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Ativan (Lorazepam)

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Ativan, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Ativan tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

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Temovate, Arcoxia, Zyloprim, Terramycin, Sustiva, Propecia, Benicar

Also known as: Lorazepam


Ativan belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Ativan are categorized based on how fast they work. Ativan is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.


When given intramuscularly, Ativan Injection, undiluted, should be injected deep in the muscle mass.

Injectable Ativan can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Ativan Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Ativan Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.


In cases of a suspected Ativan overdose, it is important to establish whether the patient is a regular user of Ativan or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Ativan is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Ativan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Ativan if you have narrow-angle glaucoma or myasthenia gravis, or if you are allergic to Valium or a similar medicine.

Do not use Ativan if you are pregnant. This medicine can cause birth defects or life-threatening withdrawal symptoms in a newborn.

Ativan may be habit-forming and should be used only by the person it was prescribed for. Misuse of habit-forming medicine can cause addiction, overdose, or death. Ativan should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Do not drink alcohol while taking Ativan. Ativan can increase the effects of alcohol.

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Effect of Two Macrocephala Flavored Powder supplementation on intestinal morphology and intestinal microbiota in weaning pigs. Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population. Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol. The increased singing began after the new female had started to sing solo female great calls. Indeed, diseases such as cancer can occur in the offspring due to epigenetically-inherited gene expression profiles induced by stress experienced by the parent. The suborbicularis oculi fat was then suspended in the same manner. The role of the nurse in the education of diabetics in a hospital environment. To validate the assay for screening and reliable early detection of HIV-1 infection in Asia.

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Prenatal stress exacerbates the impact of an aversive procedure on the corticosterone response to stress in female rats. All entities in all knowledge-bases in the repository are linked to public database entries as well as to a newly created public wiki which provides a discussion forum. These proteins are the translation products of parasitism genes and are secreted molecular tools that allow cyst nematodes to infect plants. Water adsorption on the stoichiometric (001) and (010) surfaces of hydroxyapatite: a periodic B3LYP study. Previous work validates the use of virtual patients (VP) to teach and assess content items related to history-taking and basic communication skills. Isolation of the antigen-active components from leptospiral serovar-specific lipopolysaccharide antigen by mild ultram tabs acid hydrolysis. Qualitative and quantitative evaluations of the reaction were performed. Several studies have addressed the effects of structural modifications of alpha-crystallin on chaperone activity, but little is known about the solubilities of the various beta-crystallins or the effects of post-translational modifications.

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Analyses controlled for socioeconomic status, age, and recruitment location. To examine the frequency and types of complications in patients with stroke. Despite many years of state-sponsored efforts to eradicate the disease from cattle through testing and slaughter, bovine tuberculosis (bTB) is still regarded as the most important and complex of animal health challenges facing the British livestock agricultural industry. If increased serum proteolytic activity increases the chance of rupture of an AAA, then the release of neutrophil elastase may provide a mechanism whereby urispas 200 mg tablet asymptomatic AAAs rupture after unrelated elective surgery. The price of PPIs highly influenced the robustness of the results. Using this RIA, intact NT response to a mixed meal has been assessed in 10 healthy humans.

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RRAOF was induced by tipping the maxillary first molar mesially for 9 days. MALDI-TOF-MS was performed using bacteria obtained from one isolated colony. Activation of ERK or p38 is required for both TGF-beta-induced EMT and cell migration, whereas PI3K/Akt is necessary only for TGF-beta-promoted cell migration but not for EMT. Actinic keratoses, actinic field change and associations with squamous cell carcinoma in renal transplant recipients in Manchester, UK. Neuropsychological testing has been advocated lipitor cost per day as an important tool of proper post-concussion management.

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We highlight the importance of suspecting unusual pathology in patients with NSA and no trauma history. Both the fissions of spinless and spin carriers are ultrafast dynamical processes. The cytotoxic T cell response generated by subsequent in vitro stimulation with AED-self was found to contain H-2K and H-2D region-specific components. Control animals received either normal rabbit serum (NRS) or no serum. According to electrospray ionization mass spectrometry and sonochemiluminescence emission spectra, SCL emission could be ascribed to the formation of N ramipril 10 mg cost uk -methylacridone with a different mechanism from that in both the chemiluminescence and electrochemiluminescence reaction of acridinium ester. These volumes were compared to the volume measurements obtained from dissection of the tissue and phantom gels. Drug release profiles seemed to conform to the mechanism involving the osmotically driven release and formation of channels in the film caused by dissolution of pectin. Vitamin E provided significant protection against the development of functional and histological features characteristic of DN to Hp 2-2 DM but not to Hp 1-1 DM mice.

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Mediating mechanisms of a military Web-based alcohol intervention. Furthermore, this study suggests a strategy for the efficient design of ET receptor antagonists with targeted inhibition of ET-1 signalling in vascular endothelial cells. Black-White differences in hysterectomy prevalence: the CARDIA study. Investigation of zoonotically acquired Campylobacter jejuni enteritis with serotyping and restriction endonuclease DNA analysis. Presence of hernia sac in prediction of postoperative outcome in congenital diaphragmatic hernia. Getting a clue to the hydrolytic activation of white phosphorus: the generation and stabilization of P(OH)2PHPHPH(OH) at ruthenium centers. Although recent studies suggest that interferons can increase the number of IgG Fc receptor (FcR gamma) sites on mouse macrophages, direct assessment of similar effects on human mononuclear phagocytes is lacking. In the early stages of atherosclerotic lesion development, cholesterol is mostly present as esterified cholesterol stored in macrophage cytoplasmic lipid droplets.

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Impact of exercise stress testing on diagnostic gene expression in patients with obstructive and nonobstructive coronary artery disease. Immunological identity of brucella native hapten, polysaccharide B, and yersinia enterocolitica serotype 9 native hapten. The results show that it is possible to increase, and stabilize, the yield of a grassland crop and reduce invasion by unsown species by increasing its species diversity. With regard to the occurrence of (18)F-FET-negative glioma, we investigated the value of (18)F-FET PET monitoring of primarily (18)F-FET-negative gliomas concerning the detection of progression and malignant transformation. The antibacterial activities of the synthetic peptides based on the Hlgut-defensin and Hlsal-defensin sequences were tested against a variety of Gram-positive and Gram-negative bacteria.

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