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Anxidep

Anxidep, synthetic drug used in the treatment of depression and enuresis (bed-wetting). Introduced into medicine in the late 1950s, Anxidep was the first tricyclic antidepressant, a class named for its three-ring molecular structure.

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Also known as: Imipramine

Description

Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Anxidep-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Anxidep can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Anxidep-PM dosage information

Side effects

The most common side effects associated with Anxidep are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Anxidep if you are allergic to it, or if:

you recently had a heart attack; or you are allergic to other antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trAnxidep).

Do not use Anxidep if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

heart disease, stroke, or seizures; bipolar disorder (manic-depression), schizophrenia or other mental illness; kidney or liver disease; overactive thyroid; narrow-angle glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

It is not known whether Anxidep will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using Anxidep.

Do not give this medicine to a child without medical advice. Anxidep is not approved to treat depression in anyone younger than 18 years old. This medicine should not be used to treat bed-wetting in a child younger than 6 years old.

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A target-based patient-selection strategy is expected to eventually lead to tailored therapy for lung cancer. CCR7 selection offers a means to enrich T cells of early differentiation status for ACTC. Synthesis, microbicidal activity, and solution structure of the dodecapeptide from bovine neutrophils. Aflibercept as primary treatment for myopic choroidal neovascularisation: a retrospective study. Literature search yielded six comparative studies, among which five were included for this review. A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system. The modified bilateral transfrontal sinus craniotomy provides excellent access to the canine olfactory bulbs and frontal lobes. Genetic background is more important than adjuvants in determining the nature of EC and immunity.

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Three months later, she noticed periorbital pain and blurred vision in her left eye, although the right temporal headache was reduced. The top three gynecological diseases in children are ovarian tumors, reproductive tract dysplasia or malformation, and adolescent dysfunctional uterine bleeding. The patients were submitted to a modified version of Reed and Farah Test (1995), a test that taps the ability to encode changes of body position as opposed to changes of position of objects. We demonstrate that a tissue cable containing grafted SCs formed an effective bridge between the two stumps of the hemicord 1 month after transplantation. Next, we propose novel approaches for multidisciplinary prevention and intervention strategies to promote breastfeeding, and examine interactions between psychology and the environment. Pilot study of transesophageal endoscopic epicardial coagulation by submucosal endoscopy with the mucosal flap safety valve technique (with videos). Structure-based virtual screening and cell-based assays were used to identify five small molecules that can inhibit canonical Wnt signaling and have low IC50 values in the micromolar range.

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Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein. feeding arterioles, nutritive capillaries and draining postcapillary venules, during reperfusion. Eight of the 9 fungi were eradicated, and no patient became hemodynamically unstable on treatment. Re-dislocation after corrective osteotomy for chronic dislocation of the radial head in children. Five cases had type 1 pattern (sclerosis, fragmentation, and no fracture), 5 cases had type 2 pattern (undisplaced fracture and fragmentation), and 12 cases had type 3 pattern (displaced fracture and fragmentation). CNS-injected cells could be detected 3 mo after transplantation and were shown to produce the transgene product by immunocytochemistry and ELISA of tissue fluids.

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These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes. Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells: A Randomized Controlled Trial. In the ischemic hemisphere, NF-kappaB was activated, as determined by increased expression of an NF-kappaB-driven reporter transgene, nuclear translocation of NF-kappaB in neurons and enhanced DNA binding of NF-kappaB subunits RelA and p50. Fish from pristine areas were compared with those fishes from impacted environments, both by volcanic and anthropogenic activities. In each case SQ can preferentially select from the MDDR database other compounds with the same activity as the probe. The yield strength and ultimate strength of cortical and cancellous bone tissue are very highly correlated to bone stiffness. In orthotopic liver transplantation (OLT), the critical shortage of organ donors is the reason for accepting marginal donors. Several mutational studies have addressed the question of whether tight packing interactions are present during the rate-limiting step of folding. Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans. A cadaveric study, a computed tomography-based computer modeling study, and a clinical study using a navigation system were conducted to document these changes.

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Twelve pigs were divided into four groups of three animals each. X-ray fluorescence induced by standing waves in the grazing-incidence and grazing-exit modes: study of the Mg-Co-Zr system. The atomistic simulations are based on an accurately parametrized force field, specifically designed to represent the conformational behavior of the molecule in its ground and bright excited states, whereas TDDFT calculations are performed through a selected combination of hybrid functionals and basis sets to obtain optical spectra closely matching the experimental findings. A 26-year-old man presented with dyspnea on exertion and pleuritic pain since the day before. Therefore, we review some commonly used mouse models and discuss their advantages and disadvantages. In DNA strand displacement, leaky reactions can cause DNA signals decay and detecting DNA signals fails. Effects of nitrosomethylurea and nitrosomethylurethan on the physical chemical properties of DNA. Here, we report an unexpectedly large acceleration in the effective heterogeneous OH reaction rate in the presence of NO. Moreover direct immunoregulatory effects exerted by the drug may be important in influencing the complex balance of pro-inflammatory mechanisms during active intestinal inflammation.

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