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Angilock (Losartan)

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Angilock is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
Angizaar, Anreb, Czartan, Fensartan, Fortzaar, Gitox, Hizaar, Hypozar, Lacine, Lakea, Lepitrin, Loctenk, Logika, Loortan, Loplac, Lopress, Lortaan, Losagen, Losapot, Losartax, Losatan, Losium, Lotar, Lotim, Lozatan, Normatens, Osartan, Ozarium, Prelow, Rasertan, Repace, Rosatan, Simperten, Sortal, Tarnasol, Temisartan, Tensaar, Tensiohess

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Also known as: Losartan


Angilock (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Angilock is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Angilock is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Angilock 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Angilock 25 mg, Angilock 50 mg, and Angilock 100 mg may also contain carnauba wax.


Take Angilock tablets orally with or without food. Do not crush or chew it. Take Angilock once or twice a day at the same time. If you want to achieve most effective results do not stop taking Angilock suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Angilock are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Angilock as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Angilock. Correct volume or salt depletion prior to administration of Angilock.

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The ethical question on prolonging the life of a cancer patient -- a reply. Glycosaminoglycans, either obtained from fibroblasts cultures (conditioned media) or purified commercially available GAG were administered to 5/6-day chick embryo back skin explants. A significant correlation was found between sonact time and APTT, and between clot rate and APTT. The more reduced and condensed the matrixes are, the larger extent of competitive effect would the corresponding sediment show at a given sorbed volume of competitor. The standardized population prevalence of such disorders is reported and the predictors of having anxiety or depression were assessed using Poisson regression model. This discrepancy was resolved by recording a series of optical diffraction patterns when the original micrograph was immersed in oil. The study included nine normal nonsmoking subjects, ten normal smokers and 22 subjects with mild to moderately severe COPD. We assume that, along with the decrease in bladder capacity, a periureterally located Hunner lesion may be an important factor in the development of VUR.

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Principal component analysis indicates a correlation between carbohydrate composition of EPS fractions and the phylogenetic relationship of the respective species, indicating that EPS analyses under defined culture conditions may support taxonomic analyses. Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery. We hypothesized that high sensitivity C-reactive protein (hs-CRP) and the presence of renal artery stenosis (RAS) might conjointly predict future major adverse cardiovascular events (MACE) in patients with peripheral artery disease (PAD). The system was divided into three subsystems, the insulin subsystem, the glucose subsystem and the insulin-glucose interaction. The brainstem auditory evoked potential can be used to estimate the time of brain death. Mechanisms underlying the improvement of arterial oxygenation using positive end-expiratory pressure during surgery under sevoflurane anesthesia and propofol anesthesia: a retrospective clinical study. Wray were reexamined and redescribed where necessary from type material and other specimens. Contraction kinetics of smooth-muscle preparations (rat portal vein, rat tracheal muscle) were studied by means of force-velocity relations obtained from after-loaded isotonic contractions or from the analysis of the isometric tension increase. Adherence success in sub-Saharan Africa can be explained as a means of fulfilling social responsibilities and thus preserving social capital in essential relationships.

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As shown by isoelectric focusing, the enzyme became more heterogeneous at day 20 than at day 18, suggesting increased glycosylation. A multicentre, pragmatic, two-armed randomised controlled trial with an economic evaluation. This approach requires an understanding of the biosynthetic pathway of each target sugar and detailed mechanistic knowledge of the key enzymes. Retrograde infusion of parotid-amylase solution into excretory ducts of the parotid gland elevated the activity of the enzyme in the serum. Each MRI was then independently quantified for measures of brain, white matter hyperintensities, and hippocampal volumes by a technician blind to subject age, sex, ethnicity, race, and diagnostic category. Time of service moderated the relationship between disability status and change in internalized stigma, such that veterans serving in the more recent Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) cohort who received disability benefits had a more difficult time resolving internalized stigma. When is the best time to deliver behavioral intervention to bariatric surgery patients: before or after surgery?. The present single-molecule observations yielded the actual phase structure that controls the motion of molecules in the membrane. The surgical management of pilonidal disease ranges from minimally invasive techniques to wide excision with secondary wound healing.

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Simulation-based perioperative team training with anesthesiologists, obstetricians, and operation nurses may serve as a vehicle to promote perioperative obstetrics patient safety. Developmentally regulated plant genes: the nucleotide sequence of a wheat gliadin genomic clone. Superior laryngeal and cricothyroid motoneurons were present only in the retrofacial nucleus, while recurrent laryngeal motoneurons were present in both the nucleus ambiguus and the retrofacial nucleus. gingivalis-reactive humoral immune system in saliva is, however, activated. Clotting, microembolism, and inhibition of fibrinolysis in adult respiratory distress. For passive applications, we directly compare the efficiency and power consumption of saturable absorbers (SAs) based on SWCNT with SA based on conventional multiple quantum wells. Persistent effects after trigeminal nerve proprioceptive stimulation by mandibular extension on rat blood pressure, heart rate and pial microcirculation. Here we demonstrate experimentally that the non-photoperiodic factors responsible for large and consistent differences in the expression of natural breeding responses between three captive outdoor blue tit populations are ignored during long-day treatment.

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CD55 is widely localized in the cholesterol rich regions of the cell plasma membrane termed membrane rafts. In tight esophageal strictures, the surgical methods of dilatation occasionally become difficult or impossible. Mechanisms for bicarbonate-dependent regulation of intracellular pH. The mutation of UNC-33, a Caenorhabditis elegans homolog of CRMP-2, results in abnormality of microtubules in neurites, but the mechanism of CRMP-2 action remains to be clarified. Further studies of the clinical anatomy of the craniocervical region. The observed effect might be connected with a rise in the activity of kininogenic enzymes in the central nervous system. To investigate the effects of elevated glutamate levels on cGMP in the developing cortex we exposed mouse brain slices to glutamate or N-methyl D-aspartate (NMDA). To investigate sensory function, visual, auditory and somatosensory evoked potential and imaging studies were carried out. Here we report the use of surface molecular adsorption to induce ferromagnetism in two-dimensional superconducting NbSe2, representing the freestanding case of the coexistence of superconductivity and ferromagnetism in one two-dimensional nanomaterial. However, the results do not confirm our hypothesis that lymphoscintigraphy can reveal differences in lymph circulation that are not evident clinically in the form of manifest lymphedema.

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The effect of antigen concentration and vaccine regimen on the immunity induced by membrane antigens from the midgut of Boophilus microplus. This issue warrants future investigations aimed at improving oral health and preventing oral degenerative diseases using molecular and experimental approaches currently utilized in mutagenicity studies. Data from the Rett Syndrome Networked Database on 1,248 female patients were included. A nanocapsule is a vesicular system that exhibits a typical core-shell structure in which active molecules are confined to a reservoir or within a cavity that is surrounded by a polymer membrane or coating. Smad7 gene transfer suppresses fibrogenic responses to TGF-beta2 by retinal pigment epithelial cells in vitro and in vivo. Heavy metal mobility in intertidal sediments of the Scheldt estuary: Field monitoring. Procedural complication risks should be considered when choosing the best approach.

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We addressed the potential role of PbGel3p in cell wall biosynthesis and morphogenesis by assessing its ability to rescue the phenotype of the Saccharomyces cerevisiae gas1Delta mutant. Cardiac output determination by the thermodilution method: comparison of ice-temperature injectate versus room temperature injectate contained in prefilled syringes or a closed injectate system. Sarcopenia is an independent risk factor of dysphagia in hospitalized older people. 130 K, 68 K and 60 K with varying specificity to Col IV of basement membrane and Col I of stroma, their selective inhibition by TIMP and proteoglycans and modulation by estrogen highlight the importance of these in the remodeling of the ECM in the mammary gland. Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia. DNA damages were assessed by alkaline single-cell gel electrophoresis. Structure of the bovine ACAD8 gene and the association of its polymorphism with the production traits. A three-dimensional photoacoustic imaging method is presented that uses a Mach-Zehnder interferometer for measurement of acoustic waves generated in an object by irradiation with short laser pulses.

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In myeloma patients, transcriptionally active myeloma nuclei were incorporated into osteoclasts through fusion. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. These latter represent the division phase of glioblasts detached from the ventricular surface. Pollen dispersal and breeding structure in a hawkmoth-pollinated Pampa grasslands species Petunia axillaris (Solanaceae). Postnatal depression, a mother-infant-social environment interaction pathology?. The increased threat of radiological terrorism and accidental nuclear exposures, together with increased usage of radiation-based medical procedures, has made necessary the development of minimally invasive methods for rapid identification of exposed individuals. For macromolecular crystallography to be successful, structure-quality crystals of the target protein must be forthcoming, and crystallogenesis represents a major challenge.

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Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. Subsequent exposure of A431 cells to 1,2-NQ or 1,2-NQH2-SAc caused an extensive chemical modification of cellular proteins in both cases. In order to what medicine is zantac better understand the underlying biological mechanism/s involved in autism, it is important to investigate the cognitive and behavioural phenotypes associated with idiopathic autism (autism without a known cause) and comorbid autism (autism associated with known genetic/biological disorders such as fragile X syndrome). Analysis of surgical treatment of patients with carotid artery stenosis endarterectomy versus stenting. Usefulness of myocardial ischemia as predictor of training effect in cardiac rehabilitation after acute myocardial infarction or coronary artery bypass grafting. In contrast, electrophilic compounds with an acidic C-terminal group or a cyclic P1 residue showed a lower inhibitory effect at pH 8 than at pH 6, inconsistent with a mechanism-based inhibition. Cellular experiments indicated that increased citrate levels might originate from an excess of fatty acids. Serum insulin concentration in horses: Effect of storage and handling. Marjolin ulcer arising within hidradenitis: a case report and literature review.

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Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Imaging neonates and children with Pierre Robin sequence before and after mandibular distraction osteogenesis: what the craniofacial surgeon wants to know. According to our early experience, radiofrequency ablation of inoperable pancreatic tumors is relatively save cytoreductive procedure. Activity of a proteinaceous polygalacturonase inhibitor in potato plants. noctilucae is distantly related to the type species of Pedinomonas. The aim of this study is to investigate the effects of an individualized yoga intervention. An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. This may be one of the mechanisms by which hypertension is carried over into the waking hours in patients with OSA.

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Many pathogenesis-related proteins are expressed by plants during the attack of pathogens. Hormone replacement therapy to maintain cognitive function in women with dementia. This suggests that the contraction of at least some glimepiride medication interactions segments of the polypeptide chain may be facilitated only by contraction of other segments. Thermotropic phase behavior of model membranes composed of phosphatidylcholines containing dl-methyl anteisobranched fatty acids. Clinical utility of five genetic variants for predicting prostate cancer risk and mortality. Psycho-behavioural analysis of occupational dermatitis patients before starting treatment is recommended. This study was carried out to evaluate the antidepressant effect and isolate the potential antidepressant constituents of the polar extract of N. The study showed the good psychometric properties of the new Italian version of the EDE-Q 6.0, and validated its use in Italian eating disorder patients, particularly in young females with anorexia nervosa.

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Noradrenaline induced only K uptake at a low concentration (3 X 10(-7) M), but induced transient K release followed by marked K uptake at higher concentrations (3 X 10(-6) to 3 X 10(-4) M). Prevalence of subclinical Salmonella enterica infection in Danish finishing pig herds. Predisposing factors including age, female gender and schooling were independently associated with edentulism. Atrazine, one of the most common pesticide contaminants, has been shown to up-regulate aromatase activity in certain estrogen-sensitive tumors without binding or activating the estrogen receptor (ER). An extensive network of SPI fibers of varying densities were identified throughout the lower brainstem.

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