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Crestor (Rosuvastatin)
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Crestor

Crestor is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used together with dietary changes, exercise, and weight loss. It is taken by mouth.

Other names for this medication:
Creston, Dorosur, Liparon, Provisacor, Richstatin, Rosumed, Rosuva, Rosuvas, Rosuvast, Rosuvastatin, Rosuvastatina, Rosuvastatinum, Rosuvastin, Rovartal, Rovast, Rozavel, Simestat, Sinlip, Turbovas, Visacor, Zyrova

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Also known as: Rosuvastatin

Description

{name} (rosuvastatin) belongs to a a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

{name} is used in adults and children who are at least 8 years old to lower cholesterol and triglycerides in the blood.

{name} is used in adults to slow the progression of atherosclerosis (a build-up of plaque in blood vessels that can block blood flow).

{name} is used to lower the risk of stroke, heart attack, and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors.

{name} is also used to treat hereditary forms of high cholesterol, including the heterozygous type (inherited from one parent) and the homozygous type (inherited from both parents). For the heterozygous type, {name} can be used in children who are at least 8 years old. For the homozygous type, this medicine can be used in children as young as 7 years old.

Dosage

Usual Adult Dose for Hyperlipoproteinemia:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IIa (Elevated LDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Atherosclerosis:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Homozygous Familial Hypercholesterolemia:

Initial dose: 20 mg once a day with or without food Maintenance dose: 20 mg to 40 mg once a day with or without food

Usual Adult Dose for Prevention of Cardiovascular Disease:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food Response to therapy should be estimated from preapheresis LDL-C levels.

Usual Geriatric Dose for Hyperlipidemia:

Initial dose: 5 mg once a day with or without food Maintenance dose: 5 mg to 20 mg once a day with or without food

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:

Pediatric patients 10 to 17 years of age: Usual dose range: 5 to 20 mg orally once a day with or without food. Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more. Maximum dose: 20 mg orally once a day

Detailed Crestor dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Crestor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Crestor if you are allergic to rosuvastatin, or if you have:

liver disease/high levels of liver enzymes in your blood; or if you are pregnant or breastfeeding.

Do not take Crestor if you are pregnant. Rosuvastatin could harm the unborn baby or cause birth defects. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking this medicine.

To make sure Crestor is safe for you, tell your doctor if you have ever had:

liver problems; kidney disease; a thyroid disorder; a habit of drinking more than 2 alcoholic beverages per day; if you are of Asian descent; or if you are 65 or older.

Crestor can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

People of Asian descent may absorb rosuvastatin at a higher rate than other people which may cause muscle weakness/dysfunction. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose.

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Changes in weight after traumatic brain injury in adult patients: a longitudinal study. Recent studies on mixed substrate utilization in both batch and continuous cultures have thrown light on the strategies of the control mechanisms that, in microbes, govern the utilization of the various substrates. Because the literature offered no guidelines for interpreting our data, we used criteria from other studies to interpret the results. Two new series of aryl SMAMPs (synthetic mimics of antimicrobial peptides) with facially amphiphilic (FA) and disrupted amphiphilic (DA) topologies were designed and synthesized to directly assess the role of amphiphilicity on their antimicrobial activity against gram-positive and gram-negative bacteria in closely related structures. Data collected included sociodemographic characteristics, sexual behaviors, and drug use patterns.

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Differential over-expression of EPOR and EPO in benign and malignant prostatic tissue is ascribed to different mechanisms involved in up-regulation between EPO and EPOR. In contrast to morphologically malignant intraductal lesions that represent earlier stages of the malignant process in other anatomic sites such as the breast, IDC-P has now been generally recognized as a prognostically unfavorable manifestation of later stage spreading of its invasive counterpart. TRAP is itself regulated by the protein Anti-TRAP, which binds to TRAP and prevents RNA binding. Thus the conducting pulmonary arteries, like the peripheral resistance arteries, adapt structurally to extrauterine life. Biplanar chevron osteotomy has previously been described to correct the deformity in two planes. Earlier this century, suggestive clinical evidence for a colour centre in the brain of man was dismissed because of the association of other visual defects with the defects in colour vision. how much are tamoxifen tablets

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Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells. The production of five prostanoids (PGD2, PGE2, PGF2 alpha, 6-oxo-PGF1 alpha, and TxB2) was examined after mast cell activation. Two general pathways for siderophore biosynthesis exist: the well-characterized nonribosomal peptide synthetase (NRPS)-dependent pathway and the NRPS-independent siderophore (NIS) pathway, which relies on a different family of sparsely investigated synthetases. Ability of mutant bacteria to move through soil to infect roots was tested by planting wounded seedlings into air-dried soil or sand that had been infested with inoculum. Echovirus type 9 is an important cause of viral encephalitis among infants and young children in Kuwait. Usage of emergency medical services by children with special health care needs. Dopamine produced DNA fragments (demonstrated by TUNEL method) and induced degradation of cytokeratin by activated caspase in HSG cells (detected by an immunocytochemical method, using a specific M30 monoclonal antibody). The repetitive sequencing of bacterially cloned ITS2 polymerase chain reaction amplifications generated numerous sequence variants that clustered together according to the symbiont under analysis. Comparative efficiency of obsidan, novocainamide and placebo was studied in patients with ventricular extrasystole of varying origins.

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