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Cardzaar (Losartan)
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Cardzaar

Cardzaar is hypotension medication which specifically blocks angiotensin II receptors, decreases the total peripheral resistance, concentration of aldosteron in blood, arterial pressure, pressure in pulmonary circulation, and has a diuretic effect. The medication is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy.

Other names for this medication:
Angizaar, Anreb, Arapres, Biortan, Czartan, Fortzaar, Gitox, Insaar, Lepitrin, Lifezar, Loben, Losadrac, Losagen, Losakind, Losalet, Losapot, Losardil, Losargamma, Losartan, Losartec, Losartil, Lospre, Lostan, Lozar, Nefrotal, Ocsaar, Osartil, Ozarium, Portiron, Ranlozar, Rasoltan, Repace, Stadazar, Tensaar

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Also known as: Losartan

Description

Cardzaar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardzaar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardzaar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardzaar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardzaar 25 mg, Cardzaar 50 mg, and Cardzaar 100 mg may also contain carnauba wax.

Dosage

Take Cardzaar tablets orally with or without food. Do not crush or chew it. Take Cardzaar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cardzaar suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardzaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardzaar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardzaar. Correct volume or salt depletion prior to administration of Cardzaar.

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To determine whether a single T cell recognizes the antigen in the context of both Ia molecules or in the context of each one of two Ia molecules, we isolated and propagated PPD-reactive T cell clones from an HLA-DR heterozygous individual. Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. Strontium-based glass polyalkenoate cements for luting applications in the skeleton. Poor effort was observed in the athletic population during baseline testing and athletes with poor effort displayed statistically significant differences in performance on neuropsychological tests. NSAIDs, coxibs and steroids used alone or in association have been demonstrated to be effective for relieving postoperative pain. Identification and characterization of wild lactobacilli and pediococci from spontaneously fermented Mountain cheese. Hormonal factors are implicated in tumor progression and it is possible that factors influencing breast cancer induction could affect prognosis. The effects of proteins on the xanthene triplet state and its precursor were observed by time-resolved 530 nm photolysis. Approximately half these patients will be cured with aggressive irradiation alone or combined with surgery.

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