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Calaptin (Verapamil)

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Calaptin is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,16 and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like diltiazem and flunarizine, but is chemically unrelated to other cardioactive medications.

Other names for this medication:
Calaptin, Covera, Isoptin, Vasopten, Veramil, Verapamil, Verelan, Verpitos, Zolvera

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Also known as: Verapamil


Verapamil is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Verapamil is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, verapamil relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .


This section provides information on the proper use of a number of products that contain verapamil. It may not be specific to Calaptin. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Swallow the extended-release tablet whole with a full glass of water. Do not break, crush, or chew it. It is best to take this medicine with food .

If you cannot swallow the verapamil extended-release capsules, you may open it and sprinkle the pellets contained in the capsule on one tablespoon of applesauce. This mixture must be swallowed immediately with a glass of cool water. The applesauce should not be hot and should be soft enough to be swallowed without chewing. Do not chew or crush the pellets .

If you are taking the extended-release tablets, you may sometimes notice what looks like a tablet in your stool. This is the empty tablet shell that is left after the medicine has been absorbed .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (tablets): Adults—The usual dose is 80 to 120 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For heart rhythm problems: For oral dosage form (tablets): Adults—The total usual dose is 240 to 480 milligrams (mg) divided in three or four equal doses per day. Children—Use and dose must be determined by your doctor . For high blood pressure: For oral dosage form (tablets): Adults—At first, 80 milligrams (mg) three times a day. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release capsules): Adults—At first, 200 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once daily in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor . For oral dosage form (extended-release tablets, 24 hr): Adults—At first, 180 milligrams (mg) once daily at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor .


If you overdose Calaptin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Calaptin overdosage: slow heartbeat, fainting fit.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Calaptin dosage information

Side effects

The most common side effects associated with Calaptin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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Both transcriptional and post-translational regulation can affect protein abundance and cellular localization of these transporters, finely orchestrating uptake, intracellular trafficking, and secretion of iron, copper, and zinc. Cloned lines of human cytotoxic T lymphocytes with specificity for influenza virus. The objective of this study was to determine the relationship between four HRQoL aspects and use of mammography and Pap test screening in US women. Average vertical migration was 1.02 mm superiorly, and average horizontal migration was 0.8 mm medially. Prior to decision making for any surgical or interventional therapy, the right ventricular outflow tract morphology together with additional pathologies need to be assessed. Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats. Implementation of a rapid response team decreases cardiac arrest outside of the intensive care unit. IgG4 specific to Toxoplasma gondii excretory/secretory antigens in serum and/or cerebrospinal fluid support the cerebral toxoplasmosis diagnosis in HIV-infected patients. To report findings for DSM-IV CAD criteria from association analyses performed in large cohorts of African American and European American participants from 3 studies of substance use disorder genetics.

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However, sampling nearshore assemblages does not represent those in eelgrass beds despite considerable overlap and close proximity. Statistical study of the factors influencing the prognosis in tuboplasty operations. Evaluation of the Integrated Services Pilot Program from Western Australia. Transitory myocardial ischemia in patients with vascular lower limb amputation: relationship with long-term atherothrombotic events. SpolvlgA expression highlights this wave of differentiation, where nearly all previous structures are substituted by blastomere-derived embryonic cells. Four SdiA variants were obtained with altered biofilm formation, including truncation variants SdiA1E11 (F7L, F59L, Y70C, M94K, and K153X) and SdiA14C3 (W9R, P49T, N87T, frameshift at N96, and L123X), which reduced biofilm formation by 5- to 20-fold compared to wild-type SdiA in the presence of endogenous indole. Antiliver and antithymus IgG are used to investigate a distribution of tissue-specific and tissue-non-specific immunogenic proteins in thymocyte nuclei.

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Adjuvant chemotherapy for patients with rectal cancer - will the controversy be resolved?. Adalimumab treatment resulted in a statistically significant improvement in outcome measures compared to baseline in patients with moderate to severe interstitial cystitis/bladder pain syndrome. Improved diet quality and increased nutrient intakes associated with grape product consumption by U.S. Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Autophagy occurs in the brain after intracerebral hemorrhage (ICH). Characteristics of the zygote and the cleavage-stage embryo determine the developmental potential of the embryo up to the blastocyst stage. Zinc increases the activity of vitamin D-dependent promoters in osteoblasts.

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Since extracorporeal shock wave lithotripsy is an effective noninvasive procedure that does not require routine anesthesia and hospitalization, with prompt return of the patient to normal life, it must be considered the method of choice in these particular patients. Diverse families of HATs appear to perform a conserved mechanism of acetyl transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. This feeding motivation may be altered by dietary fibre content and source. MicroRNA (miRNA) are small non-coding RNA that act at the post-transcriptional level, regulating protein expression by repressing translation mRNA target. Additionally, the EOCP reproduces the overall relaxation time scales of the correlation functions associated with ionic motion. A swan-neck deformity was found in nine out of 12 cases but corrective surgery was not required. Endoscopic endonasal management of petroclival cerebrospinal fluid leaks: anatomical study and preliminary clinical experience. Active immunotherapy is a new area of research that may be a successful treatment option. Modeling video tic counts in a crossover trial of deep brain stimulation for Tourette syndrome. Smad2 and Smad4 are important for transcriptional and antiproliferative responses to TGF-beta, and their inactivation in human cancers indicates that they are tumor suppressors.

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ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients. Tobacco smoking is known to influence various inflammatory skin diseases and an association between tobacco smoking and hand eczema has been proposed in some studies. Adoptive transfer of delayed type hypersensitivity reactions specific for Leishmania major antigens to normal mice using murine T cell populations and clones generated in vitro. The cytokine caused a drastic decrease in transepithelial electrical resistance within several hours representing an enhanced permeability of PCPEC monolayers. Changes in arbuscular mycorrhizal fungus community along an exotic plant Eupatorium adenophorum invasion in a Chinese secondary forest.

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The strategy was validated by profiling BRs in different ecotypes and mutants of rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana), and the BR distributions in different model plants tissues were determined with the new method. Comparison of upper and lower lip muscle activity between stutterers and fluent speakers. Epidemiologic and ecologic studies suggest that dietary fat plays an important role in the development of obesity. In-office laryngeal surgery is taking on a more commonplace role in the treatment of laryngeal disorders. Improved single-copy integration vectors for Staphylococcus aureus. Microdensitometrically, the F1(P2P6F1) exhibited a significantly higher bone density than did the SAM-P/6. Identification of factors associated with poor outcome may be used for clinical predictions. He improved remarkably on clinical symptoms and CT by treating of dexamethasone and osmotic diuretics, but died of pneumonia.(ABSTRACT TRUNCATED AT 250 WORDS). Influence of pyramin and venzar on some metabolic products of Azotobacter chroococcum.

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Previously, the only option was mitral valve replacement (MVR) with a mechanical or tissue valve. Second neoplasms represent one of the more serious late effects of treatment and are associated with a substantial level of morbidity and mortality. CABIN has been written in Java and is available as a plugin for Cytoscape--an open source network visualization tool. Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture. This is the first clinical case report of a thoracic invasive thymoma metastatic to the ovary with disease noted in the entire abdomen including the pelvis 5 1/2 years after initial diagnosis. Slight marginal staining occurred adjacent to 11 restorations of both S3 and GB. In fifteen of the thirty-six explanted valves, the aortic outlet was narrowed with the three-legged prosthetic cage causing a triangular distortion of the wall. Efforts to control infection have led to the deployment of polysaccharide vaccines and an understanding of antibiotic resistance. The use of the latter substrates, together with overexpressed DNA N-glycosylases, allows detailed studies on the efficiency of the enzymatic release of the modified bases. The signal-to-background ratio for the tested opioid ligand ranged from 3.3 to 12.0.

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Myricitrin protects against peroxynitrite-mediated DNA damage and cytotoxicity in astrocytes. This phase III, randomized trial assessed the efficacy and safety of docetaxel administered either immediately after GC or at disease progression. Data were analysed with Minitab Version 2004 (Minitab Inc, State College, PA, USA). vWF was determined by does klonopin and valium show up the same on a drug test measuring vWF antigen (vWF:Ag) and vWF ristocetin cofactor (vWF:RCo) and by multimer analysis. Urine levels of catecholamines in Greek children with obstructive sleep-disordered breathing. A significant improvement in overall survival (OS) was observed without loosing of the quality of life (QOL) of patients.

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eCS was assessed from archived images, and its discrimination and reclassification prognostic potential was determined. Useful diagnostic techniques for the acute phase of sciatic nerve palsy, an entrapment neuropathy, are not well established. The wide LoA found in this study indicate that the three subscales of the QoV questionnaire (Frequency, Severity and Bothersome.) measure different aspects of the latent trait, quality of vision. Urination disorder following extensive hysterectomy and associated nursing care. Some sudden ultram 150 mg deaths in children with chronic, severe asthma are unassociated with any of the above, making it necessary to entertain still other hypotheses.(ABSTRACT TRUNCATED AT 250 WORDS). Recent studies have proven specific shrinkage of the involved arteries in MMD. In this study we analyse the microbial communities within the human gut and their role in Inflammatory Bowel Disease (IBD).

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Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis. The effect of mode of transport and distance to be traveled on on-scene times (OSTs) has not been well-described. Induction of immune tolerance to RBC, platelet, and neutrophil antigens and IgA. Because of the marketing pressure, there is now a plethora of robots available in some areas. We present the surgical approaches and techniques in a consecutive series of 119 patients treated by the senior author (J.H.) between 1980 and 2007 at 2 different neurosurgical university centers in Kuopio and Helsinki, Finland. The Papanicolaou stain may well be the stain of choice for the identification of microfilariae in the blood. Importantly, the increase of JNK enzymatic activity correlates with the dissociation of GSTpi-JNK complexes and the increased concentration of GSTpi multimer forms.

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Morphogenetic theories that investigate these shapes range from discrete to continuous models, from the variational elasticity to time-dependent fluid approach. pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. The clones were analysed for their viral antigen specificity using serologically defined type A influenza subtypes and chemically synthesized peptides of the HA-1 molecule. Most blood flow from these connections was reversed in the lower PAs of the affected side, reaching the contralateral lungs through the central PAs. After having ruled out other possibilities, the plausible explanation is one, which is not described in the literature. In this proof-of-principle study, one patient with severe anterior vaginal wall prolapse was implanted with an MR-visible mesh. Infection requires fusion of the host and viral membranes, a process that occurs in the host cell endosomal compartment and is facilitated by the envelope glycoprotein fusion subunit, GP2. Long-term memory formation depends on protein and mRNA synthesis that roxithromycin cost in australia subserves synaptic reorganization.

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Solvent-Free Synthesis of Flavour Esters through Immobilized Lipase Mediated Transesterification. Because the results were not in agreement with an ecological trap scenario, where poor habitats are preferred over high-quality habitats, our results suggest a more general case of nonideal habitat selection. Preventing chronic back pain at the workplace: action-research at the workplace. Surface Ag/AgCl electrodes were used to stimulate the posterior tibial nerve using a constant current stimulator and to record the soleus EMG. Physical medicine and rehabilitation and neurology departments of a University Hospital. Recommendations for DNA laboratories supporting Disaster Victim Identification (DVI) Operations--Australian and New Zealand consensus on ISFG recommendations. The early diagnosis and immediate surgical treatment of spinal abscesses remain cornerstones in improving the outcomes of the disease. The SAT9: a quantitative scoring system for the AT9 test as a measure of symbolic function central to alexithymic presentation.

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Other articles in this issue report on guideline adoption and use and the results of the market research on the ACOEM guidelines. Data are compared with related literature, as etiopathogenic mechanisms possibly involved. But if it does, seeing your device used to enhance patient care makes it all worthwhile. Accompanied by a powerful computational data analysis method, new genome-wide screening approaches were used to detect cryptic genomic aberrations. Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. Two novel artificial receptors based on diamide and bearing phenol group and copper(II) have been synthesized. In all parts of the depth profiles, the average concentrations of both magnesium and fluoride were higher in the Japanese than in the Chinese calculus. Interviews were recorded, transcribed, and independently coded for common themes. Patient-reported outcome measures are an important component of outcomes assessment in clinical trials to assess the treatment of femoroacetabular impingement (FAI). We review mechanisms giving rise to iPMF and iHMF, present new data suggesting that inactivity-induced plasticity is observed in inspiratory intercostals (iIMF) and point out gaps in our knowledge.

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The incidence of VAP was not increased in the recent 10 years in our RICU, but the incidence of VAP caused by Acinetobacter baumanii. Species tree phylogeny and biogeography of the noroxin medication Neotropical genus Pradosia (Sapotaceae, Chrysophylloideae). Impact of perampanel on pharmacokinetics of concomitant antiepileptics in patients with partial-onset seizures: pooled analysis of clinical trials. The echocardiographic and clinical predictors of hs-cTnT may be different in ischemic heart failure (IHF) and non-ischemic dilated cardiomyopathy (DCM). Heart transplant (HT) has been considered as a therapy for pediatric end-stage heart failure (HF) for more than four decades. The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats.

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The anti-Factor Xa chromogenic assays now available are likely to provide the most appropriate means of determining plasma concentrations of rivaroxaban and apixaban, and specific assays for dabigatran are in development. Numerous genetic diseases and environmental stimuli affect optic nerve morphology. The second monoclonal antibody, 436G10 (IgG1), reacted with 10/14 melanomas 5/13 carcinomas and sarcomas, 2/7 gliomas and neuroblastomas, and weakly with the fetal cells, but not with the leukemic or lymphoblastoid cell lines. Fiber placement and experiment design was optimized using cadaver animals with live animal measurements acquired to validate the systems capabilities. To ensure the continued success of whole organ pancreas and islet transplantation, deceased donor pancreas allocation policy must continue to evolve. The diversity of how much is clomid in mercury drug N-linked oligosaccharides on human immunodeficiency virus. In addition, we and others documented several gene-environment interactions and epistatic effects of genetic polymorphisms in the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels. This article reviews the course, possible causes, assessment, and treatment of this group of disorders in youth and concludes by examining the implications for nurses and other health care providers of youth with mood disorders. The genetic disassociation of these two proteins from the A- 1A5 -reactive complex suggests that the appearance of the 160,000 Mr protein requires a gene locus that is unlinked to the locus for the 125,000 Mr protein on chromosome 10.

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These data support the need for improvements in school food environments and policies and provide a useful baseline for monitoring change as schools work to make these improvements. The effects of pretreatment and cross-linking agents on properties of porcine plasma protein-based film were investigated. The use of hemosorbents SKN, plastic systems and heparin regional dosing devices made the procedure less traumatic, provided the use of heparin lower doses and application of hemosorption to patients with severe pulmonary tuberculosis. In this study, a human chronic myelogenous leukemia cell line (K562) was induced to differentiate into megakaryocytes by TPA, and erythroid by STI571. This is significant, as this knowledge can then be used to design plasma systems with tailored compositions that will achieve maximum efficacy. Ornithine cyclodeaminase-based proline production by Corynebacterium glutamicum. Liver biopsy: special histologic techniques including immunopathology. There is a large number of Mexican medicinal plants used as a treatment for anxiety and depression disorders.

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