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Depakote (Divalproex)

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Depakote is a medication they will take for a long time or possibly their entire life. This is because it is used to treat conditions that are typically lifelong or chronic conditions. Never stop Depakote without talking with your provider first.

Other names for this medication:
Biproate, Devot, Dicorate, Diproex, Discern, Disorate, Divaa, Divalex, Divalin, Divalprid, Divalpro, Divalproex, Divalrate, Divanet, Epilex, Epival, Genval, Napilex, Navalin, Proval, Sezex, Sodijet, Spikalon, Trival, Valcort, Valcot, Valfox, Valop, Valowin, Valpex, Valporate, Valporiv, Valpret, Valprol, Valrate, Valric, Valtril, Valver, Velze, Vinchorate

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Also known as: Divalproex


Depakote is a perfect remedy in struggle against seizure disorders. Depakote acts by increasing the amount of a certain natural substance in the brain. Depakote is also known as Valproate semisodium, Divalproex sodium, Valproic acid, Divaa. It is anticonvulsant. Generic name of Depakote is Divalproex Sodium. Brand names of Depakote are Depakote, Depakote ER, Depakote Sprinkles.


This section provides information on the proper use of a number of products that contain valproic acid. It may not be specific to Depakote DR. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide or patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the delayed-release capsules or oral capsules whole with a full glass of water. Do not split, crush, or chew it. You may take this medicine with food to decrease stomach upset.

If you cannot swallow the capsule whole, you may open it and sprinkle the contents onto a small amount of soft food (including applesauce or pudding).

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, delayed-release capsules, and solution): For seizures: Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may gradually increase your dose every week by 5 to 10 mg per kg of body weight as needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken 2 or more times during the day. Children younger than 10 years of age—Use and dose must be determined by your doctor. For oral dosage form (delayed-release capsules): For mania: Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For migraine: Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg a day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Depakote are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drinking alcohol may increase certain side effects of divalproex sodium.

Avoid driving or hazardous activity until you know how Depakote Sprinkles will affect you. Your reactions could be impaired.

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Experimental composite using silver-tin alloy as filler and 4-META as coupling agent. Transient cotransfections of K562 cells with plasmid coding for the normal membrane domain of band 3, together with increasing amounts of plasmid coding for the mutated R490C membrane domain, demonstrated that the band 3 mutant polypeptide exerts a dominant negative effect on the plasma membrane targeting of the normal band 3. Allergic diseases with mast cells (MC) as main effector cells show an increased prevalence. This work may help researchers to estimate error rates and to use the estimates in their analysis to increase power and decrease bias, without the extra work of genotyping family members or replicates. The system facilitates three-dimensional delineation of the functional morphology of the urethra, requires no more time and work than does the conventional urethral pressure profile study, or causes no pain in the patient. The objective was to identify predictive factors for non-invasive ventilation (NIV) failure and to describe its use protonix ec tab in bronchiolitis. CGM users often rely on ROC information when determining insulin doses and tend to be more aggressive in their insulin adjustments despite differences in type of diabetes. An antiserum against Atlantic salmon IFNa1 detects IFN and neutralizes antiviral activity produced by poly I:C stimulated cells.

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Microcirculatory and central hemodynamic functions of hypertension patients being treated with sodium chloride baths. We enrolled five clinical nurses with interventional experience in rehabilitating patients with disorders of consciousness to sit without trunk support. In addition, MC1575 did not inhibit class I HDAC gene expression, thus confirming the specific targeting of class II enzymes. After physical exercise, beta TG rose significantly (p less than 0.05) only in the control group, thus abolishing the difference (evaluated through beta TG values) between the two groups observed at rest. Results from the stem cells in myocardial infarction (STEMMI) trial. To observe the effect of acupuncture in treating diabetic peripheral neuropathy (DPN). Detection can you drink alcohol when taking zithromax and species identification of malaria parasites by isothermal tHDA amplification directly from human blood without sample preparation. A Virtual Reality-Cycling Training System for Lower Limb Balance Improvement.

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Hypothalamic afferent connections mediating adrenocortical responses that follow hippocampal stimulation. Objective grading of facial paralysis using Local Binary Patterns in video processing. These AT secretion and folding features can potentially facilitate efficient secretion. Liver transplantation has excellent results in abstinent patients with end stage liver disease but there are concerns about recidivism after transplant. Specific strategies to facilitate theoretical research in a service setting are proposed. The robotic system is briefly described, followed by a description of a clinical trial in spinal nerve blockade. Combination of two criteria - the calculated difference between densities and the largest dimension of a lesion, increased diagnostic possibilities of radiological differentiation of granulomas and radicular cysts.

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