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Aprical (Nifedipine)
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Aprical

Aprical is used to treat high blood pressure or angina (chest pain). For high blood pressure: Aprical works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Aprical works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Addos, Adefin, Adipine, Afeditab, Buconif, Calcheck, Calcianta, Calcibloc, Calcigard, Cardifen, Cardiosol, Cardules, Casanmil, Cordafen, Cordilat, Corotrend, Epilat, Farmalat, Ficard, Herlat, Jutadilat, Nedipin, Nefelid, Nelapine, Nicardia, Nidicard, Nidilat, Nidipine, Nifcal, Nifebene, Nifeclair, Nifedate, Nifedigel, Nifedin, Nifedipino, Nifedipress, Nifelat, Nifelong, Nifeslow, Nirena, Nyefax, Oxcord, Siopelmin, Tenif, Tensomax, Tredalat

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Aprical. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Aprical and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Aprical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach. Determinants of shortened, disrupted, and mistimed sleep and associated metabolic health consequences in healthy humans. This review presents the role of strigolactone transport in regulating plant root and shoot architecture, plant-fungal symbiosis and the crosstalk with several phytohormone pathways. Complex dislocation of the little finger metacarpophalangeal joint is very rare. We report increased expression and activity of both sphingosine kinases and S1P phosphatases during development of the mouse metanephric kidney from induction at embryonic day 11.5 to maturity. Statistically significant differences in data concerning perikaryon volume, perikaryon surface and intracellular organelle composition (volume densities and absolute volumes) are found. Human thyroglobulin has been shown for the first time to bind to the surface of cultured human thyroid follicular cells. Dopamine agonists are indicated as primary therapy for PRL-secreting pituitary adenomas, while controversial results have been reported in nonfunctioning adenomas (NFA). Circle of Willis Collateral During Temporary Internal Carotid Artery Occlusion I: Observations From Digital Subtraction Angiography.

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Pulmonary complications subsequent to fractured neck of the femur in the elderly. Osmotic forces driving water reabsorption in the proximal tubule of the rat kidney. Further research is needed to define the optimal organ-allocation system for pediatric heart transplantation. Thus BAY 41-2272 protects against I/R-induced lung injury by interfering with the activation of NADPH oxidases. Purified Std fimbriae and UEA both bound to a receptor localized in the mucus layer of the murine cecum. The ability of acidic phospho- and sphingolipids to interact with basic proteins was studied by double diffusion analysis. The GG genotype of Cdx2-VDR gene polymorphism may increase the risk of developing breast cancer in young female patients in South Pakistan. Two new species of the genus Myrmarachne are described (Myrmarachne acutidens sp. We have mapped out the ectosylvian visual area (EVA) of the cat in a series of single- and multiunit recording studies.

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Autonomic dysreflexia-induced reversible posterior leukoencephalopathy syndrome in patients with spinal cord injury: two case reports. In this paper we describe the obtention of PWMs for sites, and the Markov model of coding DNA in Drosophila melanogaster. Finite element models were used to simulate the propagation of lithotriptor shock waves in human renal calculi in vivo. The systemic inflammatory response syndrome-based sepsis definition offers little value in identification of children at high risk of in-hospital mortality in this setting. Cross-talk between integrins and oncogenes modulates chemosensitivity. An efficient Ullmann-type reductive homocoupling of aryl, vinyl and heteroaryl halides can be promoted by an aldehyde in tetraalkylammonium ionic liquids under very mild reaction conditions.

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The dimensionality of conjugated polymer systems plays an important role in energy-transfer processes, and 1D and 2D energy transfer of excitations are typically much slower than that between pi-stacked chains within a 3D polymeric solid. The ESH-IP revision 2010 for validation of BP measuring devices in adults was followed precisely. This study aimed to examine whether muscle activation of the quadriceps femoris differs between single- and multi-joint exercises, and to explore the factors resulting in muscle and exercise specificity in activation. This phase 2 study evaluated the benefits and tolerability of weekly intravenous and intraperitoneal paclitaxel (PTX) treatment combined with oral S-1 in patients with gastric cancer who had macroscopic peritoneal metastasis. Whether homozygotes or heterozygotes, all subjects displayed microcytosis (with various degrees of poikilocytosis) and a moderately depressed alpha-globin chain synthesis. At the end of the permeation experiments levothyroxine retained in the skin was extracted and quantified by HPLC. However, tumor regrowth occurred after the operation (doubling time, 8.36 days) and spinal dissemination was detected. The purpose of the following care plan is to familiarize the nurse with the information needed to restore catheter patency efficiently, safely, and effectively, thereby reducing the potential complications and enhancing the quality of patient care. In layer III of the densely labeled region, patches of high concentrations of labeled callosal axon terminals correspond with high concentrations of labeled callosal cell bodies. Establish whether the Sbisa bar, Bagolini filter (BF) bar, and neutral density filter (NDF) bar, used to measure density of suppression, are equivalent and possess test-retest reliability.

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When the splenocytes from RW-primed WT mice were transferred into IL-10 KO or WT mice, the IL-10 KO mice showed significantly less conjunctival eosinophil infiltration. To determine whether the endoplasmic reticulum stress participates into the apoptosis process of the retina during experimental retinal detachment-by detecting the level of mRNA and protein of the GADD153, the marker of endoplasmic reticulum stress. Approaching usability: a study of an academic health sciences library web site. Parotid duct sialocele is a salivary cavity arising at the expense of parotid duct. Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. Importantly, this technique enables the testing of hypotheses on the listening strategies of participants at the group level. Isolated anterior cruciate ligament deficiency, knee scores and function. In this comparison of three surgical techniques for the correction of PSW, it was demonstrated that each choice is safe, with no option showing a significant difference in complication rate. We compared the 2005 CI to the 2004 CI, representing the years before and after the nets were used.

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Craniomaxillofacial fibrous dysplasia albenza drug : conservative treatment or radical surgery?. Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. Taken together, these results indicate that YlOCH1 plays a key role in the outer-chain mannosylation of N-linked oligosaccharides in Y. Kindlin-2 has been known as a focal adhesion molecule that binds to integrin to control cell migration and invasion. Clinicians should be encouraged to perform LP in suspected bacterial meningitis. Improving accuracy for identifying related PubMed queries by an integrated approach. A recently developed computer program for three-dimensional (3D) reconstruction of SPECT images has been employed to study myocardial perfusion in coronaropathic patients using MIBI-99mTc or 201Tl chloride. Unexpectedly, all cases demonstrated cell surface Tac antigen, which previously had been restricted predominantly to select T-cell malignancies and activated T cells. Fibrous reconnection and contraction of the scar can be minimized in this way, which may be the clinical efficacy explanation.

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