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Benforce (Metformin)

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Benforce also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Benforce is used alone or with other medications, including insulin, to treat type 2 diabetes. Benforce is in a class of drugs called biguanides.

Other names for this medication:
Diamin, Diavista, Dibimet, Dipride, Etformin, Eumet, Exermet, Formin, Getmet, Glimet, Glimkap, Glitenly, Glucoact, Gluformin, Glycimex, Glyciphage, Glycirest, Glycomet, Glycurub, Glynase, Glyrep, Medformin, Mefomin, Metalok, Metclam, Metformin, Metica, Metlife, Metsafe, Metsar, Monomet, Nilconorm, Obimet, Osimet, Ozomet, Reglide, Riomet, Roglin, Rosinorm, Rosizon, Sumet, Triglucored, Vogic, Vogipax, Voglinorm, Volabay, Zetfor, Zomelis

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Also known as: Metformin


{name} (metformin) is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is sometimes used together with insulin or other medications, but metformin is not for treating type 1 diabetes.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take MetFORMIN (Eqv-Benforce XR) with a meal, unless your doctor tells you otherwise. Some forms of MetFORMIN (Eqv-Benforce XR) are taken only once daily with the evening meal. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

MetFORMIN (Eqv-Benforce XR) is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Your doctor may have you take extra vitamin B12 while you are taking MetFORMIN (Eqv-Benforce XR). Take only the amount of vitamin B12 that your doctor has prescribed.

Detailed Metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Benforce are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Benforce if you are allergic to metformin, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Benforce. Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using Benforce if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Tell your doctor if you become pregnant while taking Benforce.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

Benforce should not be given to a child younger than 10 years old. Benforce XR is not approved for use by anyone younger than 18 years old.

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Human coronavirus NL63 was isolated and identified by RT-PCR and sequencing, and its replication in a fresh batch of RPTEC and another type of primary human kidney cells was confirmed. The results of our present study demonstrated that the sulfation of DHEA by DHEA-ST occurs in the gastric glands. Selective serotonin reuptake inhibitor use by patients with acute coronary syndromes. 18F sodium fluoride PET/CT detects osseous metastases from breast cancer missed on FDG PET/CT with marrow rebound. Infantile haemangiomas of the head and neck: current concepts in management. ATM/ATMIN complex disruption by IR was attenuated in cells with impaired NBS1 function, suggesting competition of NBS1 and ATMIN for ATM binding. After 6 weeks, enchondral bone had formed in the bone graft layer and on the periosteal anterior and superior rim in the OP-1 group only. Variation in reported experience of involvement in cancer treatment decision making: evidence from the National Cancer Patient Experience Survey. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Interactions Among Different Devices and Electrical Stimulus on the Electroejaculation of Captive Agoutis (Dasyprocta leporina).

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Fifty independent isolates of H pylori were obtained by endoscopy-assisted gastric biopsy from patients attending the University of Chile Clinical Hospital, that previously had not been treated with an eradication regime against this bacterium. Red wine polyphenolic compounds inhibit tracheal smooth muscle contraction during allergen-induced hyperreactivity of the airways. This approach could be adapted to high-throughput techniques for determination of the mammalian neurite outgrowth gene repertoire. CE-MRI is more sensitive than unenhanced MRI for detecting intravertebral clefts in patents with benign compression fractures less than 3 months old. Identifying ecologically valid, real-world opportunities to extend laboratory findings is a valuable means of advancing this field. Therefore, research is urgently needed to establish treatment for patients with chronic kidney disease. The accelerated dynamic hyperinflation may contribute to increased airway and systemic inflammation in COPD patients. All types of NPs activated the complement system primarily via the alternative pathway rather than the lectin pathway. He was treated with intravenous ganciclovir, with no further hematochezia.

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On a molar basis, SIH was more protective against hydrogen peroxide than other iron chelators and an antioxidant. A complication does not necessarily represent a breech in the standard of care that constitutes medical negligence or medical malpractice. In order to identify Peucedani Radix, Peucedani Decursivi Radix and their adulterants, the internal transcribed spacer 2 (ITS2) regions of Peucedani Radix, Peucedani Decursivi Radix and their adulterants were amplified and bidirectionally sequenced based on the Principles for Molecular Identification of Traditional Chinese Materia Medica Using DNA Barcoding, which has been promulgated by Chinese Pharmacopoeia Commission. Evaluation of spinal internal loads and lumbar curvature under holding static load at different trunk and knee positions. Monitoring defined populations longitudinally will allow assessment of the effectiveness of such national and local initiatives. The diversity of immunoglobulin (IG) and T cell receptor (TR) chains depends on several mechanisms: combinatorial diversity, which is a consequence of the number of V, D and J genes and the N-REGION diversity, which creates an extensive and clonal somatic diversity at the V-J and V-D-J junctions. We examined fibronectin for its fibrosis-inducing effect, comparing both presently available fibrin adhesive systems, because one contained up to 5 times more fibronectin per milliliter than the other. Normal thallium uptake on single photon emission computed tomographic scintigraphy early in the hospital course predicted myocardial viability in the region of the aneurysm. Molecular chaperones in pathogen virulence: emerging new targets for therapy. For this purpose, we used DBA/2 mice, an inbred strain commonly used for the study of stress effects on psychostimulant sensitization.

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Dendritic cell commitment and function require orchestrated regulation of transcription. Home prothrombin time monitoring after the initiation of warfarin therapy. We investigated the possible effect of taurine supplement on prenatal and perinatal lead-induced synaptic plasticity deficit and determined developmental periods critical for the effect of taurine. In accordance with the histopathological features of BUs, our results suggest that bacterial production of mycolactone may limit both the initiation of primary immune responses and the recruitment of inflammatory cells to the infection site. It could be that, as a result of taurine administration, the catabolism of cholesterol to bile acid in the liver is accelerated, followed by a decrease of the hepatic cholesterol pool, resulting in a suppression of the synthesis and/or secretion of VLDL (beta-VLDL) in the liver. Interventions to reduce dependency in personal activities of daily living in community-dwelling adults who use homecare services: protocol for a systematic review. Child physical abuse risk moderates spontaneously inferred traits from ambiguous child behaviors. Patients seen in 80 consecutive office visits served as subjects. These improvements in secondary safety are not observed in the case of single-car crashes, very probably because of higher impact speeds. Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression.

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The aim of this study was to use microarray analysis of gene expression in metabolic tissues from a mouse model of pre-diabetes and T2D to further understand the metabolic abnormalities that may contribute to T2D. From May 2007 to November 2007, 47 patients suffering from chronic wounds of lower limbs were treated. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of GBC. The possible mechanism for these observations is proposed as follows: morphinone binds covalently to sulfhydryl group of opiate receptors, and inactivates irreversibly opiate binding sites, thus blocking the analgesic effect of morphine. Contrasting results have been published so far on the effectiveness of amifostine in correcting cytopenia in patients with myelodysplastic syndromes (MDS). Finally, we discuss prospects for the future development of broad spectrum prophylactic anticancer vaccines.

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We purified a factor from semi-synchronized early embryos that binds to an end-1 cis regulatory region critical for its endoderm-specific expression. Antilysin with a prolonged effect in dogs with experimental acute pancreatitis. Creating a healthy work environment to keep patients safe and staff engaged in the mission of the organization is perhaps one of the most important roles of hospital administrators and nursing leaders. To evaluate the magnetic properties of the spleen in chronically transfused, iron-overloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys. The compound Spermine was subsequently marketed as an injection that promised the effects observed by Brown-Sequard. Randomized controlled trials (RCTs) and cohort and preclinical studies identified in electronic databases were reviewed.

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The KBv200 cell xenograft model was established to investigate the effect of PEDLLA-FG020326 on reversing MDR in vivo. Determining whether hypoplasia of a coronary artery has caused or contributed to death is often complicated by an absence of histologic evidence of myocardial ischemia in the area of the heart supplied by the affected artery and also by the lack of data for assessing coronary artery size at autopsy. Results of conservative treatment of vesico-ureteral reflux in infants and young children. Hand-assisted laparoscopy is a minimally invasive technique with operating times and outcomes similar to those of conventional procedures. In the present investigation we examined the effects of PCP, and PCP-receptor agonist, ketamine, on dopamine (DA) release by measuring the levels of 3-methoxytyramine (3-MT), the only DA metabolite which is a reliable indicator of DA release in vivo. Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys. Cost-effectiveness of interferon-gamma release assay testing for the treatment of latent tuberculosis. We find that Wls expression is markedly increased in clinical breast tumors compared with adjacent noncancerous tissues. Do children with specific language impairment and autism spectrum disorders benefit from the presence of orthography when learning new spoken words?. Genetic characterisation of farmed rainbow trout in Norway: intra- and inter-strain variation reveals potential for identification of escapees.

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Bond strength of resin to acid-etched dentin studied by 13C NMR: interaction between N-methacryloyl-omega-amino acid primer and dentinal collagen. Phenotypic variability is substantial and includes both diffuse and segmental forms of left ventricular hypertrophy. Since DIF specifically induces the differentiation of prestalk cells, the anterior cells of the slug, it could be anticipated that DIF is localized in the prestalk region. Randomized studies are warranted to confirm for potential advantages of transradial approach versus the femoral approach in cardiac catheterization. The reduced DIG association of HAt- and NAt- is an intrinsic property of the glycoproteins, as similar reductions in DIG association were observed when the proteins were expressed from cDNA. Karyomegalic interstitial nephritis (KIN) is a chronic interstitial nephropathy characterized by tubulointerstitial nephritis and formation of enlarged nuclei in the kidneys and other tissues. A comprehensive review of the available literature will be presented. In this study, we determined the gene expression profiles of murine melan-a melanocytes treated with ASP or alphaMSH over a 4-day time course using genome-wide oligonucleotide microarrays.

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We have used this foundation to devise an applicable coil design method that starts with a set of realistic constraints and ends with the optimal coil pair geometries. The analysis of equations determining algorithms for DMLC IMRT delivery under a variable beam dose rate reveals a multitude of possible delivery strategies for a given intensity map and for any given target motion patterns. Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?. These compounds have been shown to be active at similar concentrations also against Staphylococcus epidermidis and both oxacillin-sensitive and resistant Staphylococcus aureus and Staphylococcus epidermidis. Patient discomfort with prolonged bedrest following femoral arterial puncture for cardiac catheterization is a significant nursing problem. Impact of acute respiratory failure on survival of COPD patients managed with long-term non-invasive ventilation and oxygen therapy.

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The main purpose of FNAC or CNB of breast lumps is to confirm cancer preoperatively and to avoid unnecessary surgery in specific benign conditions. The current study was designed to evaluate the hepatoprotective and genoprotective effects of powder seeds from guarana on CCl4-induced liver injury in rats. This transformation permits access to interesting substitution patterns of dihydropyrimidines which have found use as nucleotide exchange factor inhibitors. Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals. Specific immunotherapy with house dust mite allergens in an adult flagyl tablet crush with severe atopic dermatitis. Employment Status, Depression, Drinking, and Alcohol Use Disorder in Puerto Rico.

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Pathological stage and myometrial invasion are independent prognostic factors for late stage endometrial cancer. Hypoelectronic dimetallaheteroboranes of group 6 transition metals containing heavier chalcogen elements. For each patient, urticaria activity score was calculated and autologous serum skin test was done. Genetic screening for HFE hemochromatosis in 6,020 Danish men: penetrance of C282Y, H63D, and S65C variants. A highly selective two-photon fluorescent probe for the determination of mercury ions. The symptoms, TBUT, and fluorescein and rose bengal scores markedly improved after long-term dual treatment without any side effects for 6 months. However, there lexapro dosage range is a need to explore alternatives sources of LC-PUFA, especially those of microbial origin.

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Rescue ERCP and emergency application of small-caliber (4-5F, 4-cm, Geenen stent) pancreatic stents were successfully performed in all patients within 8-20 h after the initial ERCP. This case highlights the importance of an early and preferred treatment in the form of a controlled surgical intervention as compared to an endoscopic extraction for patients with impacted dentures with sharp hooks. Effects of metal binding on solubility and resistance of physiological prions depend on tissues and glycotypes. The objective of this study is to describe a sexually transmissible infection (STI) testing outreach program (the Testing Tent) at a gay community event. We searched the Cochrane Diabetes Group specialised register, The Cochrane Library, MEDLINE (January 1966 to December 1996), EMBASE (to December 1996), Cinahl (to December 1996), National Research Register (to December 1996), PsycLIT (to December 1996), HealthSTAR (to December 1996), CRIB (to December 1996), Dissertation Abstracts (to December 1996), and reference lists of articles. The A-V conduction times were recorded in basic condition and 30 minutes after administration of the drug. We introduce a novel, remotely powered and wirelessly controlled intraoral electrolarynx that addresses these issues. Sst2 may constitute a therapeutic target to lower hyperglucagonemia in type 2 diabetes.

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