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Calmnir (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Calmnir was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Almac, Alrest, Cleps, Cloam, Clonark, Clonax, Cloneepam, Clonoasig, Clonopam, Clotweet, Clozep, Clozipam, Deptune, Easyfeel, Epitril, Epizam, Escitacalm, Estalonix, Klopam, Lonazep, Meloprax, Nazee, Nozim, Nupam, Ozepam, Prasilife, Repam, Sezolan, Sezolep, Somnotril, Ubitpam, Xenotril, Zeficar, Zepam, Zepamax, Zicam, Zolpidox

Similar Products:
Sovaldi, Keflex, Nolvadex, Omnicef, Singulair, Mellaril

Also known as: Clonazepam


Calmnir, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

Calmnir has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of Calmnir. As a result, Calmnir is sometimes used for certain rare childhood epilepsies; however, it has been found to be ineffective in the control of infantile spasms. Calmnir is mainly prescribed for the acute management of epilepsies. Calmnir has been found to be effective in the acute control of non-convulsive status epilepticus; however, the benefits tended to be transient in many of the people, and the addition of phenytoin for lasting control was required in these patients.

It is also approved for treatment of typical and atypical absences, infantile myoclonic, myoclonic and akinetic seizures. A subgroup of people with treatment resistant epilepsy may benefit from long-term use of Calmnir; the benzodiazepine clorazepate may be an alternative due to its slow onset of tolerance.


Calmnir is used alone or in combination with other medications to control certain types of seizures. It is also used to relieve panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks). Calmnir is in a class of medications called benzodiazepines. It works by decreasing abnormal electrical activity in the brain.

Calmnir comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It usually is taken one to three times a day with or without food. Take Calmnir at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Do not try to push the orally disintegrating tablet through the foil. Instead, use dry hands to peel back the foil packaging. Immediately take out the tablet and place it in your mouth. The tablet will quickly dissolve and can be swallowed with or without liquid.


Benzodiazepines like Calmnir became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Calmnir together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Calmnir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Calmnir may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take Calmnir with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment with Calmnir also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment.

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Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. Of the test soils evaluated, ATS2015 and Edinburgh-M were found to be good choices for the simulated use of endoscopes, as their composition and viscosity most closely matched worst-case clinical material. Study on over-weight, obesity and the exposure to stroke risk factors among 40 year olds and over in a community-based population. Radiographs of the fracture were made before surgery, at six weeks, and at three, six, and twelve months after surgery. FSH, LH and E2 were higher, and T and DHEA-S were lower in perimenopausal women. Prior studies from our laboratory have demonstrated the potent wound healing and anti-inflammatory effects of Tbeta-4 in numerous models of corneal injury. Rectal and bladder dose reduction with the addition of intravaginal balloons to vaginal packing in intracavitary brachytherapy for cervical cancer. The development of eimerian infections during the first eight months of life in unweaned beef calves in a dry tropical region of Australia. Implications for Rehabilitation Accurate measurement of change in gross motor skill acquisition is important to determine effectiveness of intervention programs in children with cerebral palsy (CP). The stoma is circular, uniform in size and is fitted easily with an appliance.

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To evaluate the functional effects of transforming growth factor beta1 (TGFbeta1), interleukin-1beta (IL-1beta), and oncostatin M (OSM) on the frictional properties of articular cartilage and to determine the role of cytokine-mediated changes in cartilage frictional properties by extracting and redepositing lubricin on the surface of cartilage explants. This study was designed to explore and compare the cardio protective role of regular human insulin (RHI), aspart and lispro insulin in type II DM. The oncogene DJ-1 has been associated with multiple cancers, including prostate cancer, where it can be stabilized by androgens and antiandrogens. Pulsed methylprednisolone is a safe and effective treatment for diabetic amyotrophy. Using molecular cloning techniques we exchanged sequences NH2- or COOH-terminally flanking the hydrophobic signal sequence.

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Polo-like kinase 1 (Plk1) is overexpressed in tumor tissues and its expression level is tightly associated with the malignancy of tumors and prognosis of tumor patients. Injection of Orbital Angular Momentum and Storage of Quantized Vortices in Polariton Superfluids. In both methods the presence of lectin-binding sites in the tissue sections is revealed by the appearance of a red coloration that is due to the accumulation of gold particles. Patients receiving standard therapy showed decreased NF-kappaB activity, eNO concentration and sputum levels of TNFalpha, IL6 and IL8, as well as increased TAS during recovery of ECOPD, but HDAC activity did not change. Two patients are presented in whom claudication was the only early presenting symptom. Instead, the bacteria were grouped according to principal component analysis (PCA) based on the relative amounts of volatiles emitted. Resting pain, pain on hip flexion, and walking were measured during daily physiotherapy sessions on a verbal five-point rating scale during the first allegra children dose four postoperative days.

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The aim of this prospective study is to evaluate the new dosing strategy by monitoring patients for unbound cefuroxime plasma concentrations during CABG surgery with cardiopulmonary bypass (CPB). Elevated laminin levels were associated with a progressive course of the tumor condition. Maternal recasts and activity variations: a comparison of mother-child dyads involving children with and without SLI. Expressions of PPARgamma and retinoid acid receptor (RXRalpha) were examined by reverse-transcription polymerase chain reaction (RT-PCR) with immunocytochemical staining. After discontinuation of corticosteroids, they were treated with non-steroid anti-inflammatory drugs and/or anti-thrombocyte drugs to the end of the study. The computer was programmed with physical properties of the materials as derived from the literature, and a 100-N vertical load was used to simulate the occlusal force. Early metoprolol administration before coronary reperfusion results in increased myocardial loba floxin antibiotic salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance. In agreement with this observation, a significant portion of a GFP fusion of MAGI-1b localizes to the basolateral membrane of polarized MDCK cells. An additional 5 trials compared different antimicrobial therapies but did not include placebo groups.

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Functional outcome and quality of life after angiography and operation for unruptured intracranial aneurysms. We therefore examined the frequencies of single nucleotide polymorphisms (SNPs) in 186 SALS patients and 186 controls at the allele, genotype, and haplotype levels for the metallothionein (MT) family of genes, metal transcription factor-1 (MTF-1), and glutathione synthetase (GSS). Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. These antibodies influence the specific immunological functions of the cloned T cells, suggesting that these antibodies react with the T cell receptor for antigen. Apigenin inhibits pancreatic stellate cell activity in pancreatitis. Paraquat, a prooxidant widely used in stress tests, had a strong anorexigenic effect. Quantum entropy dynamics for chaotic systems beyond the classical limit. Favorable prognostic factors included the development of recurrent carcinoma following radiation therapy and a tumor initially classified as stage I or II, irrespective of the initial mode of therapy.

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