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Aratan (Losartan)

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Aratan and associated names, 12,5 mg, 25mg, 50 mg, 100 mg, film-coated tablets is an orally active angiotensin II (Ang- II) receptor antagonist, Aratan, acting on the AT1 receptor subtype, thus blocking the effect of Ang-II in the renin angiotensin system (RAS) cascade. Aratan is indicated for the treatment of hypertension.

Other names for this medication:
Angilock, Arapres, Araten, Cozzar, Eklips, Faxiven, Fensartan, Hypozar, Lepitrin, Losap, Losapot, Losargamma, Losartil, Losavik, Lostad, Lotim, Lozatan, Myotan, Niten, Normatens, Psycholanz, Rasertan, Sarve, Satoren, Sortal, Temisartan, Tensaar, Zartan

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Also known as: Losartan


Aratan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Aratan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Aratan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Aratan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Aratan 25 mg, Aratan 50 mg, and Aratan 100 mg may also contain carnauba wax.


Take Aratan tablets orally with or without food. Do not crush or chew it. Take Aratan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Aratan suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Aratan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Aratan. Correct volume or salt depletion prior to administration of Aratan.

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Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis. Under these conditions, endogenous reticulocyte mRNA is not inhibited. Application of an Active Modules algorithm to transcriptomic data identified key metabolic reactions and pathways altered in response to nitrogen stress, which are central to survival under nitrogen limiting environments. Using advanced imaging techniques, we show that cardiovascular and endocrine physiology, reflective of energy utilisation during acute stress, and energy storage (fat) differ between the sexes when they are exposed to chronic stress. A change in these operating parameters can cause one phenomena to become dominant over another, thus changing the particle or fluid behavior.

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A microtubule organizing centre (MTOC) is responsible for the production of the sperm flagellum in Matsucoccus feytaudi (Hemiptera: Coccoidea). Prediction of deterioration of mild cognitive impairment with CT and SPECT. Our models for pre-monsoon, post-monsoon, and overall periods of analysis find that since implementation of the 2009 act, groundwater tables have improved significantly. Penetration of Streptococcus sobrinus and Streptococcus sanguinis into dental enamel. The OIT for APTT determination was 15 to 30 sec in guinea pigs, rats and mice and 5 to 10 minutes in dogs and rabbits. The prudent healthcare profession will explore the origin of the condition to provide optimal comprehensive care to the infant and family. Polydioxanone is as effective as chromic gut suture material in inducing abomasal adhesion formation in our sheep model. Here, we review our current understanding of cellular and molecular mechanisms of CF synapse elimination in the developing cerebellum.

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IGF-1 at 500 ng/ml was best at overcoming detrimental effects associated with IL-1alpha in in vitro explants. Treatment with bevacizumab, a neutralizing antibody against VEGF, suppressed human pancreatic cancer growth in nude mice. The lesion treated is characterized by both computed axial tomography and histology, while the postsurgical bony contour also is revealed by CT. The present study findings suggest that compensatory hypertrophy of the middle turbinate is not affected by septoplasty, even after one year. Experimental findings suggest a high selective quenching of initial fluorescence intensity in the presence of nitroaromatic compounds. Two different assays were performed to evaluate the antibacterial potential of the honey samples: agar-well diffusion and broth macrodilution. PROTOCOLS FOR THE REMOVAL OF BACTERIA FROM FRESHWATER BENTHIC DIATOM CULTURES(1). Although the role of pteridines remains obscure, it appears that the parameters 2. Associations between disability severity and Pap smear use were inconsistent across the publications.

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Although fuel poverty is becoming increasingly researched, there is very limited information currently available on the experiences of and effects on children living in fuel poverty. Prospective observational study is to analyse the clinico-pathological aspects of NE carcinomas of the breast undergone surgical resection compared to breast carcinomas with a minor neuroendocrine component and to conventional invasive ductal or lobular cancers. Further large-scale studies with different ethnicities are needed to verify our findings. The data suggest that lymphocytes specifically sensitized to the proteolipid may be involved in the pathogenesis of the demyelination in chronic EAE. Participation at school as experienced by teenagers with physical disabilities. Rats were given diosmin with 3 doses as 225, 325, 425 mg x kg(-1). Antiphospholipid syndrome correction in pregnant and parturient women by the combined methods therapy. Felodipine, a new vasodilating drug: blood pressure, cardiac, renal, and humoral effects in hypertensive patients. Provoked vestibulodynia (PVD) is the most frequent subtype of vulvodynia. Next, we investigated the antiviral activity of the GBP nanoemulsion on influenza A H3N2 and hepatitis B virus in vitro by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide) method.

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are described from specimens collected from the skin of 2 blacktip sharks Carcharhinus limbatus, captured in the northern Gulf of Mexico. Retrospective investigation of seasonal factors influencing intraocular pressure in glaucoma patients. Further investigations for the pathogenesis of each classification are expected. The study population included all Israeli adolescents who underwent medical evaluation by the Israeli Defense Force, between the years 2005 and 2013. The patients were successfully treated by alcohol and epinephrine injection. Two-dimensional ultrasonic tissue characterization: backscatter power, endocardial wall motion, and their phase relationship for normal, ischemic, and infarcted myocardium. Comparative studies of similar populations from diet-induced hypercholesterolemic rabbits suggested an enhanced endothelial permeability as observed by an increase in cytoplasmic vesicles containing RR or Con A and by their intercellular passage into the subendothelium. CCK-8 (10(-8) M) only produces a trend for a small increase in the Bmax values of these receptors. However, these medications are not associated with significant clinical benefit in HFpEF. This will be valuable for the diagnosis of hepatic tumors, and it opens up new prospects for diagnostic imaging.

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The delivery of many drugs to the central nervous system (CNS) is limited due to the restrictive nature of the blood-brain barrier (BBB). Economic evaluation has been under-utilized in studies of skill mix. Detection of circulating tumor cells in carcinoma patients by a novel epidermal growth factor receptor reverse transcription-PCR assay. A high-resolution, continuous seawater calcium isotope ratio curve from marine (pelagic) barite reveals distinct features in the evolution of the seawater calcium isotopic ratio suggesting changes in seawater calcium concentrations. Capsaicin (125 mg) treatment led to almost total disappearance of SP-I fibers from all areas examined in both short- and long-term animals. Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Multivariate analysis of variance was conducted to detect differences between genders and intervertebral levels in each mode of loading. A short introduction is given about lipid polymorphism and phase behavior.

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Evaluation of three commercially available kits for serological diagnosis of dengue haemorrhagic fever. Serum analyses were made of some parameters often studied during undernutrition. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. In 2012, all 40 of the patients were matched with the Swedish Knee Arthroplasty Register (SKAR) and their medical records were reviewed to evaluate the long-term need for major knee surgery. The reduced joint association modeling results suggest that unique combinations of biomarkers with their related measure of association can be used to produce more accurate cumulative risk estimates for each CVD.

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We have designed generic data schema that can be used to develop paper or electronic based data collection forms depending on the availability of resources. Effects of low-molecular-weight fractions (LMWF) from milk, egg yolk, and seminal plasma on freezability of bovine spermatozoa. Patients as a mirror to reflect nursing practice: an advice from a head nurse. Retrospective chart review of patients treated for head and neck cancer from 1989 to 1993. The results encourage nurses to play a more active role in learning by assessing whether the information the caregivers are receiving is understood well enough to meet their learning needs. Sacrococcygeal teratoma, an enterogenous cyst, a polyp, a prolapse or other perineal tumors were all proposed as possible entities. The study was conducted in four pharmacy practice settings: independent and chain community pharmacies as well as private and public hospital pharmacies. Data on location of general practitioners, population size and crude mortality by statistical division (SD) were obtained from the Australian Bureau of Statistics. In accordance with our hypothesis, capsazepine produced anxiolytic-like effects both in the EPM and in the Vogel test.

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When selecting genes with controlling the same FDR level, our methods have on average a significantly lower false discovery rate in exchange for a minor reduction in the power. The vasotec 10 mg side effects study of antigenic variation of the Sabin type 1 vaccine virus during replication in human intestine showed that the VS neutralization epitope may be lost and even replaced by the VW epitopes of the parental Mahoney virus. However, the results of this study have shown some evidence regarding endogenous origin of involved superantigens in patients with rheumatoid arthritis. Immunotoxicological evaluation of toluene exposure via drinking water in mice. The hydrogen-bonding patterns of 3-phenylpropylammonium benzoate and 3-phenylpropylammonium 3-iodobenzoate: generation of chiral crystals from achiral molecules.

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Meticulous attention to detail allows any nodule in the chest to successfully undergo biopsy. Unusual association: Dandy-Walker-like malformation in the Rubinstein-Taybi syndrome. A new nondepolarizing, normokalemic adenosine-lidocaine arrest solution in Krebs-Henseleit buffer with 10-mmol/L glucose was versatile at both 4 degrees C and 28 degrees C to 30 degrees C relative to Celsior, and the addition of 1-mmol/L pyruvate significantly improved cardiac output at warmer arrest temperatures. Melflufen is currently being evaluated in a clinical phase I/II trial in relapsed or relapsed and refractory multiple myeloma. The distance between TVT trocar and pubic vessels, the bladder, external iliac vessels and obturator vessels were 0.6, 0.6, 4.2 and 4.3 cm, respectively. In our institution, trained student interns in the DUDSM program perform the necessary daily functions, such as patient screening, that are instrumental in maintaining the SOP.

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Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex. The present study aimed to assess the presence of the main types of microorganisms involved in the aetiopathogenesis of periodontal disease: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia and Prevotella intermedia in different samples collected from the oral cavity of 90 patients diagnosed with periodontitis. This central tenet of the discipline has been supported by four critical columns of knowledge, each of which has amplified over the passage of time. Whole-brain-averaged CBF was significantly decreased in the AN-WR group compared with the AN-C group, consistent with the PC-MRI results. This suggests that calcium dysregulation may be associated with the pathogenesis of FSP. Total or near total suppression of tumor growth was observed in mice receiving both treatments. Thus, this data does not support the hypothesis myringotomy, revealed a similar prevalence of bifid uvula.

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Results demonstrated that the orthogonal video-based tracking system was able to differentiate laparoscopic experience between experts and trainees surgeons. Hemagglutination-inhibition, virus neutralization, and enzyme-linked immunosorbent assay antibody production was also evaluated for comparative purposes. Immunochemical characterization of Klebsiella antigens which specifically modify an HLA-B27-associated cell-surface component. Availabilty: Cake is open-source and is available from Readministration of acebutolol after the ANA returned to negative resulted in a significant rise in ANA titer in two patients tested. Life stress and clinically elevated MMPI scales: gender differences in the xanax alcohol moderating influence of coping.

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In six patients with glycogen storage disease Ib the ratio of isoforms in the Pi type MM was 3.6:5.5:1.9 suggesting a shift from the biantennary to triantennary oligosaccharide side chains. Identification of drugs by principal components analysis of standardized TLC data in four eluent systems and of retention indices on SE 30. Application of resveratrol-synthesis-promoting bacterium, Bacillus cereus calcitriol drug strain NRKT, reduced the incidence of grape ripe rot disease caused by Colletotrichum gloeosporioides in a vineyard. This paper reviewed current approaches by sporting organizations to mental health promotion, prevention and early intervention by searching peak body websites, as well as the wider Internet. Ultrastructural observations of organelle accumulation in the equine recurrent laryngeal nerve. The Greek version of the general Nordic questionnaire for the analysis of musculoskeletal disorders (NMQ) was used for data collection. A two-stage neural network based technique for protein secondary structure prediction. Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. Possible correlation between exposure to AIDS risk factors, clinical presentation in AIDS, and subsequent prognosis.

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Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model. The putative ultraviolet (u.v.) carcinogenesis of cutaneous melanoma bears sufficient inconsistencies as to seriously challenge this theory. Many of the interventions were straightforward and could be adopted easily elsewhere. Split-dosed fetuses displayed less neurobehavioural suppression from trough to peak maternal methadone levels as compared with single-dosed fetuses. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. Testosterone versus clobetasol for maintenance of vulvar lichen sclerosus associated with variable degrees of squamous cell hyperplasia. Research over the past two decades broadly supports the claim that mindfulness meditation - practiced widely for the reduction of stress and promotion of health - exerts beneficial effects on physical and mental health, and cognitive performance. Thus, our results point unambiguously toward a stepwise mechanism involving the formation of a biradical intermediate on a singlet excited state.

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