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Cardzaar (Losartan)

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Cardzaar is hypotension medication which specifically blocks angiotensin II receptors, decreases the total peripheral resistance, concentration of aldosteron in blood, arterial pressure, pressure in pulmonary circulation, and has a diuretic effect. The medication is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy.

Other names for this medication:
Angizaar, Anreb, Arapres, Biortan, Czartan, Fortzaar, Gitox, Insaar, Lepitrin, Lifezar, Loben, Losadrac, Losagen, Losakind, Losalet, Losapot, Losardil, Losargamma, Losartan, Losartec, Losartil, Lospre, Lostan, Lozar, Nefrotal, Ocsaar, Osartil, Ozarium, Portiron, Ranlozar, Rasoltan, Repace, Stadazar, Tensaar

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Also known as: Losartan


Cardzaar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardzaar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardzaar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardzaar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardzaar 25 mg, Cardzaar 50 mg, and Cardzaar 100 mg may also contain carnauba wax.


Take Cardzaar tablets orally with or without food. Do not crush or chew it. Take Cardzaar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cardzaar suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardzaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardzaar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardzaar. Correct volume or salt depletion prior to administration of Cardzaar.

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Knockdown of Syncytin-A demonstrated a functional regulation of cell-cell fusion, where knockdown of Peg10 showed no involvement in cell fusion. LV trabeculated volume is more pronounced in young subjects and declines with age. Detoxification of Jatropha curcas kernel cake by a novel Streptomyces fimicarius strain. Functional maturation of membrane potential changes and superoxide-producing capacity during differentiation of human granulocytes. The goal of this study was to discuss the clinical and histologic similarities between PMPD and cutaneous melanoma and how to differentiate between the two diseases. S1 gene sequence heterogeneity of a pathogenic infectious bronchitis virus strain and its embryo-passaged, attenuated derivatives.

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Pathways from education to fertility decline: a multi-site comparative study. Oral risedronate sodium improves bone mineral density in non-ambulatory patients: a randomized, double-blind, placebo controlled trial. We determined the reporting rate of the following ethnic minority groups in studies that enrolled American patients: whites, African Americans, Asians, and Hispanics. Aqueous dispersions of magnetite nanoparticles complexed with copolyether dispersants: experiments and theory. Investigations are based on the species-specific endplate pattern of the plantaris muscle: multiply innervated fibres in the chick and focally innervated fibres in the quail. No medication is currently approved for the treatment of cocaine dependence, but several preclinical and clinical reports suggest agonist-like medications, e.g., amphetamine analogues, may be a productive strategy for medication development.

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PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling. The available literature included only blind epidural injections without fluoroscopy. A sex difference on mental-rotation tasks has been demonstrated repeatedly, but not in children less than 4 years of age. The patient had an excellent clinical response to corticosteroid therapy with minimal evidence of hyperenhancement (focal fibrosis) on cardiac MRI at 6 months. Two ribozymes, hammerhead ribozyme and hairpin ribozyme, and a DNA-enzyme were designed to cleave a same RNA target, the same site of the rat complement regulatory factor 512 antigen mRNA. Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice. These poor results emphasize the need to intensify loco-regional therapy with a concurrent cisplatin-based chemotherapy within the framework of a multidisciplinary approach. Synthesis and immunocytochemical localization of alpha 2u globulin in the duct cells of the rat submaxillary gland. Given the potentially deleterious effects of Th17 cells, their generation needs to be strictly controlled. The touch was either standard Gold-mann applanation tonometry or corneal reflex testing using a cotton-tipped applicator.

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More generally, we argue that if we measure the stimulus intensity on the scale which is proportional to the perception intensity, an improved adjustment in the coding accuracy is revealed. Diplomonad flagellates infect a wide range of fish hosts in aquaculture and in the wild in North America, Asia and Europe. Factors predicting hospital length-of-stay after radical prostatectomy: a population-based study. Transgenic lines of potato (Solanum tuberosum L.) expressing the clinically useful protein bovine aprotinin or the cysteine protease inhibitor corn cystatin II were generated by Agrobacterium tumefaciens-mediated transformation, and then used as test material for the analyses. The aim of this review is to introduce and present current data regarding the effectiveness of a range of technology tools to promote vaccination, describe gaps in the literature and offer insights into future directions for research and intervention. To examine the association between use of health care services and health status, sociodemographic, and health care system characteristics in children and adolescents from 11 European countries.

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To determine whether a single T cell recognizes the antigen in the context of both Ia molecules or in the context of each one of two Ia molecules, we isolated and propagated PPD-reactive T cell clones from an HLA-DR heterozygous individual. Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. Strontium-based glass polyalkenoate cements for luting applications in the skeleton. Poor effort was observed in the athletic population during baseline testing and athletes with poor effort displayed statistically significant differences in performance on neuropsychological tests. NSAIDs, coxibs and steroids used alone or in association have been demonstrated to be effective for relieving postoperative pain. Identification and characterization of wild lactobacilli and pediococci from spontaneously fermented Mountain cheese. Hormonal factors are implicated in tumor progression and it is possible that factors influencing breast cancer induction could affect prognosis. The effects of proteins on the xanthene triplet state and its precursor were observed by time-resolved 530 nm photolysis. Approximately half these patients will be cured with aggressive irradiation alone or combined with surgery.

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Eligible patients with previously untreated mCRC are randomized 1:1 to either is it safe to take klonopin while breastfeeding mFOLFOX-6 combined with bevacizumab and placebo followed by 5-fluorouracil/leucovorin plus bevacizumab and placebo or mFOLFOX6, bevacizumab plus MetMAb followed by 5 FU/LV, bevacizumab, and MetMAb. The antibody against GTase-R inhibited the glucan-synthesizing activities of Streptococcus gordonii and Streptococcus sanguis, as well as S. Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital. The psychometric properties of this user friendly survey demonstrate consistently good scalability. Preliminary results of carotid artery stenting in a non-academic hospital. Highly sensitive assay for alkaline and acid phosphatase activities by high-performance liquid chromatography with electrochemical detection. This procedure is seldom performed in developing countries due to limited equipment and expertise.

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Peripheral blood mononuclear cells isolated by gradient centrifugation were incubated in the presence of daunorubicin (a fluorescent drug extruded by P-glycoprotein) at 37 generic zyrtec non drowsy degrees C or 4 degrees C for 30 min. In contrast, PBMNCs from all other individuals supported infection in vitro by both CCR5- and CXCR4-using HIV-1 strains. Preliminary investigations of several crude plant extracts including aqueous extract of Benincasa hispida Cogniaux exhibit anti-inflammatory properties. Extracts of submandibular gland and blood did, however, produce parallel competition curves. To investigate the influence of social network characteristics on subjective well-being over 6 years in a population sample of older adults. In the aim of protecting stainless steel surfaces against protein and/or bacterial adhesion, thin films including the glycosidase hen egg white lysozyme (HEWL) and/or the synthetic polymer poly(ethylene glycol) (PEG) were covalently coated onto flat substrates by wet chemical processes. Institutional review board-approved retrospective case-control study. The implications of these results in terms of chemotherapy are discussed. Description and morphometric variability of Paranoplocephala serrata n.

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Vibrato, a small, nevertheless an important component in the singing voice is known to enrich the overall singing voice quality. Post-traumatic subdural hygroma: diagnostic conditions and sporanox cost therapeutic attitude in Gabon. The role of bacterial lipopolysaccharide (endotoxin) and induction of locally synthesized proinflammatory cytokins in pathogenisis of diarrhea are discussed. The appliance must function not only initially but also for many years to come. Transition to adult urologic care is critically important as these patients mature and the goals of care shift to include sexual function, fertility, and reconstruction. Fluctuations mainly in the sex hormone progesterone, in plasma and endometrium tissue, could interfere with ER and PgR levels.

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Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer. There was marked reduction of the amplitude of P-V and P-III and deformation of the single components of the potential with widening and smoothing. Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. Prevention of ischemic heart diseases initiated during childhood. With the coming of steam drifters in 1900 trawling for white fish became how long do i have to wait to drink alcohol after flagyl easier and they substituted for the herring and the taste for herring has been lost. This and other suggestions for annotation of 4-epimerase genes will facilitate annotation.

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The depth of the cavities was judged from radiographs and clinically into outer, middle and inner third of dentine. Structural investigation of the proton-coupled secondary transporters. However, spottings or bleedings most often occur at the beginning of treatment. Multiple logistic regression analysis was conducted to determine the odds of subsequent pregnancy within 6 months of first birth. The use of platelet-rich plasma (PRP) alone in periodontal defects has been controversial and inconclusive. We purified the recombinant dextransucrase by using ammonium sulfate precipitation and metal chelate affinity chromatography on a Ni-NTA column. Further research is needed to clarify the nature of the association and suggest ways to get high-risk women into care sooner.

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High-fat diet-induced obesity stimulates ketone body utilization in osteoclasts of the mouse bone. vaginalis epidemiology and raises concern about the impact of HIV transmission and female reproductive health. While habitual distraction predicted better mood outcomes across all conditions, patients high in habitual mindfulness tended to show stronger negative mood reduction specifically ramipril brand or generic after the induction of a mindful self-focus. Electromyographic recordings were made of the sequence of actions of each muscle and of the combined muscle activity, at rest and during swallowing of food. The expression levels of MAP4K5, E-cadherin, vimentin, and carboxylesterase 2 (CES2) were examined by immunohistochemistry in 105 PDAC and matched non-neoplastic pancreas samples from our institution. A multichannel scaling (MCS) system has been developed to monitor the biological distribution of radiotracers in vivo. Etomidate use for critically ill patients should consider all of these issues and not simply the possibility of adrenal suppression, which may not be important when steroid supplements are used. In electron microscopy, scattered filaments, 10-11 nm in diameter, were seen in detergent-extracted cleavage-stage embryos.

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Fever after TACE is common, but infectious complications are rare. Writing for publication can be a daunting experience for the novice and experienced researcher. Practical approach to electrodiagnosis of the carpal tunnel syndrome: A review. An important part of the sample held negative attitudes especially concerning social discrimination and restriction of the patients. Callosal neurons were found in every retinotopically defined cortical area. chronic HBV-infected patients were nearly 3 times more likely to develop NHL than comparison patients. Furthermore, a mismatch (G:T) within the probe-targeted region of the HSV-2 glycoprotein B gene decreases the probe/product melting temperature (Tm) from 69 degrees C for HSV-1 to 64 degrees C for HSV-2, enabling the simultaneous identification of the two HSV genotypes by melting-curve analysis within one run. This allows for cytologic studies of host cells, morphology of the amebae present, and specific immune marking of the amebae by use of immune sera and protein A Staphylococcus. Arterial stenosis and spasm precluded such treatment in one patient.

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The present findings indicate that BDNF could protect a large number of neurons in cerebral cortex and hippocampus from inflammatory brain injury in bacterial meningitis. An observational, prospective study was conducted among patients with exacerbation of moderate or severe COPD. cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. We investigated costs of three virulence factors in Puccinia striiformis f.sp.tritici, a fungal pathogen of wheat (Triticum aestivum). District directors are co-responsible for the organizational profile. The recent studies show that several skeletal system diseases are related to pre-mRNA splicing. The sample consisted of 8871 individuals residing in 226 neighbourhoods from five urban regions.

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Together, these data suggest that specific localization and compartmentalization of proteins in the epididymosomes coordinate the association of epididymal proteins with the different functional structures of spermatozoa. The reconstruction is challenging and tedious and requires meticulous execution for success. We identified 12 phosphopeptides for which the abundance changed upon HR initiation, as compared to control seedlings. Healthcare for all in emerging countries: a preliminary investigation of facilities in Kolkata, India. High-resolution transmission electron microscopy of inorganic materials in cellular and topological random systems. Medical records of patients who underwent buckle explantation from July 2007 to May 2012 were reviewed retrospectively.

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Maximal de-N-glycosylation was achieved when serum was subjected to reductive alkylation in the presence of 2-hydroxyl-3-sulfopropyl dodecanoate, a surfactant used for solubilizing proteins, or related analogues, followed by tryptic digestion prior to PNGase F treatment. Cardiac and peripheral vascular responses to adrenoceptor stimulation and blockade after cardiac transplantation. The most relevant phenotypic features seen in both proximal and distal partial trisomy 13 have been identified from a review of 35 cases. An HL-7702 cell line stably expressing the HBx gene by lentivirus vectors was constructed. There have also been reports of the organism developing resistance to trimethoprim-sulfamethoxazole (TMP-SMX), which was initially considered as the drug of choice for S. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals.

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Loss of heterozygosity (LOH) and homozygous deletions at chromosome 3p21.3 are common in both small and nonsmall cell lung cancers, indicating the likely presence of tumor suppressor genes (TSGs). In this paper, we propose a dynamic clustering method based on EEG to estimate vigilance states. Dimethoate, representing organophosphorus compounds, was the only insecticide tested to inhibit the N-demethylation of DMN, with more pronounced effect on DMN demethylase I. Long-term rebamipide and diquafosol in two cases of immune-mediated dry eye. Many of the clinical manifestations and imaging findings were indistinguishable from those of cavernous hemangiomas, solitary fibrous tumors, neurofibromas, and other variants of meningiomas. They can adsorb methylene blue with high efficiency, with adsorption capacity increasing from 263 to 1977 mg/g as the initial concentration increases from 5 to 300 mg/L. In contrast, mice pretreated with CoCl2, a calcium channel inhibitor, and/or adrenalectomized mice, showed no discernible changes in the lymphoid tissues after repeated injections of maitotoxin.

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The aim of the study was to investigate the impact of V(2)O(5) on DNA stability in workers from a V(2)O(5) factory. Very different values of specific optical rotations were measured in both trans and cis isomers, also reflecting the existence of distinct chiral entities in the photostationary states. A lesser contribution was derived from the glutamine and alanine residues at positions 149 and 152, respectively. Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Large-scale genetic interaction studies provide the basis for defining gene function and pathway architecture. Diagnosis is not simple and requires a synoptic approach using several investigations. In the majority of cases, however, one of the interacting proteins was known to be involved in DNA replication, transcription, virion structure, or host evasion, thereby providing a clue to the role of the other uncharacterized protein in a specific process. We also highlight the interactions of lipids and proteins during the process of translocation and integrate this into a model that enables us to understand the role of membrane lipid composition in translocase function. Also, it was demonstrated that the amount of hydrogen peroxide in the treated samples was higher than the control samples with no herbicidal treatment.

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