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Aprical (Nifedipine)

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Aprical is used to treat high blood pressure or angina (chest pain). For high blood pressure: Aprical works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Aprical works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Aprical. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Aprical and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Aprical are:

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Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Because of the high rate of infection in the homeless population, routine screening for TB and preventive therapy for eligible persons should be considered in shelters. Preparation and characterization of radioactive dirhenium decacarbonyl-loaded PLLA nanoparticles for radionuclide intra-tumoral therapy. Observation of Autoregulation Indices During Ventricular CSF Drainage After Aneurysmal Subarachnoid Hemorrhage: A Pilot Study. L-NAME and packed erythrocytes dose-dependently decreased progressive sperm motility. Densitometric analysis of acetylcholinesterase bands provided additional objectivity in classifying band density. These data suggest that elastase from macrophage may be mainly related to nitrogen dioxide-induced lung injury. An experimental model is described for analysis of cellular and molecular mechanisms involved in the modulation of tumorigenicity by syngeneic lymphoid cells and oncofetal products in vivo. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts.

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Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach. Determinants of shortened, disrupted, and mistimed sleep and associated metabolic health consequences in healthy humans. This review presents the role of strigolactone transport in regulating plant root and shoot architecture, plant-fungal symbiosis and the crosstalk with several phytohormone pathways. Complex dislocation of the little finger metacarpophalangeal joint is very rare. We report increased expression and activity of both sphingosine kinases and S1P phosphatases during development of the mouse metanephric kidney from induction at embryonic day 11.5 to maturity. Statistically significant differences in data concerning perikaryon volume, perikaryon surface and intracellular organelle composition (volume densities and absolute volumes) are found. Human thyroglobulin has been shown for the first time to bind to the surface of cultured human thyroid follicular cells. Dopamine agonists are indicated as primary therapy for PRL-secreting pituitary adenomas, while controversial results have been reported in nonfunctioning adenomas (NFA). Circle of Willis Collateral During Temporary Internal Carotid Artery Occlusion I: Observations From Digital Subtraction Angiography.

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Pulmonary complications subsequent to fractured neck of the femur in the elderly. Osmotic forces driving water reabsorption in the proximal tubule of the rat kidney. Further research is needed to define the optimal organ-allocation system for pediatric heart transplantation. Thus BAY 41-2272 protects against I/R-induced lung injury by interfering with the activation of NADPH oxidases. Purified Std fimbriae and UEA both bound to a receptor localized in the mucus layer of the murine cecum. The ability of acidic phospho- and sphingolipids to interact with basic proteins was studied by double diffusion analysis. The GG genotype of Cdx2-VDR gene polymorphism may increase the risk of developing breast cancer in young female patients in South Pakistan. Two new species of the genus Myrmarachne are described (Myrmarachne acutidens sp. We have mapped out the ectosylvian visual area (EVA) of the cat in a series of single- and multiunit recording studies.

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Internal resorption is a pathological process initiated within the pulp space with the loss of dentin. On the basis of this information a simplified computer simulation model involving lumped tissue parameters has been created to study the heat diffusion process during stimulation. The corresponding class I molecules reacted differentially with monomorphic monoclonal antibodies (m.Ab). The patient was a 78-year-old male who died in ventricular fibrillation. The contrast in these photoelectron micrographs is primarily topographical in origin, and the presence of fluorescent dyes at low density does not contribute significantly to the material contrast. Intestinal injury and bleeding, which usually occurs while taking the graft through the transperitoneal tunnel, is one of the most important complications of aortobifemoral bypass surgery. Pulmonary capillaritis has been described in adult lung transplant recipients, but has not been previously reported in pediatric recipients. Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. Removal of radioactive caesium from low level radioactive waste (LLW) streams using cobalt ferrocyanide impregnated organic anion exchanger. Using the activPAL as the reference criteria, we compared classification of sedentary time to hip-worn and wrist-worn ActiGraph accelerometers over a range of cutoff points for both 60-s and 15-s epochs.

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The basic helix-loop-helix (bHLH) transcription factor Twist plays a role in mesodermal development in both invertebrates and vertebrates. Lucy Wills (1888-1964): the life and research of an plavix dosage time adventurous independent woman. Basal TSH and the difference between stimulated and basal TSH did not correlate with prolactin levels. Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts. p27Kip1 is inactivated in human colorectal cancer by cytoplasmic localization associated with activation of Akt/PKB. After 3-4 days, the sections of SNr injection site and MD nucleus were prepared. Patients including the elderly show a good degree of tolerability with a low complication rate. The present data suggest that NIRS is a feasible tool for assessing brain activation during endoscopic surgical tasks, and may have a large impact on the future development of teaching, training, and assessment methods for endoscopic surgical skills. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Tailup plays multiple roles during cardiac outflow assembly in Drosophila.

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We evaluated here the use of plasma exchange (PE) therapy and kidney retransplantation in NPHS1 patients with recurrent NS and extended our studies on the pathogenesis of the recurrence. The BITS2012 meeting, held in Catania on May 2-4, 2012, brought together almost 100 Italian researchers working in the field of Bioinformatics, as well as students in the same or related disciplines. Our objectives are to (1) quantify and describe the population of young adult patients with congenital or childhood-acquired urologic problems who continue to be followed in pediatric urology clinic, to (2) discuss the numerous obstacles to successful care transition, and to (3) outline the design features of the dedicated transition clinic we established in response to the identification of a sizeable population in need. This pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness anafranil dose dermal wounds in healthy individuals. To assess the impact of pressure from the table top and patient position on the relationship of the prostate, rectum, and bladder to the bony pelvis. A patient with all four major features of narcolepsy following significant head injury is presented. Newer investigations using the compound capsaicin are consistent with the hypothesis that substance P is an important neurochemical mediator of certain kinds of noxious peripheral stimuli. To evaluate the role and safety of biopsy of the seminal vesicles and neurovascular bundles in determining the pathologic stage of prostatic carcinoma. Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Muscular dystrophy is characterized by skeletal muscle weakness and wasting, but little is known about possible alterations to the vasculature.

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Schizophrenia may therefore qualify as a model disorder to test neural correlates of gesture impairments. The second species of RNA appears to be a full length copy of one strand of the double-stranded RNA genome. Clinicians providing care to community dwelling elders are advised to evaluate and attend to both the depressive symptoms and SRH of their patients. Human colonic mucosa was immunostained with antibodies against substance P to identify the endocrine cells containing this peptide in the mucosal glands. The robust response achieved with the mIGF-1 isoform provides a mechanistic basis for clinically feasible therapeutic strategies for improving the outcome of heart disease. The goal of present study was to compare the pharmacokinetic profiles of single-dose administration of an FDC tablet containing rosuvastatin/olmesartan 20/40 mg (test formulation) with coadministration of a rosuvastatin 20-mg tablet and a olmesartan 40-mg tablet (reference formulation) in healthy Korean male volunteers, for the purpose of determining bioequivalence. Since the report of the first adenylyl cyclase (AC) gene in 1989, tremendous efforts have been devoted to identifying and characterizing more AC isozymes. First report on meiotic behavior of chromosomes in three actos dose adjustment species of subfamily Pentatominae (Pentatomidae: Heteroptera).

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Autonomic dysreflexia-induced reversible posterior leukoencephalopathy syndrome in patients with spinal cord injury: two case reports. In this paper we describe the obtention of PWMs for sites, and the Markov model of coding DNA in Drosophila melanogaster. Finite element models were used to simulate the propagation of lithotriptor shock waves in human renal calculi in vivo. The systemic inflammatory response syndrome-based sepsis definition offers little value in identification of children at high risk of in-hospital mortality in this setting. Cross-talk between integrins and oncogenes modulates chemosensitivity. An efficient Ullmann-type reductive homocoupling of aryl, vinyl and heteroaryl halides can be promoted by an aldehyde in tetraalkylammonium ionic liquids under very mild reaction conditions.

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The dimensionality of conjugated polymer systems plays an important role in energy-transfer processes, and 1D and 2D energy transfer of excitations are typically much slower than that between pi-stacked chains within a 3D polymeric solid. The ESH-IP revision 2010 for validation of BP measuring devices in adults was followed precisely. This study aimed to examine whether muscle activation of the quadriceps femoris differs between single- and multi-joint exercises, and to explore the factors resulting in muscle and exercise specificity in activation. This phase 2 study evaluated the benefits and tolerability of weekly intravenous and intraperitoneal paclitaxel (PTX) treatment combined with oral S-1 in patients with gastric cancer who had macroscopic peritoneal metastasis. Whether homozygotes or heterozygotes, all subjects displayed microcytosis (with various degrees of poikilocytosis) and a moderately depressed alpha-globin chain synthesis. At the end of the permeation experiments levothyroxine retained in the skin was extracted and quantified by HPLC. However, tumor regrowth occurred after the operation (doubling time, 8.36 days) and spinal dissemination was detected. The purpose of the following care plan is to familiarize the nurse with the information needed to restore catheter patency efficiently, safely, and effectively, thereby reducing the potential complications and enhancing the quality of patient care. In layer III of the densely labeled region, patches of high concentrations of labeled callosal axon terminals correspond with high concentrations of labeled callosal cell bodies. Establish whether the Sbisa bar, Bagolini filter (BF) bar, and neutral density filter (NDF) bar, used to measure density of suppression, are equivalent and possess test-retest reliability.

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When the splenocytes from RW-primed WT mice were transferred into IL-10 KO or WT mice, the IL-10 KO mice showed significantly less conjunctival eosinophil infiltration. To determine whether the endoplasmic reticulum stress participates into the apoptosis process of the retina during experimental retinal detachment-by detecting the level of mRNA and protein of the GADD153, the marker of endoplasmic reticulum stress. Approaching usability: a study of an academic health sciences library web site. Parotid duct sialocele is a salivary cavity arising at the expense of parotid duct. Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. Importantly, this technique enables the testing of hypotheses on the listening strategies of participants at the group level. Isolated anterior cruciate ligament deficiency, knee scores and function. In this comparison of three surgical techniques for the correction of PSW, it was demonstrated that each choice is safe, with no option showing a significant difference in complication rate. We compared the 2005 CI to the 2004 CI, representing the years before and after the nets were used.

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Craniomaxillofacial fibrous dysplasia albenza drug : conservative treatment or radical surgery?. Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. Taken together, these results indicate that YlOCH1 plays a key role in the outer-chain mannosylation of N-linked oligosaccharides in Y. Kindlin-2 has been known as a focal adhesion molecule that binds to integrin to control cell migration and invasion. Clinicians should be encouraged to perform LP in suspected bacterial meningitis. Improving accuracy for identifying related PubMed queries by an integrated approach. A recently developed computer program for three-dimensional (3D) reconstruction of SPECT images has been employed to study myocardial perfusion in coronaropathic patients using MIBI-99mTc or 201Tl chloride. Unexpectedly, all cases demonstrated cell surface Tac antigen, which previously had been restricted predominantly to select T-cell malignancies and activated T cells. Fibrous reconnection and contraction of the scar can be minimized in this way, which may be the clinical efficacy explanation.

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