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Duphaston (Dydrogesterone)

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Duphaston is a synthetic progestogen and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders in women caused due to a lack of hormones. It is also used to reduce the risk of miscarriages or abortions. This medicine is not recommended for use in patients below 18 years of age.

Other names for this medication:
Climaston, Dabroston, Didrogesterona, Didrogesterone, Dirogest, Dufaston, Dydrogesteron, Dydrogesterone, Dydrogesteronum, Femaston, Femoston, Femphascyl, Gestatron, Isopregnenone

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Artane, Lopid, Cycrin, Crestor, Mobic, Plaquenil, Chloromycetin

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Also known as: Dydrogesterone


Generic Duphaston is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Generic Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Generic Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Generic name of Generic Duphaston is Dydrogesterone. Duphaston is also known as Dydrogesterone. Brand name of Generic Duphaston is Duphaston.


The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Generic Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Generic Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Generic Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Generic Duphaston 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Generic Duphaston 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Generic Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. On continuous estrogen therapy: Generic Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. On cyclic estrogen therapy: Generic Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. If you want to achieve most effective results do not stop taking Generic Duphaston suddenly.


If you overdose Generic Duphaston and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Duphaston overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Duphaston if you are allergic to Generic Duphaston components. It is unknown how Generic Duphaston affects pregnant women or nursing mother. Do not take Generic Duphaston if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders. Be careful with Generic Duphaston if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression. Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Do not stop taking Generic Duphaston suddenly.

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The aim of this study was to determine whether MSC are excellent materials for MSCs transplantation in the treatment of osteoporosis. In brain tissue, all vessels larger than 20 microns are left intact after the passage of the jet stream with a pressure of up to 5 bar, and therefore vessels can be isolated selectively from the surrounding tissue. This study aimed to investigate the incidence of CTEPH after APE in Korea and to determine echocardiographic predictors of CTEPH. Current Research and Future Trends in Interventional Cardiology. Pretreatment with chlorpromazine prevents phospholipid degradation and creatine kinase depletion in isoproterenol-induced myocardial damage in rats. Ample evidence for the additional benefit of such interventions over and above that of standard medical care was found. These 12 had fewer burns than the 30 which did not develop disc new vessels. There was strong evidence for the reliability of ultrasound for measuring AHD, with moderate evidence for MRI and CT measures and conflicting evidence for radiographic methods. Health education should include issues regarding congenital malformations delivered by trained experts.

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Prader-Willi syndrome, the first known human genomic imprinting disorder, is one of the most common micro-deletion syndromes. As alterations in noradrenergic transmission in limbic areas underlie withdrawal symptomatology for many drugs of abuse, the present study sought to determine the effect of cocaine withdrawal on beta-adrenergic receptor (beta(1) and beta(2)) expression in the amygdala. Plasma fatty acids contents and dynamics of the left cardiac ventricle contractions were determined in 48 children with simple obesity. Failure to provide adequate concentrations of estradiol before ovulation results in prolonged effects on expression and localization of uterine genes and proteins that participate in regulating uterine functions during early gestation. Because chemokines direct many lymphocyte movements, molecules that regulate signaling by G protein-coupled chemokine receptors are likely to participate in Ag receptor-induced changes in cell migration.

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Pulse interaction by oscillating pulse tails within a wave train leads to bistable wavelength bands, in which two stable and one unstable wave train coexist for the same wavelength. A systematic and iterative approach was used to extract and reduce the data to draw conclusions. Hydrogen-bonding effects on the fluorescence versus electron-transfer-initiated chemiluminescence spectra of the m-oxybenzoate ion derived from a bicyclic dioxetane. For all but one case examined, we find the steady-state fluctuation in different nodes of the pathways to be effectively uncorrelated. Pelvic prevacid dosing pediatric belt effects on pelvic morphometry, muscle activity and body balance in patients with sacroiliac joint dysfunction. Increase in protein level in the AAF/PH regenerating liver model was demonstrated by Western blotting.

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This paper describes traditional and changing health-related beliefs and behaviors of ethnic Lao refugees now resettled in the United States and how these compare with those of other ethnic groups of resettled refugees from Southeast Asia. There are a number of practices with complex ethical issues (eg, female genital cutting, female and male cosmetic genital surgery). Either or both of the highly conserved proline residues in the Cdk1 phosphorylation consensus sequence motifs were mutated to alanine (Cdc27 P304A or P456A). Cyclophilin B (CypB) is a 21-kDa protein with peptidyl-prolyl cis-trans isomerase activity that functions as a transcriptional inducer for Stat5 and as a ligand for CD147. Hence, phaco-ELT can be considered in glaucoma and ocular hypertensive patients whenever cataract surgery is performed, in order to further reduce IOP or to reduce the requirement for IOP-reducing medications. Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practices in the UK. Complicated MH seems to occur frequently in clinical practice when using IFX, especially in patients with higher indexes of activity at entry. Encephalitozoon cuniculi: Grading the Histological Lesions in Brain, Kidney, and Liver during Primoinfection Outbreak in Rabbits. The findings of nocturnal electropolygraphy were also used in the study.

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The effect of intraoperative sounds of saw and hammer on psychological condition in patients with total knee arthroplasty: prospective randomized study. Here, we provide a summary of the functions and regulations of KLHL20 in several physiological processes and stress responses and its disease implications. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. There was an increase in lumbosacral angles in individuals with raised BMI and WHR. While dental findings of both rickets and osteopetrosis have been reported, there is no published report on the oral and dental findings revia medication guide of osteopetrorickets. Two investigators independently selected the studies and extracted the data. Finally, we find that although the fluorescence emission intensity of acetylethylenediamine-(1,5)-naphthol sulfonate-modified histone H3 is sensitive to octamer structure, SWI-SNF action does not alter fluorescence emission intensity. A facile photolithographic platform for the design of cell-guiding polymeric substrates is introduced.

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Beta-adrenoblockers and isoptin were shown to be effective in the control of supraventricular tachysystolic rhythm disorders, membrane-stabilizing agents are indicated in ventricular extrasystole, and ECS combined with trimecaine, in bradyarrhythmias. Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal model. Nevertheless, the clinical repercussions of the abnormal properties of Hb E are mild, and they may be involved with the prevalence of this hemoglobin in Southeast Asia as a balanced polymorphism in which the advantage to heterozygotes is, as yet, unclear. Laparoscopic adhesiolysis in small bowel obstruction is feasible but can be convenient only if performed by skilled surgeons in selected patients. Patients with PAH who receive placebo are more likely to experience clinical deteriorations. A palpable, pulsatile pelvic mass in a patient with a history of hysterectomy should prompt referral for radiographic evaluation of a possible pelvic arteriovenous fistula. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. These assumptions are easily satisfied in a quantitative computed tomography (QCT) setting.

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Over a 30-month period 34 patients with TGA underwent MRI including DW imaging within 4 days of symptom onset. A relationship between tumor dissemination process and the condition of neuro-regulatory mechanisms of target-organ was established. Myeloperoxidase (MPO) was rapidly identified as a therapeutical target because of its involvement in chronic inflammatory syndromes. Older patients with multiple chronic conditions may be at higher risk of receiving poorer overall quality of care compared with those with single or no chronic conditions. Type 2 diabetes mellitus (T2DM) is a metabolic disease that is also accompanied by hippocampal atrophy, and therefore can serve as a model for ascertaining the relationship between CAR and hippocampal volume.

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Syncytiotroblasts were rarely labeled and were considered to be inactive with regard to cell proliferation. Screening and intervention approaches for youth in the urban ED should address the co-occurrence of depressive symptoms with peer and dating violence, alcohol and nonmarijuana illicit drug use. A study was performed focusing on the evaluation of a new magnification system, the Varioscope M5 (Life Optics, Vienna, Austria), in reconstructive procedures with a perforator free flap. Morphological characteristics of spermatogenesis in the offspring of female rats with chronic alcohol intoxication. This phase I study assessed the maximum tolerated doses (MTDs), safety, pharmacokinetics, and efficacy of combined tipifarnib and docetaxel treatment in patients with advanced solid malignancies. A total of 8941 community residents from Soka City in Saitama Prefecture, aged from 40 to 75 years and without a diagnosis of metabolic syndrome, participated in the baseline survey in 2008 and were followed until 2011. In addition, data about CV safety of paracetamol (acetaminophen) are presented. Age susceptibility of molluscan intermediate hosts to protostrongylid nematodes.

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NMR and docking studies have been performed to study the interaction of this mimic with DC-SIGN in solution demonstrating that this pseudomannobioside is a good ligand for this lectin. This paper proposes a multilevel segmentation methodology for efficiently segmenting intracranial aneurysms in CTA images. Because the 55-Kdalton form contains 33- and 22-Kdalton components connected by a disulfide bond, the epitope domain is present on the 33-Kdalton chain. This research suggests that new models of health reform are needed that will effectively bridge the growing gaps between public and private resources, primary and secondary and/or tertiary care, and clinical and public health services. Our study indicates that the fetal brain vascularization and blood flow correlates significantly with the advancement of GA.

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Basing on the results of several experiments and own experience, the author discusses an effect of low-magnesium diet on histological, histochemical, and microscopic lesions to the myocardium, skeletal musculature, liver, and pancreas. Hemosuccus pancreaticus in a patient with iodine allergy: successful diagnosis with magnetic resonance imaging and treatment with transarterial embolization using carbon dioxide as the contrast medium. FCD is usually seen on MRI as cortical thickening, with or without signal change, which may extend into the adjacent white matter. The present author examined 84 patients with chronic mesotympanitis. Our results suggest that the ATM protein is more strongly correlated with PCNS DLBCL lymphomagenesis than with non-CNS DLBCLs, especially in germinal center B-cell-like subtypes demonstrating low Ki-67 labeling indexes and low Bcl-2 expression. Motor function, brain hemorrhage and lesion size were assessed at 3, 7 and 14 days. In comparison to other malignant germ cell tumors, dysgerminomas of the ovary show a high sensitivity to radiotherapy. Data on patient demographics, disease characteristics, treatment strategies, morbidity, and mortality were compared. The double Y-shaped design is recommended when using biodegradable plates in fixation of sagittal split ramus osteotomy. Very young age is not a contraindication to surgery in children with refractory epilepsy, and early surgery may impact development positively.

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