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Azithrus (Azithromycin)
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Azithrus

Azithrus belongs to a group of Macrolide Antibiotics useful for treating numerous infections caused by bacteria like middle ear infections, traveler's diarrhea. Along with other medications, it is sometimes used for malaria. It is also used to treat a number of intestinal infections and sexually transmitted infections including gonorrhea and chlamydia. Administration of the medicine takes place either by mouth or intravenously with doses once per day.

Other names for this medication:
Arzomicin, Atizor, Azalid, Azicid, Azicin, Azifast, Azigram, Azimac, Azimex, Azimit, Azinix, Azirox, Azithromax, Azithromycinum, Azithrox, Azitrim, Azycyna, Azyth, Disithrom, Goldamycin, Goxil, Magnabiotic, Medimacrol, Mezatrin, Momicine, Naxocina, Opeazitro, Oranex, Phagocin, Rarpezit, Respazit, Ricilina, Thiza, Triamid, Trozocina, Unizitro, Zetamax, Zifin, Zimax, Zithrogen, Zithrox, Zitrocin, Zitrofar

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Also known as: Azithromycin

Description

Azithrus (Azithrus tablets and Azithrus for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Azithrus has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithrus is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Azithrus, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Azithrus is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Azithrus for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Dosage of Azithrus is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not store the liquid longer than 10 days.

Side effects

The most common side effects associated with Azithrus are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Azithrus if you are allergic to azithromycin and other macrolides. Do not take Azithrus at the same time as taking antacids containing magnesium or aluminum. Exercise caution with Azithrus if you are pregnant or are a nursing mother. If you have liver or kidney disease, Long QT syndrome or heart rhythm problems, consult your doctor before taking Azithrus. Exercise caution if you are also taking cyclosporine (Neoral, Sandimmune), anticoagulants ('blood thinners') such as warfarin (Coumadin), terfenadine (Seldane), digoxin (Lanoxin), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar), phenytoin (Dilantin), medications that suppress your immune system, nelfinavir (Viracept). Exercise caution with Azithrus usage if you are allergic to erythromycin (E.E.S., E-Mycin, Erythrocin), dirithromycin (Dynabac), clarithromycin (Biaxin) or azithromycin. Avoid excessive exposure to sunlight as Azithrus makes skin sensitive to sunlight. Take care to protect skin from the sun. It can be dangerous to stop taking Azithrus suddenly.

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