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Antidep (Imipramine)

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Antidep works by inhibiting the reuptake of certain neurotransmitters in the brain, including acetylcholine, dopamine, norepinephrine, and serotonin. It also acts on certain other receptors, such as H1 receptors for histamine. Antidep usually is administered orally but may be given by intramuscular injection.

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Also known as: Imipramine


Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Tell your doctor if you have a planned surgery.

Call your doctor if your symptoms do not improve, or if they get worse.

You should not stop using Antidep suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Detailed Antidep dosage information


If you overdose Generic Antidep and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Antidep overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Antidep-PM dosage information

Side effects

The most common side effects associated with Antidep are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Antidep if you are allergic to it, or if:

you recently had a heart attack; or you are allergic to other antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trAntidep).

Do not use Antidep if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

heart disease, stroke, or seizures; bipolar disorder (manic-depression), schizophrenia or other mental illness; kidney or liver disease; overactive thyroid; narrow-angle glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

It is not known whether Antidep will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Antidep.

Do not give this medicine to a child without medical advice. Antidep is not approved to treat depression in anyone younger than 18 years old. This medicine should not be used to treat bed-wetting in a child younger than 6 years old.

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