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Axedol (Tramadol)

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Axedol is used to help relieve moderate to moderately severe pain. Axedol is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Armadol, Arodol, Cadol, Didol, Domadol, Eltram, Esgiypyrin, Ivydol, Kamadol, Kevtram, Mandol, Moludol, Nictram, Nosdol, Novadol, Ondol, Orchidol, Painadol, Paintrol, Ramcet, Rimol, Rybix, Sedate, Servodol, Supridol, Takol, Taxidol, Tragesic, Tramacip, Tramaflam, Tramagesic, Tramak, Tramed, Tramol, Tramot, Tranzat, Trasic, Tridol, Trydol, Urogendo

Similar Products:
Coreg, Amaryl, Imitrex, Persantine, Celebrex, Vermox, Elocon, Antabuse

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Axedol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Axedol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Axedol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 2 and 30 degrees C (36 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Axedol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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In CHC and CHB, APRI had lower performances than FIB-4, TE and FibroTest. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). The clinical course and pathological findings of 3 rare cases of androgen-producing ovarian tumors are presented. The SEER (Surveillance, Epidemiology, and End Results) data for the years 1975-1998 show that children with non-Hodgkin lymphoma (NHL) have a better treatment outcome than do adults. Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth.

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The inherent contrast generated by water properties is exploited in MRM by choosing suitable pulse sequences, or proton stains. The effect of prolonged light deprivation on ultrastructure, pigment composition and functions of photosynthetic apparatus of the resurrection plant Haberlea rhodopensis Friv. The objective was to investigate whether circulating levels of the Wnt antagonist sclerostin associate with progression of VC. The neutrophil-lymphocyte ratio (NLR) is a new prognostic predictor for patients with liver cancer. Digital Photograph Security: What Plastic Surgeons Need to Know.

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As a result of this sensitized state, behavioral testing procedures are thought to cause excess serotonergic activity in brain regions that control these behaviors. The Pax-6 gene encodes a transcription factor essential for the development of eyes and other sensory organs in species ranging from planaria to mice. Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design. From observational studies effects of SLIT are suggested to persist after discontinuation. Contrast echocardiography clarifies uninterpretable wall motion in intensive care unit patients. Chorea, once considered a benign self-limited disease, is now felt to require more aggressive treatment, in particular with sedatives. In contrast, ecosystem respiration responses to OTCs differed between the upper and the lower slopes, implying that the response of vegetation to climate change may override microbial responses.

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Electrokymographic study in the diagnosis of cancer and suppurative processes in the lung. A nation-wide program is here recommended to include Federal assistance to the states not to exceed fifty percent of the cost, with the states effecting an immediate stock-taking of baby saving machinery, together with the pooling of resources. To determine the molecular pathways influenced by 1 alpha, 25-dihydroxyvitamin D3 (1,25D) in breast epithelial cells we isolated RNA from normal human breast and cancer tissues treated with 1,25D in an ex vivo explant system. Metabolomic signatures of mitochondrial stress and altered energy metabolism indicated alterations in nucleotide, Krebs cycle, energy transfer, carbohydrate, neurotransmitter, and amino acid metabolic pathways. Field potentials were recorded from intratectal electrodes in response to a stroboscope flash to the contralateral eye. This case is being presented because of its huge dimensions, rarity of the site and mixed histological pattern. Overall, both the NA and relational security of men and women predicted stability. The data were used to examine the boundary layer structure during this severe air pollution period. Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts.

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The Risk of Depressive Disorder Among Contacts of Tuberculosis Patients in a TB-endemic Area: A Population-based Cohort Study. We categorized the merits and limitations of the SWD to distinct phases in the design and conduct of such studies, highlighting that their impact may vary depending on the context of the study or that benefits may be offset by drawbacks across study phases. This study set out to evaluate magnetic resonance imaging (MRI) and measurement of optic disc size as diagnostic tools for confirming the diagnosis of optic nerve hypoplasia (ONH) in children with impaired growth. By virtue of its function, the receptor is accessible to the host immune system and displays substantial sequence variation. Study on pottical type, palmar and plantar digital formulae, hand clasping, arm folding, handedness, leg folding and stride type in the Daur population, China. Here we show, in live Escherichia coli cells, that, upon expression of a Tat substrate protein, fluorescently labeled TatE-GFP relocates from a rather uniform distribution in the plasma membrane into a number of discrete clusters.

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The purpose of this report was to update the results of the Maternal Phenylketonuria Collaborative Study, which was established to assess the efficacy of a phenylalanine-restricted diet in preventing morbidity among the offspring of women with hyperphenylalaninemia. CAD/CAM composites), a hybrid material (VITA Enamic), a leucite (IPS Empress CAD) and a lithium disilicate glass-ceramic (IPS e.max CAD). Posterolateral rotatory instability (PLRI) of the elbow is a chronic condition that results from lateral collateral ligament complex injury and presents with pain, clicking, and subluxation within the flexion and extension arcs of elbow motion. CBX also greatly improved micturition pattern, as manifested by the apparently decreased micturition frequency and increased micturition volume. Although initiation of DNA replication is considered to be highly coordinated through multiple protein-DNA and protein-protein interactions, it is poorly understood how particular locations within the eukaryotic chromosome are selected as origins of DNA replication.

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Pulldown assays showed that each C/EBPepsilon isoform interacted directly with the DNA binding domain of the c-myb protein. Decellularization of porcine articular cartilage explants and their subsequent repopulation with human chondroprogenitor cells. Full-thickness defects of cartilage were created in the trochlear groove of twenty-five adult New Zealand White rabbits. The information obtained is useful for patients to understand their musculoskeletal health, governmental agencies allocating healthcare resources, provision of management guidelines, and as a link to other data sets, such as hospital episodes statistics. The patient presented with heavy vaginal bleeding following vaginal delivery complicated by retained products of conception.

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Influence of the estrous cycle on the nucleic acid content of the rat anterior pituitary. Member selection was based on profession, practice setting, and location, and zithromax antibiotic ingredients members disclosed any actual or potential conflicts of interest. Nutrition education designed for children was more effective in the short than the medium term. The immune system plays a critical role in cancer progression and overall survival. Emerging evidence indicates that boron (B) plays a role in bone formation and maintenance.

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