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Apalene (Adapalene)

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Apalene and Apalene (Retin-A) are different medications, but they are both used to treat mild-to-moderate acne. Apalene contains adapalene, and Retin-A contains Apalene. They both offer a range of benefits and options, so talk to your healthcare provider to discuss which one would be the best fit for you.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Fosamax, Lioresal, Aristocort, Strattera, Mysoline

Also known as: Adapalene


Apalene is a third-generation topical retinoid primarily used in the treatment of acne. Apalene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Apalene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Apalene works under the skin surface to unclog pores and clear up pimples. Apalene is also known as Adapalene, Adapen, Adaferin. Generic name of Apalene is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Apalene and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Apalene dosage information

Side effects

The most common side effects associated with Apalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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First, the standardization of medical skills of medical professionals is greatly affected due to the presence of different education systems for the same medical profession except for medical doctors and pharmacologists. The morphology and ultrastructure of the thawed tracheal fragments including HE dyes, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL) staining, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were studied to assess the integrity of the tracheal fragments. Current report--HIV 1989 International Conference on AIDS--Montreal. Correction: Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation. Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus. Normogastrinemic antrectomized and sham operated animals were studied as controls. Environmental agents induce intragenic alterations in the FRA3B/FHIT chromosome fragile site, resulting in fragile FHIT allele loss early in cancer development.

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Phogrin formed a complex with insulin receptor at the plasma membrane, and their interaction was promoted by high-glucose stimulation that in turn led to stabilization of IRS2 protein. We show that its putative product is related to transposases of the Tc1/mariner superfamily, being closer to the pogo family. The activation of autolysis and normalization of the protein amide groups content were not observed in brain of old animals under conditions of starvation. Influence of starvation on heart contractility and corticosterone level in rats. Helicoid ventricular tachycardia, torsade de pointes, in acute myocardial infarction. The leukoencephalopathy was present in all Nrf2-null mice more than 10 months of age, was characterized by vacuolar degeneration involving all major brain regions, and was most apparent in the white tracts of the cerebellum and pons. In addition, we established that the SPOC kinase Kin4 is the major regulator of Bfa1 residence time at SPBs. Therefore, a possible causal link between BSPs and ECR could be drawn. Data from these training studies strongly support the practice of training with overweight and underweight baseballs to increase throwing velocity of regulation baseballs.

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Loop dynamics of the extracellular domain of human tissue factor and activation of factor VIIa. We labeled it with FITC to observe whether it could bind prostate cancer PC-3 cell lines, and meanwhile used it as a non-viral gene delivery carrier with the plasmid pEGFP-N1 that could express GFP in PC-3 cells. Analysis of transgenic Arabidopsis plants showed that overexpression of AGL18 produces the same phenotypic changes as overexpression of AGL15, and the two genes have partially overlapping expression patterns. The development of a common standardized data set that can be evaluated with regard to data quality, comparability and reporting rates is likely to optimize ADE data and drug safety surveillance. We examined the effects of gallbladder mucosal lipid absorption on lipid composition and cholesterol crystallization in bile. Three cases were brain surgeries and four cases were abdominal surgeries. In the present study, we analyzed all the pathogenic non-horizontally transferred genes of V. Stereoselective Combinatorial Ugi-Multicomponent Synthesis on Solid Phase This work was supported by the Deutsche Forschungsgemeinschaft and by the Fonds der Chemischen Industrie.

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Estimated human excretion rates of natural estrogens calculated from their concentrations in raw municipal wastewater and its application. Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis. The potential to enhance continuity by scaffolding was tested using 454 sequences from circularized genomic fragments. Vertical rupture in posterior corneal layers after cataract extraction. To explore the operative rate and reoperative rate of Crohn disease(CD) in China, and to assess the relative risk factors indicating surgical treatment in CD patients. A bifunctional invertebrate-type lysozyme from the disk abalone, Haliotis discus discus: genome organization, transcriptional profiling and biological activities of recombinant protein. Association of Objectively Measured Physical Activity and Metabolic Syndrome Among US Adults With Osteoarthritis. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Thirteen lines developed from the crosses between high yielding cultivars with aromatic low yield ones based on pedigree breeding method.

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Dust-bathing behavior of laying hens in enriched dogs imodium dose colony housing systems and an aviary system. A calcium-dependent lectin is the principle mediator of binding to the high endothelial venule of lymph nodes. We argue that the distinction between the two ways that freedom of conscience is exercised (avoiding a perceived evil and seeking a perceived good) provides a rational basis for a principled limitation of this fundamental freedom. In the official prescription information in the United States, the United Kingdom, and Denmark repeated dosing of all seven oral triptans are recommended for headache recurrence but some triptans are also recommended for no or partial response, a use of a triptan deemed to be not beneficial in European and Canadian migraine guidelines. Bladder lymphoma: diagnosis and documentation of response by magnetic resonance imaging. Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis. Deletion of the YY1-binding site from the retroviral genome leads to a major loss of silencing in embryonic cells and a coordinated loss of repressive histone marks from the proviral chromatin. Treating internal resorption using a syringeable composite resin. Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy. Lung volume reduction surgery usually gives rise to high postoperative morbidity and impedes its further application.

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