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Aratan (Losartan)
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Aratan

Aratan and associated names, 12,5 mg, 25mg, 50 mg, 100 mg, film-coated tablets is an orally active angiotensin II (Ang- II) receptor antagonist, Aratan, acting on the AT1 receptor subtype, thus blocking the effect of Ang-II in the renin angiotensin system (RAS) cascade. Aratan is indicated for the treatment of hypertension.

Other names for this medication:
Angilock, Arapres, Araten, Cozzar, Eklips, Faxiven, Fensartan, Hypozar, Lepitrin, Losap, Losapot, Losargamma, Losartil, Losavik, Lostad, Lotim, Lozatan, Myotan, Niten, Normatens, Psycholanz, Rasertan, Sarve, Satoren, Sortal, Temisartan, Tensaar, Zartan

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Also known as: Losartan

Description

Aratan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Aratan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Aratan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Aratan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Aratan 25 mg, Aratan 50 mg, and Aratan 100 mg may also contain carnauba wax.

Dosage

Take Aratan tablets orally with or without food. Do not crush or chew it. Take Aratan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Aratan suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Aratan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Aratan. Correct volume or salt depletion prior to administration of Aratan.

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Although fuel poverty is becoming increasingly researched, there is very limited information currently available on the experiences of and effects on children living in fuel poverty. Prospective observational study is to analyse the clinico-pathological aspects of NE carcinomas of the breast undergone surgical resection compared to breast carcinomas with a minor neuroendocrine component and to conventional invasive ductal or lobular cancers. Further large-scale studies with different ethnicities are needed to verify our findings. The data suggest that lymphocytes specifically sensitized to the proteolipid may be involved in the pathogenesis of the demyelination in chronic EAE. Participation at school as experienced by teenagers with physical disabilities. Rats were given diosmin with 3 doses as 225, 325, 425 mg x kg(-1). Antiphospholipid syndrome correction in pregnant and parturient women by the combined methods therapy. Felodipine, a new vasodilating drug: blood pressure, cardiac, renal, and humoral effects in hypertensive patients. Provoked vestibulodynia (PVD) is the most frequent subtype of vulvodynia. Next, we investigated the antiviral activity of the GBP nanoemulsion on influenza A H3N2 and hepatitis B virus in vitro by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide) method.

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are described from specimens collected from the skin of 2 blacktip sharks Carcharhinus limbatus, captured in the northern Gulf of Mexico. Retrospective investigation of seasonal factors influencing intraocular pressure in glaucoma patients. Further investigations for the pathogenesis of each classification are expected. The study population included all Israeli adolescents who underwent medical evaluation by the Israeli Defense Force, between the years 2005 and 2013. The patients were successfully treated by alcohol and epinephrine injection. Two-dimensional ultrasonic tissue characterization: backscatter power, endocardial wall motion, and their phase relationship for normal, ischemic, and infarcted myocardium. Comparative studies of similar populations from diet-induced hypercholesterolemic rabbits suggested an enhanced endothelial permeability as observed by an increase in cytoplasmic vesicles containing RR or Con A and by their intercellular passage into the subendothelium. CCK-8 (10(-8) M) only produces a trend for a small increase in the Bmax values of these receptors. However, these medications are not associated with significant clinical benefit in HFpEF. This will be valuable for the diagnosis of hepatic tumors, and it opens up new prospects for diagnostic imaging.

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The delivery of many drugs to the central nervous system (CNS) is limited due to the restrictive nature of the blood-brain barrier (BBB). Economic evaluation has been under-utilized in studies of skill mix. Detection of circulating tumor cells in carcinoma patients by a novel epidermal growth factor receptor reverse transcription-PCR assay. A high-resolution, continuous seawater calcium isotope ratio curve from marine (pelagic) barite reveals distinct features in the evolution of the seawater calcium isotopic ratio suggesting changes in seawater calcium concentrations. Capsaicin (125 mg) treatment led to almost total disappearance of SP-I fibers from all areas examined in both short- and long-term animals. Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Multivariate analysis of variance was conducted to detect differences between genders and intervertebral levels in each mode of loading. A short introduction is given about lipid polymorphism and phase behavior.

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Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex. The present study aimed to assess the presence of the main types of microorganisms involved in the aetiopathogenesis of periodontal disease: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia and Prevotella intermedia in different samples collected from the oral cavity of 90 patients diagnosed with periodontitis. This central tenet of the discipline has been supported by four critical columns of knowledge, each of which has amplified over the passage of time. Whole-brain-averaged CBF was significantly decreased in the AN-WR group compared with the AN-C group, consistent with the PC-MRI results. This suggests that calcium dysregulation may be associated with the pathogenesis of FSP. Total or near total suppression of tumor growth was observed in mice receiving both treatments. Thus, this data does not support the hypothesis myringotomy, revealed a similar prevalence of bifid uvula.

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In six patients with glycogen storage disease Ib the ratio of isoforms in the Pi type MM was 3.6:5.5:1.9 suggesting a shift from the biantennary to triantennary oligosaccharide side chains. Identification of drugs by principal components analysis of standardized TLC data in four eluent systems and of retention indices on SE 30. Application of resveratrol-synthesis-promoting bacterium, Bacillus cereus calcitriol drug strain NRKT, reduced the incidence of grape ripe rot disease caused by Colletotrichum gloeosporioides in a vineyard. This paper reviewed current approaches by sporting organizations to mental health promotion, prevention and early intervention by searching peak body websites, as well as the wider Internet. Ultrastructural observations of organelle accumulation in the equine recurrent laryngeal nerve. The Greek version of the general Nordic questionnaire for the analysis of musculoskeletal disorders (NMQ) was used for data collection. A two-stage neural network based technique for protein secondary structure prediction. Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. Possible correlation between exposure to AIDS risk factors, clinical presentation in AIDS, and subsequent prognosis.

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