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Bionil (Glibenclamide)
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Bionil

Bionil is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Bionil is only available as a generic drug; all brands have been discontinued. Bionil is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Afdiex, Benclamet, Betanase, Betrol, Codica, Combidos, Daocon, Daonil, Diabetnil, Diabetrol, Diolin, Duotrol, Dutrol, Euglucon, Eumet, Glibact, Glibenclamide, Glibet, Glibson, Glifil, Glimsug, Glitrac, Glucomin, Glucored, Glucosafe, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybid, Glyboral, Glybovin, Glybovine, Melitus, Metclam, Metica, Monomet, Pionorm, Sugatrol, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglucored, Triglycomet

Similar Products:
Elavil, Arava, Altace, Chloromycetin, Avelox, Catapres, Exelon, Aristocort, Desyrel

Also known as: Glibenclamide

Description

{name} is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. {name} belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. {name}, micronized may be used alone or with another oral medicine such as metformin.

{name}, micronized is available only with your doctor's prescription.

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Bionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Bionil and metformin if you are allergic to Bionil or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Bionil and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Bionil and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Bionil and metformin.

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Phytoplanktons and DNA barcoding: Characterization and molecular analysis of phytoplanktons on the Persian Gulf. The presence of a small unrecognized abdominal aortic aneurysm was considered to be the cause of thrombosis in this patient. Because the initial experience with this approach resulted in an unacceptably high incidence of facial numbness, a gradual dose and volume de-escalation was performed over several years. Patient records from the Kansas City Free Dispensary, 1906-1912, provide material for a case study of race in early twentieth-century medicine. Moreover, F2 attenuated the glioblastoma FPR expression, a new molecular target for glioma therapeutics, which has been shown to play important roles in glioma cells chemotaxis, proliferation and angiogenesis in addition to its promotion to tumor progression, but did not affect FPR mRNA expression in U-87 cells. However, the role of the gastrin-gastrin receptor (GR) system in the growth of gastric tumors is still unclear. Experiments were performed what class of medication is actos taking advantage of a dedicated set up at the European Synchrotron Radiation Facility (ESRF, Grenoble, France), which allowed quantitative imaging at a spatial resolution of about 5 microm.

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