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Bigonyl (Glimepiride)

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Bigonyl tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar. Bigonyl lowers your blood sugar in about 2 to 3 hours after you take the medication. This is why it is important to take the medication with your largest meal of the day.

Other names for this medication:
Accuglim, Adglin, Bestoglim, Chempride, Conpride, Diaglim, Diapride, Dipride, Exermet, Gemer, Glenavon, Glimecure, Glimefide, Glimerit, Glimetop, Glimex, Glimid, Glimide, Glimiwa, Glimpid, Glucoryl, Glycomet, Glymon, Keogli, Metgli, Ozopride, Pionorm, Piotop, Prymia, Rismet, Sulfoglim, Supride, Voglow, Zoryl, Zulip

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Also known as: Glimepiride


Generic Bigonyl is the medication of high quality, which is taken in treatment of type 2 diabetes. The target of this perfect remedy is struggle against type 2 diabetes. Bigonyl is also known as Glimepiride, Diapride, Amyline, Euglim. Generic Bigonyl is acting by stimulating the pancreas to produce more insulin. It is sulfonylureas. Generic name of Generic Bigonyl is Glimepiride. Brand name of Generic Bigonyl is Bigonyl.


Usual Adult Dose for Diabetes Type 2:

Initial dose: 1 to 2 mg orally once a day Maintenance dose: Increase in 1 or 2 mg increments no more frequently than every 1 to 2 weeks based on glycemic response Maximum dose: 8 mg per day Comments: -Administer with breakfast or first main meal of the day. -In patients who are at increased risk for hypoglycemia, start with 1 mg orally once a day and titrate slowly. -When patients are being transferred to this drug from a longer half-life sulfonylurea, monitor 1 to 2 weeks for overlapping drug effect. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1 mg orally once a day; titrate slowly and monitor closely

Usual Pediatric Dose for Diabetes Type 2:

Not recommended because of adverse effects on body weight and hypoglycemia.

Detailed Bigonyl dosage information


If you overdose Generic Bigonyl and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Bigonyl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Avoid exposure to sunlight or tanning beds. Glimepiride can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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Candidate gene analysis of 21q22: support for S100B as a susceptibility gene for bipolar affective disorder with psychosis. They also share a number of messenger molecules such as cytokines and chemical mediators. Vertical Banded Gastroplasty for Sleep Apnea Syndrome Associated with Morbid Obesity. Vildagliptin can be used in patients with type 2 diabetes mellitus and renal impairment. The inhibition was not additive to that of the lysosomotropic base methylamine, indicating that Z-Phe-PheCHN2 and Z-Phe-AlaCHN2 only affect lysosomal degradation. Furthermore, the AS-N and AS-NC were generally more effective than AS-C in reducing the ALDH-1 activity. SLNB before NC is a feasible and an accurate diagnostic tool to predict the pre-therapeutic axilla status. School based interventions and tobacco education are necessary to prevent initiation and cessation of tobacco use. The amino acid sequences of SsuABC and TauABC exhibit similarity to those of components of the ATP-binding cassette transporter superfamily, suggesting that two uptake systems for alkanesulfonates are present in E. MicroCT image data of a modern human skull were segmented to reconstruct digital models of the antagonistic right M1 and M1 and the dental supporting structures.

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On the basis of recent adult studies, the prospect of immune tolerance in pediatric renal transplantation remains hopeful and may be ready for extension to the adolescent population. Morphological changes of ulcerative plaque in patients received carotid angioplasty and stenting (CAS). Both the ratio of plasma aldosterone concentration to plasma renin activity and cardiac expression of the MR and serum/glucocorticoid-regulated kinase 1 genes were decreased to a greater extent by eplerenone than by tempol. Immunocytochemistry in combination with light microscope examination of whole mounts and epoxy sections as well as electron microscopy, were used to assess the phenomena. We have studied the dependence of the reactivated movements on the ATP concentration and have also examined the nucleotide specificity of the reactivation. Therefore, to alter the substrate specificity and increase the amount of Pro-Gly, we selected amino acid residues that might affect the enzyme activity, Ser85 corresponding to Pro85 of BL00235, and His294 on the results from previous studies and the predicted structure of TabS. The presence of a foreign body in the gastrointestinal tract constitutes a common pathology, considering surgical clinical practice. Delayed disengagement of attention from snakes in children with autism.

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Glial activation may be a novel therapeutic target in pediatric epilepsy. A selective antagonist of S2-serotonergic receptors, ketanserin, was administered intravenously during right heart catheterization to 14 patients with pulmonary hypertension complicating systemic sclerosis. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We demonstrated successful reverse contact printing onto the surface of thin layers of PDMS with stiffness ranging from 30 KPa to 3 MPa. Ultrastructurally, the inclusions contained tubular, granular, crystalline, and electron-dense homogeneous structures in addition to unclassifiable nuclear bodies. The biological activity resided in the second peak, which corresponded to the low molecular weight fraction of 6,000-14,000. In this work, a series of 9-ethyladenine derivatives bearing phenylalkylamino, phenylakyloxy or phenylakylthio groups of different lengths at the 2-position were synthesised and tested against the human adenosine receptors. Follow-up six months and five years after operation, there is no recurrence. Overt hypothyroidism is often recognized as an important cause of depression, but in sub-clinical cases, results are inconsistent and most prior studies have involved small samples. Overall, the accuracy and precision of currently available IGRT technology exceed published experience with the accuracy and precision of contouring for planning.

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After normalization, the mean shortest distance between the contour lines of straight walking and walking at an angle had a mean of 0.22 cm (SD: 0.06 cm) for the forefoot and 0.14 cm (SD: 0.06 cm) for the heel. A model is proposed for calculation of the shape and contact angle of droplets placed on solid substrates, which is based on the oblate spheroid approximation. The Impact of Deferoxamine on Vascularity and Soft-Tissue Biomechanics in a Rat TRAM Flap Model. Overexpression of truncated smad2 in cyclops mutant embryos leads to a rescue of the eye and floorplate defects. Colloidal carbon was then given intravenously to identify the leaky vessels. Randomized Controlled Trial Comparing the Efficacy of Impedance Control and Temperature Control of Radiofrequency Interstitial Thermal Ablation for Treating Small Hepatocellular Carcinoma. Use of electrochemically activated aqueous solutions in the manufacture of fur materials. Musculoskeletal research at the National Institute of Arthritis and Musculoskeletal and Skin Diseases: a snapshot. In all but one case the palsy was found on the more hypoplastic side of the face. Direct effects of statins on cells primarily involved in atherosclerosis.

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Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial. An understanding of the embryologic development of the vena cava and its tributaries is necessary to understand the genesis of these sometimes complex anomalies and their accompanying anatomic variants. This study compared the associations of past and present socio-economic circumstances with physical functioning between employees from Finland and Britain. Methyl-acetylenicputrescine (MAP), an inhibitor of polyamine biosynthesis, reduces the frequency and cytolytic activity of alloantigen-induced LyT 2.2 positive lymphocytes in vivo. Dynamic changes in the medial arch of the foot in childhood during walking.

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This review provides an overview of implantable devices as well as a critical assessment of a 24-h contact lens sensor. Our results suggest an inverse correlation between serum interferon alpha and the amount of interferon alpha produced in leukocyte cultures in male homosexuals with AIDS or generalized lymphadenopathy. This article presents the design and characterization of polyamphoteric flocculants with a tunable, zwitterionic character for the enhanced separation of biocolloidal suspensions of yeast, wastewater, microalgae, and potentially other cellular systems. There is compelling evidence to suggest that changing the subcellular location of a protein can also alter its function, and that diversity in subcellular targeting within gene families is common. Individuals living with diabetes develop a range of different strategies to create stability in their lives and enhance their well-being. Sequencing of the toxin by Edman degradation and mass spectrometry revealed a 63 amino acid residue peptide with 4 disulphide bonds that belongs to the three-finger toxin family, but with a unique modification of its disulphide-bridge scaffold. The finding that melanomas contain exclusively vimentin intermediate filaments may prove useful in differential diagnosis of melanomas from other tumor types. Medication safety could be significantly improved by implementation of counter-measures specific to the identified risk factors. We describe a modification to the technique of band placement and a manoeuvre to aid the placement of staples when the TA90B staple gun is used. These findings indicate that Sorbinil treatment in diabetic rats prevented and reversed both Sorbitol accumulation and depletion of nerve myo-inositol in the sciatic nerve.(ABSTRACT TRUNCATED AT 250 WORDS).

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Recent developments in the acquisition and processing of NMR data sets facilitate the recording of ultra-high-resolution NMR spectra in a reasonable time. Syndesmophyte formation may cause falsely increased BMD of the spine. In the beta (13-30 Hz) frequency band, the MI of the affected hand (Ahand) elicited a significantly lower smallworldness and local efficiency (Eloc) versus the unaffected hand (Uhand). Mitochondrial DNA sequence divergence among greenbug (Homoptera: aphididae) biotypes: evidence for host-adapted races. Patient records-including the results of VCUG, renal sonography, Dimercapto succinic acid (DMSA) scintigraphy, and periodic urinary analysis-were also reviewed to determine the outcome of treatment. In Experiment 2, listeners estimated the terminal distance of sounds that approached but stopped before reaching them. This hypothesis needs to be tested with equally intense taxon sampling of mainland Africa as for Madagascar.

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The anatomical localization and exact mechanism of carbachol-induced WDS remain to be elucidated. Medicine and ethics in the performing arts: the problems of caring for high-level performers. The use of plant biomass as feedstock for biomaterial and biofuel production is relevant in the current bio-based economy scenario of valorizing renewable resources. The first WGS in cats was conducted on a trio segregating for LCA and the bobbed tail abnormality. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Survival rates were then determined by a MTT assay, while vascular endothelial growth factor receptor (VEGFR)-1 and -2 expression was measured by flow cytometry and apoptotic cell death rates were investigated using an Annexin assay. The release of metallic ions into the oral cavity may both inhibit bacterial growth and influence bacterial adhesion.

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The investigations were carried out in 50 normals by means of Fitzgerald-Hallpike bithermal and Torok monothermal tests. Glycoxidized HDL, HDL enriched with oxidized phospholipids and HDL from diabetic patients inhibit platelet function. In addition, the cytoprotective effects of the catalytic antioxidant are associated with correcting mitochondrial dysfunction ROS, DNA oxidation, and decreases in intracellular GSH. This indicates that by changing the frequency (chirp) of the laser pulse we can control the ion yield of a chemical reaction. To review the literature evaluating outcomes resulting from expansion of the bipolar disorder (BD) diagnostic category. Bilateral injection of sarpogrelate did not alter blood pressure or reflex changes in heart rate in response to phenylephrine-induced increases in blood pressure or nitroprusside-induced decreases in blood pressure. In these structures, CNCs were aligned along the core in the core-shell case, or on the wall of the hollow cylinder in the hollow fiber case. This distinguishes the identified domain from other regulatory parts with negative influence on transcription. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes.

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An appropriate chaperone may also protect healthcare practitioners from false accusations. The tendency for clot formation and platelet adhesion was greater in noncoated and lipid-coated tubing than in heparin-coated tubing. Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium. To efficiently process a cluttered scene, the visual system analyzes statistical properties or regularities of visual elements embedded in the scene. Furthermore, isoflurane augmented hepatic microvascular blood flow and lowered the malondialdehyde content within the liver compared with control animals. This study examines the expression of IRS5/DOK4 in a panel of lung cancer cell lines and tumor specimens. Among eight purified lipid A fractions, there was glimepiride medication interactions heterogeneity of mitogenic activity, but the relative activity could not be predicted by limulus amebocyte lysate assay. High-density lipoprotein (HDL), a natural SR-B1 ligand, was shown to increase the in vitro infectivity of retroviral pseudoparticles bearing HCV envelope glycoproteins and of cell culture-derived HCV (HCVcc), suggesting that SR-B1 promotes viral entry in an HDL-dependent manner. Intravesical or intrarectal instillation of Maalox, a well-known material for protection of mucous epithelia, was performed in 3 cases of radiation cystitis and one case of radiation proctitis, resulting insuccessful control of hemorrhage.

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Further studies on larger patient populations are required to validate our results. We reviewed the medical charts of 10 patients who had bronchopulmonary actinomycosis between November 1, 2002, and January 31, 2008. Metastasis remains an incurable common complication in patients with gastric cancer. Cartilage content of proteoglycans decreases early in induced degenerative hip joint disease. A fast-gel-filtration method has been optimized with respect to column design, centrifugation time and speed and, delay between sample application and column centrifugation.

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The lack of clinical signs of infection, negative culture of preoperative joint aspirate, and intraoperative specimens do not exclude the presence of bacteria on the surfaces of spacers. We demonstrate that, in response to the intradermal injection of interleukin-8, neutrophils are preferentially recruited to a unique subset of venules that express high levels of intercellular adhesion molecule-1 and low levels of caveolin-1. We used the obtained phylogeny to explore host plant family association and geographical distribution to investigate if host shifts and allopatry have been instrumental in the speciation of these leafmining insects. The descending left coronary artery of male rats (Rattus norvegicus) was ligated to produce a MI. Biochemical examination of cardiac muscle from clinical cases of cardiomyopathy revealed that the concentrations of three enzymes were significantly altered. But there still remains some problems to be solved: (1) Are there any difference between bipolar precordial leads and lead V5 in wave forms?. Serum was analyzed for the following constituents: 3-hydroxybutyrate (3-HB), glucose, total protein, albumin, urea, creatinine, aspartate aminotransferase, alkaline phosphatase, cholesterol, triglycerides, cortisol, T3, T4, total calcium, magnesium, and phosphorus, using commercially available kits.

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In vitro evidence supports the presence of glucokinase-independent glucosensing mechanisms in hypothalamus and hindbrain of rainbow trout. The signature of climatic change, during and after the Pleistocene, on the distribution of the millipede genus Narceus is evident in the genetic data presented. In the DWI, axial MRI scans were performed after segmentation inderal drug description based on SENSE technique, and all images were merged into whole body image reconstruction by software. This auxiliary method allows the position and design of the implant, as well as the perforation sequence to be programmed, thus optimizing the clinical results. Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro. Results from inversion of nine pumping tests show expected geologic features, and uncertainty bounds indicate that hydraulic conductivity is well constrained within the central site area. In the present report, reentry was achieved in 12 of 12 patients with the use of the cannula. The hand function recovered satisfactorily, and the sensation was 51-53 at 6 months after operation.

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A comparison between cetirizine and ondansetron in preventing postoperative nausea and vomiting in adults. The authors found higher community what schedule of drug is xanax and valium acquisition rates among preschool children for all serotypes and higher within-household transmission for 6A and 14. The relationship between the percentage of oxygen consumption reserve and percentage of heart rate reserve in patients on optimized beta-blocker therapy was reliable, but this relationship was unreliable in non-optimized heart failure patients. The core particles displayed RNA transcriptase activity while the virion did not. Using this method, deamidation that occurred during sample preparation resulted in a molecular weight increase of 3 Da instead of 1 Da. Therefore, we successfully established an SHIV system expressing IL-6, and this is the first report of an SHIV expressing a Th2-type cytokine. Effects of training attendance on muscle strength of young men after 11 weeks of resistance training. Explaining effervescence: Investigating the relationship between shared social identity and positive experience in crowds. When compared to 4-thiomethoxy substituted pyrimidine 2 4-N-substituted terpenyl pyrimidines 5(a-d) and 7(a-g) were found inactive.

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We report a patient with respiratory failure due to expiratory central airway collapse successfully treated with airway stents. Dual chamber pacemaker implantation in dogs with atrioventricular block. Youth fitness in Georgia was related to socioeconomic, demographic, and geographic themes. The growth defect of TAp73-deficient cells can be rescued by either enforced G6PD expression or the presence of nucleosides plus an ROS scavenger. We submit that by considering more fully an ecological context, researchers may gain additional insights into the underlying genetic basis of ecologically relevant phenotypic variation. The authors analyzes therefore different nosological unites, or clinical syndromes associated with excessive production of gastrin, vasoactive intestinal polypeptide, glucagon and somatostatin. Amputation occurred in four patients, who had type III fractures. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system. Complicated postbulbar duodenal ulcer: the characteristics of its diagnosis and surgical technic and management.

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Biotic and abiotic controls on nitrogen leaching losses into waterways during successive bovine urine application to soil. Thus, CRP levels can be used to predict, assess and monitor response to treatment with TNFalpha-blocking agents, and may be helpful in determining the optimal TNFalpha-blocker dosage. Candida infections are a source of significant mortality and morbidity in the neonatal intensive care unit. Geographic proximity is an important component of access to primary care and the pharmaceutical services of community pharmacies. Composition of the residual solid fraction and relative proportions of different components, as a function of the processing conditions, could be established. These developments open the possibility of incorporating SMPs into device design, which can lead to vast technological improvements in the biomedical field. The location of impacted maxillary canines varies greatly in 3 planes, and the resorption of neighboring permanent incisors is common. To describe evidence-based practice (EBP) beliefs and behaviors of nurses who provide cancer pain management. Molecular characterization of field isolates and vaccine strains of infectious bursal disease zyvox iv dose virus. Fundamentals of calcium metabolism, intestinal absorption, urinary excretion and balance are recalled.

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The phosphatidylcholine specific transfer protein (PCTP) from bovine liver was used to retailor the molecular species composition of phosphatidylcholine (PC) in the membrane of normal (AA) and sickleable (SS) human erythrocytes. Pathohistological grading criteria for SCC from various sources were used. Increase in the incidence of cervical and trochanteric fractures of the proximal femur in Niigata Prefecture, Japan. A 28-year-old man was admitted because of fever and abdominal pain. Taken together, these results add further evidence to support the notion that 3,5-T(2) is a bioactive iodothyronine. After the operation, the serum human chorionic gonadotropin-beta (hCG-beta) level was 800 mg motrin dosage frequency slightly elevated, and the combination chemotherapy with methotrexate, vinblastine and cisplatin (MVC) was administered. HRV was determined based on time-domain, frequency-domain, and nonlinear analyses. The Y-family polymerases also contact the DNA major groove via the unique little finger domain, but they generally lack contacts with the major groove at the nascent base pair. We have recently developed a new technique to objectively identify erythrocyte cohorts of defined age in mouse blood. The improved antitumor activity of doxorubicin in combination with naringenin was also investigated in vivo.

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The abnormal glucose homeostasis was dependent on upregulation of Hif-1alpha expression, and deletion of Hif1a in Vhl-deficient beta cells restored GSIS. The nature of the inhibition by ZK 36 374 against NA in the rat atria seems to be different from that of PR since the calculated pD2 values of NA were the same for chronotropic and inotropic responses in control experiments and in the presence of PR while the pD2 value of NA for chronotropic response was significantly lower than that for inotropic response in the presence of ZK 36 374. Differences in capacitance of the vessels may be related, in part, to greater collagen content in the inferior vena cava. However, increased specificity results in reduced sensitivity and the missing of malignant SPNs. Therefore, a histologic discrepancy may exist between specimens obtained by forceps biopsy and by endoscopic resection. Immunofluorescent staining experiments with these three antisera showed a consistent nuclear distribution of hMYH, excluding the nucleoli. Vibratome-cut slices had lower ATP levels than chopper-cut slices. Kinetic and ionic properties of the human HCN2 pacemaker channel. Future efforts will be directed toward improving survival and quality of life.

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Rapid response of transient acantholytic dermatosis to selenium sulfide treatment for pityriasis versicolor. Despite World Health Organization recommendations that all TB suspects should undergo sputum microscopy before treatment, results are available for further assessment for only one third. Small renal masses: incidental diagnosis, clinical symptoms, and prognostic factors. This appears to be the first study to explore benefits what is the starting dose of allopurinol across micro, mezzo and macro social levels and to include discussion of more diverse potential benefits such as individual and organizational social capital, leadership, and advocacy. Cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of stem cells. An incidentally discovered right atrial mass excised from the heart of a 51-year-old woman was found on pathological examination to be an epithelioid hemangioendothelioma.

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Taken together, the epidemiological data available in the current scientific literature do not support the notion that higher consumption of vegetables may have a significant impact on the risk of venous thrombosis. Clinical and morphologic studies were made of 20 cases of guttate hypomelanosis. Of 141 human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the SET(TAF-Ibeta)-NUP214 fusion gene transcript. Valvuloplasty with a paclitaxel-eluting balloon prevents restenosis in an experimental animal model of aortic stenosis. Effects of narcotics, including morphine, on visual evoked potential in rats.

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