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Detrol (Tolterodine)
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Detrol

Detrol is used to treat overactive bladder. This medicine reduces the amount of bathroom visits. It may also help to control wetting accidents. Detrol is usually started at 2 mg by mouth two times a day.

Other names for this medication:
Bapter, Concys, Detrusitol, Dezrolala, Flochek, Roliten, Terol, Tolter, Tolterodine, Uftol, Uridin, Urotel

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Also known as: Tolterodine

Description

{name} LA is used in adults to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence (urine leakage).

Dosage

Usual Adult Dose for Urinary Incontinence:

Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency:

Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Detailed Detrol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Detrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Detrol if you are allergic to Detrol components. Do not take Detrol while you are pregnant or have nurseling. Avoid alcohol. Take Detrol with care if you are taking bepridil (Vascor),cisapride (Propulsid);chloroquine (Arelan) or halofantrine (Halfan);cyclosporine (Gengraf, Neoral, Sandimmune); narcotic medication such as levomethadyl (Orlaam); or methadone (Dolophine, Methadose);pentamidine (NebuPent, Pentam);vinblastine (Velban);antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), telithromycin (Ketek);medicines to treat psychiatric disorder, such as chlorpromazine (Thorazine), mesoridazine (Serentil) pimozide (Orap), or thioridazine (Mellaril); or heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), procainamide (Procan, Pronestyl), quinidine (Cardioquin, Quinaglute), or sotalol (Betapace), arsenic trioxide (Trisenox); haloperidol (Haldol), droperidol (Inapsine). You should be careful when you are driving or operating machinery. It can be dangerous to use Detrol if you suffer from or have a history of a blockage in your stomach or intestines, untreated or uncontrolled glaucoma, kidney disease, "Long QT syndrome", blockage of the urinary tract (difficulty urinating), liver disease. It can be dangerous to stop Detrol taking suddenly.

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Inadvertent fracture during the attempted removal of entrapped Swan-Ganz catheter. Testing was performed on standard cannulae of 20, 18, and 16 gauge caliber and also a 7.5 cm 15G Emergency Transtracheal Airway Catheter (Cook Medical). CYP27B1 and CYP24 were found in kidneys (the main location of 1,25-(OH) (2)D(3) synthesis) and also in brain cells, osteoclasts, keratinocytes, macrophages, intestine epithelial cells, and in some cancer cells. Our results suggest that the poor GagC-1V3 VLP release was attributed to the hydrophobic region in the V3 sequence of the chimeric protein, and that not only the N-terminal myristylation and positively charged domain of the Gag protein functioned as a targeting signal to direct membrane binding, but also that the C-terminal hydrophobic region affected release of chimeric VLPs. Infection with Mycobacterium avium complex in the nonimmunocompromised host.

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Phospholipid bilayers made from monolayers on patch-clamp pipettes. Findings of the complex study carried out by means of hematologic, cytochemical and immunologic methods on 130 workers engaged for the 5-year period in carbonic plastic production on the basis of methanol-containing and epoxy resins are presented. A fluorescent staining procedure based upon thioflavin T is described. The high crude mortality of invasive candidiasis remained essentially unchanged during the last two decades despite new treatment options that became available. The mitochondrial permeability transition pore (PTP) is a mega-channel modulated by calcium and ROS/RNS modifications and it has been described to play a crucial role in many pathophysiological events since prolonged channel opening causes cell death. Because CYP2E1 plays a key role in alcoholic liver disease with its ability to stimulate lipid peroxidation, we tested the proposal that CYP2E1 could also be a factor in the development of NASH. The substrate specificity for the purified nanoKAZ and the nanoKAZ secreted into the cultured medium was determined, indicating that bis-coelenterazine (bis-CTZ) and newly synthesized 6h-f-coelenterazine (6h-f-CTZ) are an efficient substrate for the glow luminescence reaction of nanoKAZ.

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The present study determined whether a diagnostic definition of PLE was routinely used in published clinical Fontan studies, and to identify potentially relevant diagnostic criteria for composing a uniform PLE definition. Endothelial damage was assessed by vital staining of corneal endothelium immediately following direct contact with an intraocular lens. By using a model DXC-300 erythrocyte deformability (ED) test apparatus, we determined the indices of filtration (IF) in 34 cases of pregnancy induced hypertension, 27 normal pregnancies and 36 healthy women as control to reflect the deformability of their erythrocyte. Thus, it seems that it is the nonionized form of local anesthetics that inhibits histamine release and that it is nonionized molecules that penetrate the mast cell membrane. At the age of 6, 16, or 25 weeks in the experimental groups, we created a soft-tissue cleft in the medial region of the palate, made relaxation incisions, and elevated and closed the mucoperiosteum in the midline, thus leaving two areas of denuded bone adjacent to the dentition. Immunomodulatory effects of domoic acid differ between in vivo and in vitro exposure in mice. Introduction of the cytosolic phospholipase A2 (cPLA2) gene to C12 cells resulted in restoration of the TNF sensitive phenotype (CPL4 cells). Comparisons between each pairing of the stratified groups also yielded statistically significant differences.

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Effect of heart rate increase on dorsal aortic flow before and after volume loading in the stage 24 chick embryo. The aim of this study was to evaluate goblet cell population and conjunctival epithelial morphology in patients with CF. In the second step, femtosecond few-cycle laser pulses are applied to the oriented system to steer vibrational dynamics, modeled by anharmonic vibrational wave functions calculated on a potential energy surface obtained with unrestricted fourth order Moller-Plesset ab initio calculations. Furthermore, peptide mapping comparisons demonstrated structural variations between the gp90 components of the various strains. Usefulness of endosonography in the etiologic diagnosis in patients with acute idiopathic pancreatitis.

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Use of regional lymphotropic injection of drugs in the differential diagnosis and complex treatment of tuberculosis in adolescents. Adverse reactions to polylactic acid injections in the periorbital area. The level of symptom bother was not different between ethnicities in women with stage 3 prolapse or greater. This is supported by Caco-2 transport studies performed when the pH of the apical medium was lowered from 7.4 to 6.0, in which a dramatic increase in permeability was observed for HR720 compared to those of the other analogues. Effects of Vipera lebetina (Turanica C.) venom on electrocardiogram of Swiss albino mice by heart rate variability technique. As results, Sp1 and p53 bind to the PrP promoter, leading to increase PrP(C) expression. The resulting membrane was characterized in terms of crystal morphology and polymorph using scanning electron microscopy and X-ray diffraction.

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The geometric and electronic structures of the complexes have been established by advanced spectroscopic methods, including resonance Raman and X-ray absorption spectroscopies, and augmented by density functional theory analyses. Evaluation of the efficacy of intervention measures and vaccination for the control of LPAI epidemics in Verona province (Veneto, Italy). Further complicating the study of PARG is the existence of multiple PARG isoforms in the cell, the lack of optimal PARG inhibitors, and the lack of viable PARG-null animals. One of the goals of total knee arthroplasty (TKA) is to balance the loads between the compartments of the knee. Postoperative intrathecal irrigation with plasminogen activator (Urokinase) after early stage operation on ruptured cerebral aneurysm.

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Protein concentration was estimated using the Bradford colorimetric assay. Three 11-d collection periods were conducted during early February, early March and early April. In vitro and in vivo results for miltefosine, amphotericin B, and the selected compound 1 have been included to validate the assay. Runoff from sweating as a function of relative humidity was introduced along with evaporation, and these results were compared to data to validate the model. The neural circuit hypothesis of Gorman still attracts attention. Many of these plants and traits have not been commercialized and represent experimental model systems. The development and use of the E75 (HER2 369-377) peptide vaccine. We also discuss surgical modifications of sphincter pharyngoplasty.

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Fifteen implants (8.5 percent) in 12 patients (11.3 percent) were either removed or repositioned. Sacral nerve root electrodiagnosis can be used in operations to identify physiologically-stimulated afferents and reflex activated motoneurons and, therefore, possibly will be useful in nerve anastomoses and nerve root stimulations in paraplegia. To investigate the relationship between acoustic signal typing and perceptual evaluation of sustained vowels produced by tracheoesophageal (TE) speakers and the use of signal typing in the clinical setting. Our previous study revealed that apomixis, recycling of tetrasporophytes, can be generated through outcrossing between genetically divergent entities of Caloglossa monosticha M. Validate an instrument to measure the Perceived Social Support in outpatients who are in treatment to hypertension and/or diabetes mellitus ii. Combination index (CI) values indicated synergistic effects of PA and the topoisomerase inhibitors. Patients scheduled for Le Fort I osteotomies and bilateral sagittal split ramus osteotomies were enrolled in the prospective, randomized, double-blind, placebo-controlled clinical study.

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Hemorrhagic ulcerated schwannoma with a double endo and exogastric localization. OK-432, an inactivated and lyophilized preparation of a low-virulence strain of Streptococcus pyogenes induced a phagocytosis process in human erythroleukemic K 562 cells. Quantitative analysis of peripheral tissue perfusion using spatiotemporal molecular dynamics. To identify the chemical mediators of the response, we determined the effects of receptor antagonists, agonist desensitization and other agents on the Isc response to EFS. The neointimal coverage of the non-apposed struts over the side branch was assessed by light microscopy. Limitation of differential expression of HLA-A,B,C antigens on choriocarcinoma cell lines by messenger RNA for HLA heavy chain but not by beta 2-microglobulin.

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We used logistic regression to estimate the association between lactate concentration in vaginal fluid and time to onset of labour. Three-dimensional (3D) models of them were generated in a homology model using the crystal structure of the marmoset SLAM and measles virus H protein complex as a template. We obtained data regarding ALS/MND type (sporadic versus familial), treatment assignment (active versus placebo), survival and ALS Functional Rating Scale scores for four large RCTs that included 822 sporadic and 41 familial ALS patients. We show that hollow microspheres with shells of 100-200 nm in thickness can be stabilized even at high pH when a strong ionic force is required to screen the negative charges. Each child underwent a sagittal T1-weighted MRI scan of at least one foot.

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Blood glucose levels, HbA1C, insulin levels, and serum omentin-1 were measured at baseline and after 12 weeks of treatment. Results of examination of the spectral characteristics of the light-adapted ERG demonstrated that the recordings represented activity of the rod system, despite the presence of a background field, which eliminates the response of the rod system in normal subjects. Hepatic artery aneurysm simulating a cystic mass of the pancreas. These observations reveal a previously unrecognized function of CaMKII as a kinase signaling to histone H3 and remodeling chromatin. Plasma glucose levels were obtained every month during a 6-month period, with a basal determination prior to protease inhibitor therapy. Multiple dose pharmacokinetics of inhaled loxapine in subjects on chronic, stable antipsychotic regimens.

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Use of immunological and molecular biological methods to diagnose cerebral toxoplasmosis in HIV infection. Moreover genital mycoplasmas have been implicated in different neonatal diseases such as pneumonia, sepsis and meningitis. Storage length, storage temperature, and lean formulation influence the shelf-life and stability of traditionally packaged ground beef. Our thesis is that it is essential to understand this process as part of the complete care given in obstetrics. However, there still exist unresolved issues in the management of dyslipidemia. In a small country such as Finland it is necessary to concentrate treatment to only a few centers, to ensure a high quality of treatment.

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After delivery there were no postnatal complications, so removal of the shunt was not considered, and clinical follow-up of the infant to the age of 12 months was uneventful. A 40-year-old man presented for diagnosis with nodules and plaques of the nose and upper lip, progessive over 1(1/2) years. Removal of any residual tissue in the prostatic fossa and removal of a wedge from the bladder neck are done with the resectoscope. In developing countries, such as China, cigarette smoking and other forms of tobacco use continue to increase. A case of anaphylaxis caused by enokitake (Flammulina velutipes) ingestion. Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinus. HIV-1-encoded TLR ligands may, therefore, directly contribute to the immune activation observed during viremic HIV-1 infection.

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We therefore sought to establish the impact of PA on QoL and reported anxiety of children with clinically confirmed PA, their parents and older siblings. Carbohydrate fermentation results in the production of SCFA which are known for their trophic and health-promoting effects. Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Compared with EMR, ESD is generally associated with higher rates of en bloc, R0, and curative resections and a lower rate of local recurrence. An indirect approach entails the increase and enhancement in utilizing widely spread media, e.g., feature films and television programs, to convey issues related to curbing risk-behavior. Although bisphenol A did not alter blastocyst morphology or cell number, early exposure to 100 microM bisphenol A increased subsequent trophoblast areas. what is the usual dose of imipramine Comparison between thymus- and spleen-derived B-cell hybridomas. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes.

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By using our potential difference approach, which is similar to modeling drawdown in confined settings, we remove the need for specifying poorly known boundary condition values and natural source/sink terms within the problem domain. A survey of a representative sample of faculty members in accredited professional (entry-level) physical therapist education programs in the United States was conducted. With the exception of one T cell clone that recognized only the HA molecule used for immunization, the clones responded to determinants that showed partial or complete cross-reactivity amongst the strain A subtypes. With enzymes chondroitinase ABC and heparinase III chondroitin/dermatan sulfate proteoglycans were shown to prevail in all components of the myoblast culture. Pre-cultivation of microvascular fragments resulted in the loss of their native vessel morphology. This was found to give safe, reliable anaesthesia when coupled with pulse oximetry and electrocardiographic (ECG) monitoring. Between June 2007 and March 2011, totally 88 patients (50 male, 38 female), referred to our Interventional Radiology Department for sonographically guided Tru-cut biopsies for liver lesions, were examined.All biopsies were performed by an experienced radiologist with an 18-gauge Tru-cut biopsy needle with a spring-loaded biopsy gun under sonographic guidance. Development and validation of a HPLC method for the determination of buprenorphine hydrochloride, naloxone hydrochloride and noroxymorphone in a tablet formulation. Periodicities occurred only in group IIa and did not correspond to weekly or monthly cycles. During gastrulation, PMCs migrate and become positioned along the ectodermal wall following a stereotypical pattern that determines skeleton morphology.

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Normal vibrational analysis of a trans-planar syndiotactic polystyrene chain. Using 1,2-dihydroxynaphthalene-4-thioacetate (1,2-NQH2-SAc) as a precursor to 1,2-dihydroxynaphthalene-4-thiol (1,2-NQH2-SH) and a generator of reactive oxygen species (ROS), we demonstrate that protein thiols viagra generic name and classification can be modified by a reactive sulfenic acid to form disulfide adducts that undergo rapid cleavage in the presence of glutathione (GSH). This review highlights recent advances in understanding the regulation of apoptosis and autophagy by ubiquitination. The case of a 78-year-old patient with cancer-related pain and additionally mixed-pain syndrome is presented. The orientation of the ilvB operon relative to plasmid genes was determined by restriction enzyme mapping. Mounier-Kuhn syndrome (MKS) is a rare congenital anomaly characterized by dilated trachea and main bronchi due to atrophy of the elastic fibers and smooth muscle cells of the trachea and major airways. Providing common tools to systematically report to the EU Commission hazardous exposures to pesticides, as well as to other selected categories of products, could allow for data comparability between Member States and greatly improve post marketing surveillance and alerting systems in Europe. However, genes involved in lipid metabolism, including hormone-sensitive lipase, were unchanged in the adipose tissue of the Cas mice, despite the increase in WAT. The Community As the Patient in Malaria-Endemic Areas: Preempting Drug Resistance with Multiple First-Line Therapies. Efforts to create or enhance these features for the benefit of wildlife would likely face numerous obstacles.

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The osteotomy then was performed in a variety of scenarios drink alcohol while taking levaquin in order to simulate the surgical correction. Administration of PRL (10(-7) and 10(-6) M) resulted in dose-dependent increases in corticosterone and progesterone release. Together these findings suggest that smoking induces oxidation injury, promotes altered (iso-)eicosanoid production and impacts on the function and dysfunction of peripheral lymphatics under normal circumstances and in a variety of clinical disorders. Ultrastructural and histochemical abnormalities of skeletal muscle in patients with chronic vitamin E deficiency. Cadmium-induced synthesis of metallothioneins in human T and B cell purified by a fluorescence activated cell sorter. The 2-4 rings PAHs were the dominant components in the gas phase while PAHs in the particle phase were dominated by 4-6 rings. In the other case, a grade 1/6 murmur indicative of regurgitation prior to the procedure increased to a grade 2/6 afterwards. A predictive pharmacokinetic-pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination. Unexpectedly the high risk allele carriers performed better in the verbal working memory task than the other subjects. In the study of radioactive ligand binding assays, arotinolol showed high affinities for both beta 1- and beta 2-adrenoceptors.

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