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Capegard (Capecitabine)
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Capegard

Capegard is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Valtrex, Anafranil, Levitra, Alprostadil, Exelon, Prandin, Mobic, Persantine

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capegard for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capegard for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capegard dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capegard are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Capegard if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capegard is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capegard .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capegard and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capegard, and for at least 2 weeks after your last dose.

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Many studies have shown that certain pathologic features correlate with risk of recurrence, development of nodal and distant metastases, long term survival and multicentricity of breast carcinoma. Coalition of trapezoid, capitate, and metacarpal: a case report. A significant amount of the release of BisGMA as well as TEGDMA was seen from both the composites when stored for different time intervals. Comparative assessment of arterial pressure and of the frequency of heart contractions of neonates in cesarean section under endotracheal and local anesthesia. Respondents with stable or progressive cognitive impairment (CI) after the first (index) indication of CIND in 2000-2010 were identified from the Health and Retirement Study (HRS). Anatomical study and clinical relevance of the flexor superficialis synovial flap: an assessment of 31 hand dissections. Urologists recommend digital rectal examination and a PSA blood test annually starting at age 50.

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However, a substantial body of biochemical work has demonstrated the ability of NPR-C to couple to inhibitory G proteins (Gi) and cause inhibition of adenylyl cyclase and activation of phospholipase-C. The aptamers selectively bind to pepocin with dissociation constants between 20 and 30 nM and inhibit the N-glycosidase activity of pepocin on rat liver 28 S rRNA. Outcome measures included Snellen best-corrected visual acuity (BCVA), ocular surface stability, SI exposure, and complications. These data indicate for the first time that Ripply1 expression is regulated at the protein level. Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data.

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Report of the Executive Board of the American Public Health Association to the Governing Council, 1946-1947. Currently, the accelerator is under commissioning, while the injector linac has been completed. We investigated the short-range orientational order using a recently developed classification method and we found that both phases behave in a very similar way. The septal area is part of the limbic system and aplasia of the septum pellucidum could indicate developmental anomalies of the limbic system. To gain insight into the extrapituitary expression of Gnrhr, a transgenic mouse model that expresses the human placental alkaline phosphatase reporter gene driven by the rat Gnrhr promoter was created. Likely maternal imprinting was observed at 2q23, and possible maternal imprinting at 3q28. Verbal fluency and awareness of functional deficits in early-stage dementia. In particular, higher expression levels of the proteins, C10orf58, FLNC, PDLIM1, TPM4, and lower expression levels of MYH10, PSIP1, SYNM, SLC9A3R2, BCAM, were verified by qPCR in the U251 cell line versus the U87 cell line. The present case demonstrates the successful management of 2 challenging anatomical issues, the rigid cage of the MMV and the low-lying left main coronary ostium (LMCO), with the implantation of the ACURATE-TA bioprosthesis (Symetis SA, Ecublens, Switzerland). Considerations on the surgical treatment of Duct Carcinoma in Situ (DCIS) of the breast from DRG system perspective.

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Based on the observational study design, a causal relationship cannot be proven, and respective limitations need to be considered. These include subtractive hybridization (SH), differential colony hybridization (DCH) and mRNA differential display, all based on the analysis of mRNA. (v) What types of SLEs are available in audiology and their level of fidelity?. Most VFCs had a wide range of results at initial intake to rehabilitation, while all patients had significant visual impairment by 24 months after initial diagnosis. The aim of this study was to define the involvement of thyroid hormones, MDA and SOD levels and to establish MDA levels as an index of lipid peroxidation in women with spontaneous abortion by comparing the results with healthy pregnant females as controls. We created a three-dimensional multiple-source computer model to simultaneously visualize and analyze all the structures within the female pelvic floor. During operation of the device, cells are positioned in the designed positions. We continue the previously described prospective cohort study of ritonovir-boosted lopinavir (LPV/r) monotherapy for second-line therapy in HIV-infected patients with prior failure and extensive resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), with the objective being to determine the three-year treatment responses.

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Mean HOMA-IR was statistically greater in the VLAF and LAF when compared to MAF. Among Asian immigrants, participants reported experiencing institutional and personally mediated overt types of discrimination, including lack of access to quality and readily available translation services. Many battery systems have been developed for different AIMD applications. Among subjects with lifetime occupational histories, there were no significant increases or trends for cumulative or average EE or sitting time. Subsequently, there is increasing focus on the impact of abdominal disease on quality of life and survival. They can be broadly divided into three categories according to the spatial scale they purport to describe: the molecular, the cellular and the tissue scales. Significance of the allergic factor in the pathogenesis of pancreatitis. Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity.

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Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain. Non-homologous end joining (NHEJ) DSBs repair was involved in the DSBs repair process, as indicated by p-DNA-PKcs staining. Acupuncture was not shown to be superior to placebo acupuncture when used in conjunction with bracing for patients with mild to moderate CTS. The capabilities of the UFRD method are demonstrated using the binding of 2,4-dinitrophenol (DNP) to transthyretin (TTR), as well as preliminary measurements in several other systems. Accordingly, the mean ApEn decreased with statistical significance during arousal elicitation and the DLE became negative. The occluded coronary artery also can be reopened by percutaneous transluminal coronary angioplasty (PTCA). Factor analysis demonstrated that evaluation of a system of parameter intercorrelations in the distribution of blood cells by their volume allows pregnancy phases to be clearly differentiated. Antiviral therapy may be beneficial in eyes with detectable viral DNA. Palliative Care Consultations in Nursing Homes and End-of-Life Hospitalizations. Serum progesterone concentration was 0.67 ng/ml, which is below the threshold considered adequate for pregnancy maintenance in the mare.

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Proprio-tactile integration for kinesthetic perception: an fMRI study. We suggest that these atypical features of subacute CA and the changes in LEMS may be associated with a balance between the amount of serum anti-P/Q-type VGCC antibodies and the susceptibility of the cerebellum and presynaptic nerve terminals to the antibodies. In addition, the mouse BMP-15 proprotein is not processed into the functional mature protein in transfected cells. Cognitive symptoms and disease severity are strongly associated with need for accommodations, however accommodations do not appear to promote job satisfaction or longevity. We found supra-additive interactions between employment level and psychosocial environment, assessed by the ERI (E/R and OC).

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Regression models for analyzing radiological visual grading studies--an empirical comparison. Circatidal activity rhythm in the mangrove cricket Apteronemobius asahinai. Finally, U251-P10 cells showed resistance against curcumin treatment. Four oral isolates of these two species showed similarly high infectivities and three had moderate infectivities. The data were analysed under the population approach using NONMEM version V software. Glomerular filtration rate (GFR) was estimated by an abbreviated Modification of Diet in Renal Disease formula. A retrospective analysis risperdal medication mg of all PMBC cases reported in the SEER database between 1973 and 2002 was conducted. The authors describe a case of successful percutaneous balloon mitral valvuloplasty in a patient with severe mitral stenosis and pulmonary hypertension. Interpersonal choice: The advantage on the left or on the right?. Smoking is the leading cause of preventable death in the USA, but quit attempts result in withdrawal-induced cognitive dysfunction and predicts relapse.

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This study demonstrates that IRAP treatment administered during acute phase of cartilage impact injury increases expression levels of miR-140, miR-125b, and miR-27b in cartilage, indicating increased inhibition of their respective matrix-degrading enzymes. PDID database is freely available at http://biomine.ece.ualberta.ca/PDID/. Rate of SSI and PJI was compared between perforation and non-perforation groups, including 1226 series and flagyl dosage bv 183 case-control subset. The frequency of apoptotic bodies (mean percentage calculated from 200 cells/high-power field over 10 fields) was examined on immunostain. Cadmium Ion Adsorption Controls the Growth of CdS Nanoparticles on Layered Montmorillonite and Calumit Surfaces. A before-after design study of the effects of educational intervention comprising distribution of a brochure and one-to-one discussion with a GP. The FlaH crystal structure reveals a RecA/Rad51 family fold with an ATP bound on a conserved and exposed surface, which presumably forms an oligomerization interface. Mean operative time was 153.4 minutes, mean blood loss of 46 mL. FACS analysis showed that the binding of anti-CD14 antibodies to the macrophages was suppressed by AFB(1)-pretreatment followed by LPS-stimulation.

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Significance of mitochondrial calcium and nitric oxide for apoptosis of human breast cancer cells induced by tamoxifen and etoposide. These findings showed that pep61 may contribute to the modification of the host immune responses in the course of BLV infection. In a multilayered structure of absorptive optical recording media, continuous-wave laser operation is highly disadvantageous due to heavy beam extinction. Glucomannans (GM) are polymers that can be found in natural resources, such as tubers, bulbs, roots, and both hard- and softwoods. This is a guide and, as such, is not meant to replace clinical judgment. These results indicate that animals can equally assimilate both inorganic and organic naturally occurring selenocompounds except trimethylselenonium ion, which is the urinary metabolite of excess Se.

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This study presents a new concept of osteosynthesis of complex calcaneal fractures in combination with an alternative augmentation technique. One patient died of septic shock 23 hours after admission (four days after injury), the others survived. The establishment of a new compensation program might be key to finding a lasting resolution. Repeated word generation in response to visual cues was correlated with anatomically selective reductions in activity within the left frontal cortex along the inferior frontal gyrus and inferior temporal regions and, to a lesser degree, in specific earlier visual regions. A comprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. Additionally, dsRNA interference was utilized to examine the functional role of FcTetraspanin-3 in response to WSSV infection, and a sensible decrease of the viral copy number in the tetraspanin knockdown shrimp. Blastomogenic substances in the human environment and certain mechanisms of the origin of cancer. By using desorption measurements in combination with high-resolution scanning tunneling microscopy, we show that individual, isolated Pd atoms in a Cu surface substantially lower the energy barrier to both hydrogen uptake on and subsequent desorption from the Cu metal surface. The presence of waterborne enteric pathogens in municipal water supplies contributes risk to public health.

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Fast tools for calculation of atomic charges well suited for drug design. D- urispas 200 mg tablet FEN is a safe serotonergic probe and PRL responsivity to D-FEN is a reliable index of central 5HT function in the elderly. GATA6 is overexpressed in breast cancer and promotes breast cancer cell epithelial-mesenchymal transition by upregulating slug expression. Yet, it has been scarcely reported and is rarely considered in the differential diagnosis of HIV associated cutaneous lesions in Africa. Comparison of ligand-based and receptor-based virtual screening of HIV entry inhibitors for the CXCR4 and CCR5 receptors using 3D ligand shape matching and ligand-receptor docking. Causes of poor performance of horses during training, racing, or showing: 348 cases (1992-1996). We also assessed whether proprioceptive localization in these different tasks is affected by localization from memory, the hand-target being localized (left or right) or the movement path of the proprioceptive target (9 paths, derived from combinations of starting and final hand-target positions). Autophagy was studied using electron microscopy, the acridine orange staining method, and GFP-LC3 was examined with fluorescence microscopy.

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We analysed 31 consecutive patients retrospectively in whom flat- norfloxacin all brand name detector computed tomography was used to visualise the cavopulmonary connection. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy. MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6CloTLR2hi but Not by Ly6ChiTLR2hi Monocytes during Trypanosoma cruzi Infection. In the last decade, new data regarding macrophages and dendritic cells and the high therapeutic success of anti-tumor necrosis factor alpha biologics led to the assumption that antigen-presenting cells are important not only in the induction of psoriasis but also in its maintenance. Finally, the future challenges in heart failure modeling and simulation will be discussed. Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.

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The waveform of first-order and second-order kernel responses of m-ERG in the area of retinal artery occlusion were compared with those of the vertically symmetrical, normally perfused area of the same eye. Some data on the functional state of the hypothalamus in patients with early cerebral arteriosclerosis. Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Chemical shift perturbation mapping firmly establishes a similar mode of pKID binding to the longer KIX construct and rules out any additional intermolecular interactions between residues in the C-terminal extension and pKID. Incomplete understanding of mechanisms culminating in IDR occurrence represents a monumental impediment toward their abrogation. Orbital and intracranial effects of microgravity: findings at 3-T MR imaging.

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