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Indocin (Indomethacin)
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Indocin

Indocin is a non-steroidal anti-inflammatory drug, also known as an NSAID. It treats pain, inflammation, and swelling. Indocin works well for moderate to severe pain, but it should be used carefully when taken long-term since it has some serious side effects.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Also known as: Indomethacin

Description

Indomethacin injection is used to treat patent ductus arteriosus (PDA) in premature infants (babies born too early) who weigh between 500 and 1750 grams. PDA is a heart problem where a blood vessel, the ductus arteriosus, fails to close normally after birth. This blood vessel is only used before birth, and is no longer needed after the baby is born. Indomethacin injection works by causing the PDA to constrict, and this closes the blood vessel. This medicine is used when other medical treatment for PDA fails after 48 hours.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Indocin. Please read with care.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Using too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be used regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. Remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum Remain lying down for about 15 minutes to keep the suppository from coming out before it melts. Make sure to wash your hands with soap and water before and after inserting this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For moderate to severe ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis: Adults and children older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For acute painful shoulder caused by bursitis or tendinitis: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 to 4 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For gout: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, stomach pain, or vomiting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Indocin dosage information

Side effects

The most common side effects associated with Indocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Insulin/IGF-1-like signalling (IIS) and dietary restriction (DR) are the two major modulatory pathways controlling longevity across species. We found evidence for an NE transdifferentiation process and PCDH-PC expression as an early-onset adaptive mechanism following ADT and elucidate AR as a key regulator of PCDH-PC expression. Despite previous successful treatment for amblyopia in that eye, her visual acuity improved from hand motion during the acute episode of endophthalmitis to 20/40 -2. Patients with established familial paraganglioma (PGL) syndrome may have multiple metachronous lesions. Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides.

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The psychiatrist became a member of a general medical team working with a group of internists and actively co-managing medical patients. Hormone profiling revealed the accumulation of abscisic acid (ABA) and ABA metabolites, as well as significant reductions in GA19 and GA53 levels, precursors of the bioactive GA1, in the mutant. The diagnostic problems are obviously increased when it presents as amelanotic metastasis in a lymph node. Prevalence of Neuropathic Pain in Cancer Patients: Pooled Estimates From a Systematic Review of Published Literature and Results From a Survey Conducted in 50 Italian Palliative Care Centers. Light and electron microscopic examination of bone in reflex sympathetic dystrophy syndrome confirms that vascular disorders play an important role in the genesis of bone lesions.

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To study the role of dopamine in the ventromedial hypothalamus (VMN) in the regulation of meal size and meal number during obesity. For patients transitioning between settings of care, particular attention must be paid to any changes to a treatment that has been individualized for a patient. Comparatively little is known, however, about the nature of Fc receptor spatiotemporal organization. Some of the experiments were done with heparin to check if siRNA can be easily disassociated from the complexes, and whether released siRNA maintains its structure after interaction with the dendrimer. Many young women are at increased risk for premature menopause following adjuvant treatment for breast cancer. Lifestyle Behaviour Checklist and the Child-Parent Relationship Scale (CPRS) were used for measurement of parent outcome. To describe an anatomic fibular collateral ligament reconstruction using an autogenous semitendinosus graft and to test the hypothesis that using this reconstruction technique to treat an isolated fibular collateral ligament injury will restore the knee to near normal stability.

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A natural tetranortriterpenoid with immunomodulating properties as a potential anti-HSV agent. Silver staining of the nucleolus organizer regions in the interphase cells of an embryonic pig kidney culture during and after administration actinomycin D. Benign masseter muscle hypertrophy is an uncommon clinical phenomenon of uncertain aetiology which is characterised by a soft swelling near the angle of the mandible. In particular, low frequency/high frequency (LF/HF) is considered an index of cardiac sympatho-vagal balance and is stimulated by glucose ingestion in healthy subjects. To investigate the incidence, clinical and microbiological features of febrile, and risk factors during neutropenia periods in patients with hematological diseases. Resistance to antibiotics: limit theorems for a stochastic SIS model structured by level of resistance. The C-terminus of beta-catenin interacts directly with a region overlapping the CH-3 domain of p300. The present study aims to evaluate the quantity and intensity of the expression of can i take 2 maxolon tablets P53 protein and transforming growth factor alpha (TGF-alpha) in OKC and OOC in order to compare the biologic behavior of these two cysts. Enhancement of myofibrillar proteolysis following infusion of amino acid mixture correlates positively with elevation of core body temperature in rats. Here, we present the synthesis and in vitro characterization of a fluorescent europium-labelled antagonist of RXFP3.

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The serum CK was more in partially ligated than in complete coronary ligated dogs. BCR-ABL1 RT-qPCR for monitoring the molecular response to tyrosine kinase inhibitors in chronic myeloid leukemia. An early drinking study with WSP and WSR mice showed modest evidence consistent with this genetic correlation, but there were several limitations to that experiment. MEDLINE, EMBASE, Cochrane Register of Controlled Trials, and citation review of relevant primary and review articles. To demonstrate this approach, we investigated siderophore production by the marine cyanobacteria Synechococcus sp. Attenuation of the ilvB operon by amino acids reflecting substrates or products of the ilvB gene product. Additionally, we highlight the inherent degeneracies associated with the determination of IDP sub-state populations from NMR chemical shifts alone. Dengue virus infection among children with undifferentiated fever in Karachi. High-intensity focused ultrasound (HIFU) has shown great potential for replacing surgery in many applications.

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