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Bifosa (Alendronate)

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Bifosa is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause, or if you are taking corticosteroid medications (such as prednisone) for a long time.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Dulcolax, Aristocort, Thorazine, Depakote, Dramamine, Calan, Ovral, Vasotec, Naprosyn

Also known as: Alendronate


Generic Bifosa is a drug which helps to fight with postmenopausal osteoporosis, steroid-induced osteoporosis, Pagets disease of bone. Generic Bifosa is a medicine which belongs to the group of medicines called bisphosphonates. Bifosa is also known as Alendronic acid, Alendronate sodium, Ostofos. Generic Bifosa works by preventing bone breakdown and increasing bone density (thickness). Generic name of Generic Bifosa is Alendronate. Brand name of Generic Bifosa is Bifosa.


Take Bifosa exactly as prescribed by your doctor. Bifosa is taken either once daily or once per week. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Bifosa first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take this medicine only once per week, take it on the same day each week and always first thing in the morning.

Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an Bifosa tablet. Swallow the tablet whole.

For at least 30 minutes after taking Bifosa:

Do not lie down or recline. Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Bifosa. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate.

Bifosa is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Your doctor will determine how long to treat you with this medicine. Bifosa is often given for only 3 to 5 years.

Detailed Bifosa dosage information


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bifosa are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Bifosa Plus D if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

Do not take a Bifosa Plus D tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking Bifosa Plus D.

To make sure Bifosa Plus D is safe for you, tell your doctor if you have:

low blood calcium (hypocalcemia); a cancer such as sarcoidosis, leukemia, lymphoma; a vitamin D deficiency; kidney disease; or an ulcer in your stomach or esophagus.

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Bifosa Plus D, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Bifosa Plus D will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether alendronate and cholecalciferol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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Increasing amounts of evidence indicates that miR-125b may serve as a diagnostic biomarker of certain kinds of cancers. pylori in a cohort of patients with CF and its cross-reactivity with Pseudomonas antibodies were investigated. Depending upon the protocol, acute fatiguing weakness develops 2 - 14 days after the start of autoantibody injections (passive transfer) or might require repeated immunizations over several weeks (active models). The decrease of this critical T cell population in middle-aged mice was not a result of inherent T cell deficiencies, but was revealed to be T cell extrinsic. Several studies have demonstrated that mild hypothermia exhibits a neuroprotective role and it can inhibit endothelial cell apoptosis following ischemia/reperfusion injury by decreasing caspase-3 expression. We argue that schism was triggered by political-regulatory influences rather than economic or other social institutional forces, and predict that other decentralized public health care systems may follow a similar path.


Cytochrome P-450 mediated metabolism in active murine systemic lupus erythematosus. The interaction of polyphenols with phosphatidylcholine was investigated by HPLC with an immobilized artificial membrane (IAM) column. Effects of social stress on behavior and corpus luteum in female golden hamsters (Mesocricetus auratus). The radial artery is a suitable, beneficial route for coronary procedures and is considered a good alternative to transfemoral access. This allows sensing the presence of clinically relevant concentrations of lysozyme in undiluted serum samples. cholerae, ranging from 3.4 x10(7) to 10(3) and 10(2), respectively. Corn oil was heated in 140 degrees C, 200 degrees C, 240 degrees C, after 60 s-300 s, then detected the fatty acid, POV and AV. Together with the internal segment of the globus pallidus (GP(i)), the pars reticulata of the substantia nigra (SNr) provides a main output nucleus of the basal ganglia (BG) where the final stage of information processing within this system takes place. Secondary, the relation between clinical outcome and disease stage, waiting time to radiation (WT) and chemotherapy schedule was explored. Sets of genes encoding glycosyltansferases were transduced by viral infection followed by multi-color cell sorting based on coupled expression of fluorescent proteins.

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Threat sensitivity, incentive sensitivity, and the experience of relief. Reactivity with the latter mAb has been previously shown to segregate with chromosome 12. The synthesis and properties of iridium(III)-cored dendrimers with carbazole peripherally functionalized beta-diketonato dendrons. Compared with Western countries, PMC candidates from non-Western countries are younger, with more severe valve stenosis. Guidelines on live demonstrations of thoracic and cardiovascular surgery: pros and cons. It is suggested that targeting the extension phase represents an area potential of treatment with the greatest possible impact. We examined self-reported data from NCCCP sites during 2007 to 2010, supplemented with data from the National Cancer Institute Cancer Therapy Evaluation Program.

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The impact of renal function on clinical outcomes of patients without chronic kidney disease undergoing coronary revascularization. The signal peptide peptidase is required for pollen function in Arabidopsis. For LPME in combination with GC, the porous hollow fiber was filled with 15 microl n-octanol as the acceptor solution. Maintaining adequate fluid-pump flow rates may help to lower joint fluid temperatures and protect articular cartilage. Enhancing our view of the doubly committed ventricular septal defect. To evaluate the location of the eye and tonometry device that provides the most accurate intraocular pressure (IOP) measurements in eyes with Boston type 1 keratoprosthesis. A high clinical suspicion and early laparoscopic management correlate with favorable maternal and fetal outcomes. Generation of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured postnatal cells.

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Robotic dissection of the planes between the bladder and vagina anteriorly and between the vagina and rectum posteriorly was performed. To evaluate the accuracy of magnetic resonance imaging (MRI) in bladder cancer staging as well as differentiating superficial from invasive tumors and organ-confined from non-organ-confined tumors. Better reporting is needed on research design and intervention implementation. This study was designed to evaluate the effects of roxithromycin (RXM), a newly synthesized macrolide antibiotic, on cytokine production from mast cells. Sequential sectioning of the fibular collateral ligament, popliteofibular ligament, and popliteus tendon all significantly increased varus translation at full extension, 60 degrees , and 90 degrees of knee flexion. We present two case studies to illustrate the application of Corra to commonly performed LC-MS-based biological workflows: a pilot biomarker discovery study of glycoproteins isolated from human plasma samples relevant to type 2 diabetes, and a study in yeast to identify in vivo targets of the protein kinase Ark1 via phosphopeptide profiling. Activation of caspase-3 after daunorubicin or doxorubicin treatment of either nonactivated or activated lymphocytes was demonstrated by the cleavage of poly(ADP-ribose) polymerase, which was, as apoptosis, inhibited by the peptide benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone.

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Density-functional theory (DFT) and ab initio calculations have been used to investigate the effect of a complexed lithium cation on the radical-clock rearrangement of the 2-norcaranyl radical to the 3-cyclohexenylmethyl radical. Transient expression of B19 parvovirus gene products in COS-7 cells transfected with B19-SV40 hybrid vectors. In the adherens junction beta-catenin and plakoglobin serve to link classical cadherins to the actin-based cytoskeleton. The Malay and English versions of the ADDQoL questionnaire were administered to patients attending routine outpatient visits in three primary hospitals and a public clinic. This contribution addresses the problem of solute dispersion in a free convection electrophoretic cell for the batch mode of operation, caused by the Joule heating generation. There was no relationship between the density of each endocrine cell type and fetal age, but there was a significant increase in the relative density (percentage total endocrine cells) of D cells from 10-20 weeks (p less than 0.01). Moreover, cytotoxicity of the released vancomycin was assessed using osteoblast cultures, and after 14 days of culture in the presence of vancomycin, cells were able to remain viable, increasing their metabolic activity and colonizing the granules, as observed by scanning electron microscopy and confocal laser scanning microscopy. Dihydrate birefringent calcium oxalate or Weddellite calcification. To discover genetic polymorphisms among these varieties, five loci within the nuclear and chloroplast genomes were screened.

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In a Dutch sib pair, a shared 9-Mb homozygous region was found on 11q13.1-q13.5 that encompasses the CABP4 gene, previously implicated in autosomal recessive incomplete congenital stationary night blindness (CSNB2) in two small families. This original case report may benefit both gynecologic oncologists and female pelvic surgeons and reconstructive surgeons to keep urethral diverticulum in the differential diagnosis when faced with a bleeding midline anterior vaginal mass. Chemical modification of the amino groups and the guanido groups in cranberry bean alpha-amylase inhibitor molecule resulted in rapid loss of the inhibitory activity, respectively. Chikungunya: a paradigm of emergence and globalization of vector-borne diseases. Sleep curtailment is accompanied by increased intake of calories from snacks. It is unclear whether these abscesses differ in presentation or other characteristics from their non-MRSA counterparts. Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis. NTCP was calculated for seven organs by postulating a dose distribution of maximum nonuniformity. jostii, showed TDG degradation activity only when grown in the presence of TDG as the sole sulfur source.

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Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria. Animal research versus humane use: the struggle to sustain our research advances. Detailed knowledge regarding the acquisition and transmission of infectious agents facilitates a more comprehensive approach toward prevention. Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates. The average third of the left uterine horn was removed, 4mm x 4mm patches in liquid environment were made, and self-transplanted in the rat mesenterium with a single stitch, and the endometrial surface of the endometriotic implant facing the lumen of the peritoneal cavity. Diagnosis may be easily established in the light of clinical history, which can be aided by imaging studies to pinpoint the exact location. Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface.

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Tumor cells express TF and spontaneously release TF-positive microparticles (MPs) into the blood. The extent of the induction inversely correlated with the severity of mucosal lesions, suggesting an important role of HSP70 in gastric mucosal defence. Total thyroidectomy is the accepted standard treatment for benign goitrous enlargements. Multi-institutional prospective studies may better identify patients at high risk. Inconsistent with other cross-sectional studies mostly conducted in industrialized countries, our study indicates that exposure to animals may increase the occurrence of respiratory symptoms and diseases in children, and the associations with respiratory symptoms strengthened with higher levels of animal exposure parental atopy did modify the effect of pet exposure on persistent phlegm but not on doctor-diagnosed asthma. However, it was also found to be actively secreted by both mf and adult worms. A current and charge conserving scattering theory is presented that accounts for this observation with a relaxation time given by the electronic transit time in the circuit. Both TDF and SRM are safe and effective analgesics for the management of chronic cancer pain. Changes in KIT scores by treatment group showed numerically greater and more often statistically significant improvements from baseline to each assessment for children receiving romiplostim versus placebo. Effect of interleukin-1-beta and tumor necrosis factor-alpha on cartilage proteoglycan metabolism in vitro.

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Quantitative assessment of marine sponge cells in vitro: development of improved growth medium. Notably, the use of a preorganized zinc source led to drastic changes in the formation rate of ZIF-8. This technique has been applied to the study of RNA synthesis in the course of regeneration. Colonoscopic localization accuracy for colorectal resections in the laparoscopic era. In contrast to native Wld(S) mutants, distal axon stumps remained continuous and ultrastructurally intact up to 7 weeks after injury and motor nerve terminals were robustly preserved even in older mice, remaining functional for 6 d.

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TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion. Spinal anaesthesia for caesarean section in the neurontin 800 mg pill presence of respiratory failure and spinal metastases from a soft tissue clear cell sarcoma. This paper reports the antigenicity of the fusion region of the influenza virus hemagglutinin (HA). Practices should maintain focus on these qualities, as well as on patient education regarding the relevant differences between FM and IM physicians. In this study, we compare results from statistical mapping with robotic TMS to results achieved from direct stimulation done during tumor surgery. We performed a quantitative analysis of cerebral microvasculature from newborn puppies, a model for neonatal periventricular and intraventricular hemorrhage, at the light and electron microscopic level. There are contradictory reports about the relationship between fetuin-A and atherosclerotic process.

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Scale keratins are larger than feather keratins and the size difference is mainly attributable to four 13-amino acid repeats between residues 77 and 128 which compose a peptide sequence rich in glycine and tyrosine. Combined hepatocellular and cholangiocarcinoma of the liver is relatively infrequent, and its pathogenesis remains obscure. To provide more valuable information from the breast mass for radiologist, an enhanced mass segment method is presented. Morphologically distinct bacteria (three), yeasts (five), and filamentous microfungi (two) were used as indicator species. Retrospective review of consecutive surgical procedures para que sirve el medicamento enalapril de 10 mg by a single surgeon, using a consistent technique during a 9-year period. The telangiectasia gave a low intensity signal on T1 sequences in 2 of the 9 cases and a discretely high intensity signal on T2 sequences in all cases. Prevalences of overweight and obesity are high in coronary artery disease patients in Europe. In four of the families (3, 5, 6 and 7) no brain damaging factors could be traced in the prenatal, perinatal or postnatal periods, and genetic main etiologies were strongly suspected. The forest fragments surrounding the 192-ha Boabeng-Fiema Monkey Sanctuary (BFMS) in central Ghana contain small populations of Colobus vellerosus.

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Semantic differential scores of white and nonwhite respondents favored the receiver-assisted version, indicating that the materials are appropriate for use with a racially mixed target audience. Firm size and occupational injury and illness incidence rates in manufacturing industries. To describe a method for performing computed tomography (CT)-guided hookwire localization using a radial approach for metallic marker clips placed percutaneously after SVAB. To elucidate their structures, metabolites were isolated and analyzed by mass spectrometry and nuclear magnetic resonance spectroscopy. Association of these genes with susceptibility to RA was analyzed both independently and after stratification by one of the genotypes. Aged DBA/2 mice may constitute a useful model for senile unilateral cataract, probably caused by early uveitis. The committee created a database of tests used to diagnose and monitor dry eye, each compiled by an expert in the field (rapporteur) and presented within a standard template. In recent years, it has been shown that glutamate can also be toxic to white matter oligodendrocytes and to myelin by this mechanism.

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Polybrominated diphenyl ethers (PBDEs) are ubiquitous, bioaccumulative flame retardants. Patients under mechanical ventilation for more than 24 h who successfully passed the spontaneous breathing trial were included in the study. The effects of downward airflow on the burning rate and/or burning intensity of square alcohol pool fires for different airflow speeds and directions have been studied experimentally in an inclined wind tunnel. In the present study, the authors used confirmatory factor analysis to compare a self-report measure, the PTSD Checklist (PCL), and a structured clinical interview, the Clinician-Administered PTSD Scale (CAPS), in 2,960 utility workers exposed to the World Trade Center Ground Zero site. In addition, official government documents were analyzed as sources of both data and detailed statements of policy. Exogenous surfactant therapy to prevent respiratory distress syndrome. The influence of classical back and neck massage on the functional state of the cardiovascular system and the frequency-time characteristics of its variability in the adolescents. Different methods of evaluating the intensity of load at which this transition takes place are discussed. Blood flow quantification with permeable contrast agents: a valid technique?.

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Did FDA Decisionmaking Affect Anti-Psychotic Drug Prescribing in Children?: A Time-Trend Analysis. It is concluded that this formulation has no effect on starch digestion in humans. This preferential growth of tumor cells in the presence of tissue specific stroma may be used as an in vitro model for the study of the role of stromal cells in tumor cell spread. This study aimed to determine whether the MS and MV patterns in ME-NBI differ according to the histologic type, invasion depth, and mucin phenotype of early gastric cancers (EGCs). The use of immersion hypothermia on the ipsilesional UE in association with sensory training of the contralesional UE improved motor function and sensitivity in the contralesional UE of individuals with chronic stroke. Cerebellar ataxia with elevated cerebrospinal free sialic acid (CAFSA). The generation of spectral mutants of the green fluorescent protein (GFP) set the stage for multiple-color imaging in living cells.

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