015017564 ( The method can be further developed and applied to other threshold problems in functional electric stimulation and pacing. We wanted to study the effects of biweekly dog visits on sleep patterns and the psychiatric well-being of elderly people. Analysis of the acupuncture needle stimulation scan showed that compared with sham treatment, verum acupuncture activated the left operculum/insula, which also overlaps with findings observed in resting state analysis.

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Cauda equina syndrome (CES) is a rare complication after NA but can result in severe neurologic deterioration that may require surgical intervention. Here, we aimed to explore the effect of SGI-1776 on salivary adenoid cystic carcinoma (SACC). The FDG-PET/CT scan results, SLN plus frozen section results and definitive pathology results of the inguinal lymph nodes were compared. Preventive immunisation could reduce the risk of meningococcal epidemics in the African meningitis belt. All patients aged 20-60 years attending the practices who had received a NHS-funded root filling in a mandibular first permanent molar between January 1998 and December 2003. Bacteria are able to attach to the surface of indwelling medical devices and cover these surfaces with biofilm. Involvement of cyclic AMP - PKA pathway in VIP-induced, charybdotoxin-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats. Our results indicate that HS induces resistance to potentially lethal and mutagenic effects of BLM. Bats (Order Chiroptera) are an abundant group of mammals with tremendous ecological value as insectivores and plant dispersers, but their role as reservoirs of zoonotic diseases has received more attention in the last decade. Although pterygium surgery significantly reduces refractive astigmatism and topographic irregularity, spherical power increases and the cornea becomes steeper.

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Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. Poster 171 An Unusual Case of Foot Drop Secondary to Compartment Syndrome: A Case Report. Results indicated that ATO and rmhTRAIL had synergistic or additive effects on proliferation inhibition and apoptosis induction in MM cells, and the mechanism underlying the two-drug combination might involve regulation of the expression of several proteins affected by ATO and rmhTRAIL. Most motion estimation algorithms operate on image data that has been sampled in both space and time. We sought to examine whether variations in single nucleotide polymorphisms (SNPs) of circadian clock genes are associated with PA risk. Hermaphrodites have both sexes during their life, including an initial primary sex determination and in later stage maintenance one of the sexual fates (secondary sex determination). 26 patients presented with a one-vessel desloratadine dose pediatric disease (the infarct-related artery), 19 with a two- and 9 with a three-vessel disease. thermodilution cardiac output measurement during hepatic vascular exclusion in liver transplantation. Amphotropic murine leukemia virus (A-MuLV) utilizes the Pit-2 sodium-dependent phosphate transporter as a cell surface receptor to infect mammalian cells.

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To determine the value of social support interventions for work outcomes. Following block of GABA(A) receptors by bicuculline (20 microM) and of glycine receptors by strychnine (1 microM), regular bursting activity recorded from ventral roots developed spontaneously and persisted unchanged for many hours. The p21-activated kinase (PAK) family of serine/threonine protein kinases is activated by binding to the small (p21) GTP-binding proteins Cdc42 and Rac. Quality of life and adjuvant systemic therapy for early-stage breast cancer. Anorectal malformations are a rare condition difficult to diagnose in the prenatal period.

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To assess tumour control, hearing preservation status, and complication ratio after fractionated stereotactic radiosurgery/radiotherapy by using CyberKnife device in patients with vestibular schwannomas. Points M and P, blue xanax pill identifier which represented the position of the first premolar and second molar teeth, were positioned 20 mm apart on the casting. The role of complement in the antiphospholipid syndrome: a novel mechanism for pregnancy morbidity. This study aimed to determine the minimum electrogram recording duration that accurately characterizes CFAE or DF sites for ablation without unduly lengthening the procedure. The accessibility of our platform allows for subsequent recovery of targets for further analysis. Neuropsychological examinations performed simultaneously, allowed to evaluate the dynamics of central nervous system disfunction. However, it is unknown how viral persistence impacts T cell populations in mucosal sites. Shoe allergens: retrospective analysis of cross-sectional data from the north american contact dermatitis group, 2001-2004. These findings suggested that the interaction effect of acculturative stress and social constraints on psychological distress may be subject to cultural influences, and social constraints may have differential roles in Hispanics/Latinos and Asians. The second part of this serial paper reviews findings that are relevant for the ophthalmological community and highlights current scientific applications in this area.

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We assessed theory of mind (ToM) in unaffected first-degree relatives (FDR) of patients with schizophrenia (SC) and bipolar disorder (BD) compared to healthy controls with a revised computerized referential communication task. Experience with suspecting child maltreatment in the Norwegian public dental health services, a national survey. Here, we have attempted to show how glucocorticoids may generate a rapid anti-inflammatory response by promoting arachidonic acid-containing endocannabinoids biosynthesis. Neurology and Rehabilitation Departments together accounted for two-thirds of all hospital outpatient care. Changes in corticosteroid and catecholamine metabolism accompanying acute restrictions of mobility. The zoster vaccine boosts cell-mediated immunity to varicella-zoster virus, the virus that causes both varicella and herpes zoster. The lack of association between APOE epsilon 4 carrier status and mortality, or development of dementia, or cognitive decline in these very elderly people, whether analyzed in the whole population or among the nondemented subjects only, suggests that the APOE epsilon 4 effect in younger subjects is age-dependent, and that it is no longer present in very old age.

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In this study a Monte Carlo simulation model is utilized, in order to examine the effect of a wide range of focal spot sizes and three representative intensity distributions on spatial resolution under magnification. A total of 100 diabetics having hypertension and 50 non-hypertensive diabetic patients were enrolled on the basis of purposive sampling. The surveillance of effects on environment and human health is warranted to monitor the development. Detection of Bordetella holmesii using Bordetella pertussis IS481 PCR assay. One year follow-up showed a significant reduction in intraocular pressure in all lipitor 20mg generic cohorts.

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Connexin phosphorylation has been investigated in a variety of ways. CCN family 2/connective tissue growth factor (CCN2/CTGF) is an atypical growth factor for growth plate chondrocytes. The gene coding prilosec dosage infants for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. Resuscitation in acute respiratory insufficiency in the course of chronic lung diseases. Data from all the 16 regional blood transfusion centres were collected from the report annually presented by the different regions. Vbmp is an R package for Gaussian Process classification of data over multiple classes.

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Our technique of using in situ appendix without cecoplication requires minimal mobilization and manipulation of the blood supply. We also report the clinical and demographic characteristics of patients. The evaluation criteria are obtained from application scenarios in clinical research rather than patient care. There is an urgent need to re-establish the fundamentals of continence care into the practice of medical and nursing staff and action needs to be taken with regard to the establishment of truly integrated, quality services in this amaryl 4 mg tablet neglected area of practice. The Management of Patients with Colorectal Cancer and Synchronous Liver Metastases or Indeterminate Liver Lesions: A Community Teaching Hospital Experience. Measurements of TIV are independent of atrophy and can be used safely to adjust for differences in head size in studies of cerebral structure in AD. NADPH oxidases are at the center of these events, underlying the dysfunction of other oxidases including eNOS uncoupling, xanthine oxidase and mitochondrial dysfunction. It is shown that in the case of displayed ultrasound (US) image data the maximum likelihood (ML) estimator of the original (noiseless) signal closely resembles the L(2) mean which has been proven earlier to be the ML estimator of the original signal in US B-mode data.

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