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Bicofen (Roxithromycin)
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Bicofen

Bicofen is indicated for the treatment of the following mild to moderately severe infections in children caused by or likely to be caused by susceptible micro-organisms: acute pharyngitis, acute tonsillitis and impetigo.

Other names for this medication:
Acevor, Assoral, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Erybros, Infectoroxit, Klomicina, Ladlid, Macrosil, Makrodex, Monobac, Nirox, Overal, Pedilid, Ramivan, Remora, Rokilide, Roksimin, Roksolit, Rolexit, Rolicyn, Rossitrol, Rotramin, Roxacine

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Also known as: Roxithromycin

Description

Bicofen is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Bicofen is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Bicofen is available under several brandnames. Bicofen is not available in the United States. Bicofen is available in Australia, Israel and New Zealand. Bicofen has also been tested to possess antimalarial activity.

Bicofen prevents bacteria from growing, by interfering with their protein synthesis. Bicofen binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Bicofen has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Bicofen is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Bicofen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Bicofen if you are allergic to Generic Bicofen components. Try to be careful with Generic Bicofen if you're pregnant or you plan to have a baby, or you are a nursing mother. It can be dangerous to stop Generic Bicofen taking suddenly.

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Cancer is intrinsically complex, comprising both heterogeneous cellular compositions and microenvironmental cues. Participants were classified according to a combination of smoking status and BMI. To investigate co-occurrence and shared personality characteristics of problematic computer gaming, problematic gambling and substance use. Records of dog bite injuries reported to the Alaska Trauma Registry (ATR) were. Using simulated data, for which transmitter impairments are known exactly, the method is shown to be accurate and robust. Rhizobia isolated from fertilized field soil had higher growth rates in the presence of plant fertilizer compared to isolates from unfertilized field soil, indicating that plant fertilizer application favoured rhizobia isolates with higher abilities to utilize fertilizer for free-living growth. On the first day of hospitalization the patients performed a SCL-90-R test, and blood samples were taken for measuring liver enzymes, total bilirubin, unbound cortisol and lymphocyte populations.

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To Maintain Pediatric Competence, Walk With Our Patients and Families. Pathogenic role of NF-kappaB activation in tubulointerstitial inflammatory lesions in human lupus nephritis. Sleep loss and recovery after administration of drugs related to different arousal systems in rats. Antigen-specific tolerance of human alpha1-antitrypsin induced by helper-dependent adenovirus. The animals were exposed to methyl mercury either as a single dose i.p. We report that carboxyl-grafted SPIONs, magnetically concentrated in a biofilm, cause an approximately 8-fold higher percentage of dead staphylococci than does gentamicin for a gentamicin-resistant strain in a developing biofilm. For this purpose, a program for multistage designs was developed to calculate these performance indicators under various conditions of the number of samples, alleles of candidates, alleles remaining in the final stage, and genotypings. Our review targets 30 highly cited studies located through Google Scholar (as an interdisciplinary search engine) and published within a specific timeframe (2005-2010). For a time-to-event response, marginal structural Cox models are frequently used to deal with such confounding. Our results support the finding that FZ should be classified as a Schedule I drug (i.e., a drug similar to heavy narcotics).

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The effects of clipping on thoracic sympathetic nerve in rabbits: early and late histopathological findings. These results show that processing demands can pull the two fixated eyes in the same direction and that the response to this pull can differ for the right and left eye. Consecutive cases of ischemic stroke after cardiac catheterization were abstracted retrospectively and reviewed by clinicians at 7 major North American academic centers with acute stroke teams. This study indicated that TLE3 repressed CRC proliferation partly through inhibition of MAPK and AKT signaling pathways, suggesting the possibility of TLE3 as a biomarker for CRC prognosis. A 150-variable database was prospectively collected at time of ES, before discharge and again at 30 days in consecutive patients undergoing ES at 17 centers. First forum debate: telemetry is necessary for optimum mobile care in a rural setting. Thirty-seven patients undergoing FESS for CRS, with or without polyps (21 male, mean age 48.8).

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Increasing Dialysis Sodium Removal on Arterial Stiffness and Left Ventricular Hypertrophy in Hemodialysis Patients. The effect of dl-alpha-lipoic acid on lipid peroxidation and antioxidants status has been studied in the blood of young and aged rats. Host expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in normal colon tissue affects metastatic potential of colorectal cancer. Methods and results of local treatment of brain metastases in patients with breast cancer. Plans were compared using the coverage index (CI), the external volume index (EI), the dose homogeneity index (DHI), the overdose volume index (OI) and the conformal index (COIN). In shared decision making (SDM), the patient and the physician reach decisions in partnership.

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The uroplakin (UP) promoter is a powerful tool for bladder cancer gene therapy, but the role of UP protein in the bladder remains unknown. Patients with incident PAH were enrolled between December 2003 and April 2006 in six centers from the French Network on Pulmonary Hypertension and followed for 3 years.Venous blood samples were taken during right-sided heart catheterization, and analyses were centralized. The latter could be seen on optical coherence tomography scans before the treatment as an optically heterogeneous formation beneath the neurosensory epithelium. Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2. Ruthenium porphyrin compounds for photodynamic therapy of cancer.

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Impact of telomere length on survival in classic and variant hairy cell leukemia. 304 vessels (17 patients) were compared with DSA as the standard of reference. Elevation of serum levels of urokinase-type plasminogen activator and its receptor is associated with disease progression and prognosis in patients with prostate cancer. Bcl-2 was detected in the interlobular bile ducts and bile ductules, but not in the large and septal bile ducts in all cases examined. Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity-An Overview. However, recent studies using alternative designs to disentangle the effect of social and genetic confounders have suggested that confounding may account for the association.

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