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Imitrex (Sumatriptan)

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Imitrex works on the serotonin (or 5-HT) receptors located on blood vessels in your brain. This causes them to narrow. This helps take away the headache and eases other symptoms such as feeling or being sick and sensitivity to light and sound. Imitrex tablets should work within 30 to 60 minutes.

Other names for this medication:
Migratan, Sumatriptan, Suminat, Sumitrex

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Also known as: Sumatriptan


{name} (sumatriptan) is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

{name} is available as oral tablets, a nasal spray, and as an injection. It used to treat migraine headaches in adults. {name} will only treat a headache. It will not prevent headaches or reduce the number of attacks.

{name} should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.


Do not use this medicine for a headache that is different from your usual migraines. Talk to your doctor about what to do for regular headaches.

To relieve your migraine as soon as possible, use this medicine as soon as the headache pain begins. Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using sumatriptan.

Ask your doctor ahead of time about any other medicine you might take if sumatriptan does not work. After you use the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment.

If you feel much better after a dose of sumatriptan, but your headache comes back or gets worse after a while, wait at least 2 hours before taking another dose. However, use this medicine only as directed by your doctor. Do not use more of it, and do not use it more often, than directed. Using too much sumatriptan may increase the chance of side effects. Do not take more than 200 mg in 24 hours.

Swallow the tablet whole with water or other liquids. Do not crush, break, or chew it.

You may take the tablet with or without food.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For migraine headaches: Adults—25, 50, or 100 milligrams (mg) as a single dose. If you get some relief, or if the migraine comes back after being relieved, another dose may be taken 2 hours after the last dose. Do not take more than 200 mg in any 24-hour period. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions).


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away used syringes or autoinjectors in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Detailed Imitrex Statdose dosage information

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of sumatriptan injection is not recommended in elderly patients with kidney problems, heart or blood vessel disease, or high blood pressure, and should not be used by elderly patients with liver problems.

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Letter from the Guest Editors: Pitfalls in Abdominal Imaging: Part 2. Two single polymorphisms in the MGMT gene, Leu84Phe and Ile143Val, have been reported to affect DNA repair capability and enzymic activity, thereby leading to formation of different cancers. Hepatocellular injury was defined as elevation of serum aminotransferase levels greater than 2 times the reference values. Although pp33 is readily soluble in SDS, SDS-solubilised pp33 is insoluble in non-ionic detergents and is excluded from electrophoretic analysis (IEF, NEPHGE) employing such detergents. These results showed that for some patients this series of blocks provided effective pain relief for 3 months post treatment but by 6 months the pain had returned to pre-treatment levels.

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Inhibitory effects of halothane, isoflurane, sevoflurane, and pentobarbital on the constriction induced by hypocapnia and bicarbonate in isolated canine cerebral arteries. Brain monoamine abnormalities in the two types of Creutzfeldt-Jakob disease. Emotional pictures (IAPS) were used to induce a positive mood in sixteen participants. Primary monolayer cultures of amnion cells were established from women undergoing elective cesarean section before the onset of labor. By using a synthetic octamer oligonucleotide inserted upstream of the beta-globin TATA box we show here that the octamer element by itself is sufficient for directing lymphocyte-specific RNA synthesis when within 70 base pairs of the start site of transcription. However, cerebral perfusion in frontal brain regions as well as basal ganglia is low in FHF as compared to healthy subjects, which may make these regions at risk of hypoperfusion during pronounced hyperventilation. From this observation, we define the term functional macular hole closure, characterized by centripetal movement of the neurosensory retina and improvement in vision, and the broader term anatomic macular hole closure, in which apparent hole closure may result from gliosis in the absence of movement of the neurosensory retina, not associated with visual improvement. We identified 20 patients with this condition, 13 runners and seven non-runner athletes. The effect of investor-owned chain acquisitions on hospital expenses and staffing.

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However, very few double-labeled fibers were found in the proximity of CRH neuronal fibers in the median eminence. Trichomonas vaginalis and Tritrichomonas foetus secrete neuraminidase into the culture medium. We consider that the analysis of our long-term program (based in a single center) of simultaneous pancreas-kidney transplantation would provide valuable information for this therapeutic approach regarding patient and organ survival. A Meta-Analysis to Determine if Lower Extremity Muscle Strengthening Should Be Included in Military Knee Overuse Injury-Prevention Programs. To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (OA). Neither the 20mSTR--estimated VO 2max nor the number of maximal 20mSRT sets were different in the PA 17h and PA 21h sessions. In women with a family history of HD, a third trimester anomaly scan may be warranted. No generally acceptable animal model of chronic epilepsy had been developed, and the non-motor manifestations of epileptic seizures were still largely unexplored experimentally.

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Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation. Gipie participates in the ER stress response in VSMCs and plays an important role in neointima formation after vascular injury. EUS is useful in the preoperative assessment of patients with hypoglycemia and serum hyperinsulinemia. The effect of a single oral dose of triprolidine and pseudoephedrine, singly and combined, on histamine-induced wheal and flare reactions, was assessed in a fully randomised, placebo-controlled, double-blind crossover study. A secondary aim was to describe 4 novel ultrasound biomicroscopy (UBM) measurements for plateau iris syndrome. However, there are inherent uncertainties in the exact effects of ActRatio on the molecular measures of interest. In this context, we investigated whether imipramine alters the biosynthesis of sterols in L. Our results show a better control of relapse of nasal pathology in patients subjected to more radical surgery (group B) vs patients subjected to conservative surgery on middle turbinate (group A). Gnomonia fragariae is a poorly studied ascomycete belonging to Diaporthales.

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Stainless steel grafting of hyperbranched polymer brushes with an antibacterial activity: synthesis, characterization, and properties. We performed psychometric and descriptive analyses to optimise the new instrument. MDCK cells transformed by LMP1 showed invasive growth to form branching tubules into collagen gel without HGF-treatment. Although much has been published about growth of Vibrio cholerae in natural sources of water, little or nothing has been written on its survival in common household water storage containers. The inguinal canal is often seen at the edge of the field of view on plain radiography, computed tomography, or magnetic resonance imaging and may often not be scanned when performing sonography of the scrotum or abdomen. Inhibition of the effect of serotonin on rat ileal transport by cisapride: evidence in favour of the involvement of 5-HT2 receptors. Joint typing of very tightly linked STRs yields stable haplotypes, and can be used for establishing the relationship between distant relatives, such as aunt-niece pairs and cousins. Asaia bacteria dominate mosquito-associated microbiota, as shown by 16S rRNA gene abundance, quantitative PCR, transmission electron microscopy and in situ-hybridization of 16S rRNA genes. Analyses of variance (ANOVA) were computed to determine if significant differences occurred between ABPM and AUS measurements for systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) over the resting and four exercise conditions. In the third step, proton pump inhibitor (PPI)-responsive NUD is discriminated by PPI.

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We report here the development of a novel live cell application of spectral unmixing for the simultaneous monitoring of intracellular events reported by closely-emitting fluorophores responding dynamically to external stimuli. Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. To investigate an alternative method of preprocedural planning for aortic endografting based solely on spiral computed tomography (CT) with 3-dimensional (3D) reconstruction without preoperative arteriography. Evaluation included serum immunoglobulin and complement levels, peripheral blood mononuclear cell subpopulations and lymphocyte stimulation by mitogens. Determining the relative influence of physical and biotic factors on genetic connectivity remains a major challenge for marine ecologists. Chimaeric animals were produced by morula aggregation between histologically distinguishable strains of congenic rats.

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Ectomycorrhizal community structure in a xeric Quercus woodland based on rDNA sequence analysis of sporocarps and pooled roots. The data indicate that the LRR-RLK, PXC1 is involved in secondary cell wall formation in xylem fibers. Thirty-four patients were studied in acute coma on day 1 or 2 after brain injury. Indications were compared with the recommended treatment of major bacterial syndromes as suggested by the major guidelines and textbooks. In vitro 3G9 had a high specific binding capacity with human gastric cancer tissues and cell lines. 10,119 married or cohabiting women ages 15-49 are included in the analysis. This study reviewed the prevalence of MRI abnormalities seen in 45 PBC patients in the past four years, including 33 patients who underwent liver biopsy.

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A 10-year study of Alternaria and Cladosporium in two Polish cities (Szczecin and Cracow) and relationship with the meteorological parameters. Thus, SMC differentiation is dynamically regulated by the interplay between SRF accessory cofactors, the SRF-CArG interaction, and the underlying histone modification program. Abdominal computed tomography (CT) showed an abdominal aortic aneurysm (AAA), a common iliac aortic aneurysm (CIAA) and ACF was suspected. While CN-A alone is inactive in RAS mutant cancer models, combined treatment with CN-A and an anti-EGFR antibody synergistically suppresses tumor growth in vitro and in vivo. A diastereoselective switch in the access to isobenzofuran-derived alpha-selenoesters.

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Morningness-eveningness was evaluated with the Composite Scale of Morningness. Synthesis and antifibrillatory activity of nibentan and its analogues. This retrospective study lacks supportive evidence that any of the clinical syndromes, including the depressive syndromes, is characterized by specific deficiencies of monoamine neurotransmission. This case illustrates the importance of tissue diagnosis in all cases of obstructive jaundice to avoid missing rare but curable diseases. Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?. 5HT(2A) receptor immunolabeling was also observed in GFAP-positive cells of the various brain structures we investigated (layers I/VI of the neocortex, corpus callosum, hippocampal fissure and hilus, and amygdala). Overview of the cytology laboratory: specimen processing through diagnosis.

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Apoptotic cells were detected by double-staining with fluorescent annexin V and propidium iodide. In 24 children with bronchial asthma and 16 children of a control group provocation by three-minute inhalation of cold air was applied under eucapnic condition on a RHES apparatus (E. The binding of some of the antibodies to the antigens was dependent on the type of assay used, suggesting nonrandom binding of the antigen to the solid supports used in ELISA and immunoblotting. A total of 113 sexual offenders (rapists, pedophilic and nonpedophilic child molesters), and 51 nonsexual offenders completed the EMBU (My Memories of Upbringing), the Brief Symptom Inventory, and the Socially Desirable Response Set Measure. Mastication side preference does not significantly impact electrical activity of the anterior temporal and masseter muscles during mastication or in postural position. A novel type of highly effective gemini alkyl glucosides has been rationally designed and synthesized. Neural pathways that mediate the effects of afferent stimuli on paraventricular nucleus multiunit activity in freely moving rats. Volunteers (45) from a university population limited their diet for four days to a commercially prepared liquid diet and provided a 24-hour urine specimen beginning on the morning of the fourth day. If the fetus looses high blood quantities to the maternal blood stream it becomes symptomatic. However, the discrimination of pattern and orientation was also conspicuously impaired, indicating that area V4 is not concerned solely with processing information about wavelength.

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This study was designed to investigate the roles of socioeconomic factors and acculturation in teenage childbearing in this population. Lineage 2 West Nile Virus (WNV) is endemic to southern Africa and Madagascar, and has recently been associated with encephalitis outbreaks in humans and horses in South Africa, central Europe, Italy and Greece. Expression of cell adhesion molecules in laryngeal carcinoma - preliminary analysis. Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. The psychologic management of oncology patients and their relatives. The multi-drug therapy protocol has allowed leprosy patients following this strategy to achieve complete recovery without developing neurotrophic sequelae or deformities.

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Information leaflets were distributed on a large scale to ruminant farms, including hygiene measures to reduce the risk of spread between animals and to humans. Like many global nursing organizations, the KFHI is experiencing nursing shortages and nurses coming to work in this highly specialized area are lacking some of the basic understanding and skills development necessary to work efficiently and effectively in the area. Reflux through the sciatic veins, as the connected superficial varicose veins, disappeared in the entire cohort and only minor complications have emerged. The recent patents have exhibited integration of various functions in the nano-devices requiring sub-nanometer precision and highly stable manipulator with substantial pulling/pushing forces. Our study seems to support the use of combined-modality therapy in patients with neck metastases from carcinoma of occult primary.

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Empirical evidence and theory suggest that traits there can evolve rapidly enough to interact with ecological dynamics, potentially giving rise to accelerating spread. Effects of an invasive ant on land snails in the Ogasawara Islands. On endocrine and exocrine secretory responses was simultaneously investigated during the perfusion of isolated rat pancreases. Integrating training and research with clinical services in a community setting. With a help of theoretical calculations three vibrations were identified as the most active ones in reducing the distance between two heavy atoms, N and O, involved in H-bond formation. Myelin basic protein (MBP) is an antigenic component of circulating immune complexes (CIC) in patients with multiple sclerosis (MS). We posit that these cells are central drivers of costimulation blockade resistant rejection (CoBRR) and propose that CoBRR might relate to an accumulation of CD28(-) T-cells resulting from viral antigen exposure. A community-based parallel controlled trial was conducted among 3 communities. Consistently, T0901317, a synthetic LXR ligand, increased the level of LXRalpha protein in liver.

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Previous surveys have shown that adult workers of the Asian honey bee Apis cerana harbor four major gut microbes (Bifidobacterium, Snodgrassella alvi, Gilliamella apicola, and Lactobacillus). Practical advice on the 10 steps for developing a publishable manuscript is offered in this article. The plateau in the brush region can be assigned to the horizontal to soma medication high vertical rearrangement of whole PFMA chains at the air-water interface, which was followed by XR measurements. Urea fluxes across the urinary bladder of Bufo viridis were studied in vitro after modification of the mounting technique. Characterization of Borrelia burgdorferi strains isolated from Korea by 16S rDNA sequence analysis and PCR-RFLP analysis of rrf (5S)-rrl (23S) intergenic spacer amplicons.

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Our aim was to evaluate if visfatin plasma concentrations may be influenced by a lifestyle intervention. Genome comparisons in oligonucleotide maps show that some oligonucleotides in the genome of the vaccine strain are highly mutable after passage in humans. Experimental investigations conducted mainly by electrochemical impedance spectroscopy suggested that a consistent part of this BZY conductivity is of protonic nature. Water quality improvement policies: lessons learned from the implementation of Proposition O in Los Angeles, California. All articles identified from the data sources that were cytoxan drug insert published in English were evaluated. We evaluated the role of the epithelium following excimer laser in situ keratomileusis (LASIK) performed on highly myopic eyes. Method of determining the summary blood serum toxicity in viral hepatitis. Cross-sectional, national mail survey of resident physicians in their last year of training. The article also provides information on the efficacy, tolerability and an overview of the most important clinical data on GA. Average estimated depth of insertion was 243 cm (range 50 - 380 cm) vs.

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Pinacidil mimics SQTS via increasing potassium outward currents, thereby facilitating inducibility of ventricular fibrillation. The most effective means of prophylaxis was omeprazole administered intravenously during three days followed by oral application during three weeks. This report suggests that detailed neurological evaluation of macrocephalic children with febrile convulsion is important. In both cases, the behavior of lead dissolution could be predicted using available (scientifically verified freeware) models assuming equilibrium between the solid and the aqueous phase. The current approaches to addressing intra- and postoperative complications, provide an understanding of prosthesis infection, and placement of these devices will be reviewed. We first established and characterized two human CDC cell lines designated AP3 and AP8, respectively. A crystallographic snapshot of tyrosine trans-phosphorylation in action. Closer examination of the motions in the most significantly coupled normal mode pairs leads us to propose that, when two similar side-chain squeezing modes are coupled, the rapidly increased van der Waals interactions can lead to a stiffening of the effective potential, which in turn leads to the observed blue-shifts. High-resolution direct infusion-based mass spectrometry in combination with whole 13C metabolome isotope labeling allows unambiguous assignment of chemical sum formulas. Effect of FOY-305 on the activity and secretion of pancreatic enzymes in vitro.

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Prognostic factors in adults with knee pain in general practice. Synthesis of carbocyclic enalapril 40 mg nucleosides bearing a cyclopropane ring. The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. Bird song is a complex behavior that requires the coordination of several motor systems. The surgical management of a penetrating orbitocranial injury with a bakelite foreign body reaching the brain stem. The ezrin, radixin, and moesin (ERM) proteins represent a family of adaptor proteins linking transmembrane proteins to the cytoskeleton. The application of data mining techniques to oral cancer prognosis. Logistic regression analysis was used to determine the factors influencing prognosis.

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