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Biproate (Divalproex)

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Biproate is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.

Other names for this medication:
Biproate, Desval, Devot, Dicorate, Discern, Disorate, Divalin, Divalpro, Divalrate, Divanet, Dixval, Elival, Epirate, Epival, Epsoval, Genval, Navalin, Nepilex, Sodaval, Spikalon, Trival, Valcort, Valcot, Valimep, Valop, Valowin, Valporil, Valporl, Valpret, Valtaril, Valtec, Valtril, Valver, Valvo, Velpo, Velze, Vinchorate, Zoret

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Acticin, Soma, Trileptal, Deltasone, Arava, Prometrium, Persantine, Claritin, Requip

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Also known as: Divalproex


{name} ER comes in different pill forms that are for different uses.

{name} ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications.

{name} ER tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).


This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Biproate DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Valproic acid dosage information

Side effects

The most common side effects associated with Biproate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Biproate Sprinkles if you are allergic to it, or if you have:

liver disease; a urea cycle disorder; or a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.

Biproate Sprinkles can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.

Tell your doctor if you have ever had:

liver problems caused by a genetic mitochondrial disorder; depression, mental illness, or suicidal thoughts or actions; or a family history of a urea cycle disorder or infant deaths with unknown cause.

Some people have thoughts about suicide while taking Biproate Sprinkles. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using Biproate Sprinkles during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant. Using this medicine during pregnancy can also affect cognitive ability (reasoning, intelligence, problem-solving) later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby.

If you take Biproate Sprinkles for seizures or manic episodes: The benefit of preventing seizures or manic episodes may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking this medicine without your doctor's advice.

Do not use Biproate Sprinkles to prevent migraine headaches if you are pregnant or you could become pregnant.

If you are not pregnant, use effective birth control to prevent pregnancy while using Biproate Sprinkles. Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with this medicine and make it less effective in preventing seizures.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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