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Nexium (Esomeprazole)
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Nexium

Nexium is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. The medication doesn't have many side effects, but it needs to be taken on an empty stomach in the morning, and it can take up to 4 days to feel its full effect.

Other names for this medication:
Epraz, Esgred, Esodoc, Esofag, Esofine, Esomac, Esomeprazole, Esomper, Esoper, Esotrax, Ignis, Naksium, Neutraflux, Nexpro, Prazonid, Raciper, Ranidom, Sompraz

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Luvox, Precose, Zyrtec, Imodium, Azulfidine, Imuran

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Also known as: Esomeprazole

Description

Esomeprazole injection is used to treat conditions where there is too much acid in the stomach. It is used for the short-term treatment (up to 10 days) of gastroesophageal reflux disease (GERD) with erosive esophagitis in adults and children 1 month of age and older. GERD is a condition where the acid in the stomach washes back up into the esophagus. This medicine is also used to lower the risk of rebleeding in patients with acute gastric or duodenal ulcer after endoscopy.

Esomeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid that is produced by the stomach.

This medicine is to be given only by or under the direct supervision of your doctor.

Dosage

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Take this medicine at least 1 hour before a meal and for the full time of treatment, even if you begin to feel better after a few days.

If you are taking this medicine to treat an ulcer caused by an H. pylori infection, take it together with the antibiotics (eg, amoxicillin, clarithromycin) at the same time of day.

To use the capsule:

Swallow the capsule whole. Do not crush or chew it. If the capsule cannot be swallowed, open it and sprinkle the contents on one tablespoonful of applesauce. Swallow the mixture right away. Do not chew or crush the granules.

To use the capsule with a nasogastric (NG) tube:

Open the capsule and empty the granules into a 60 mL catheter-tipped syringe and mix it with 50 mL of water. Shake the syringe well for 15 seconds. Inject or pour the mixture into the nasogastric tube. Refill the syringe with a small amount of water and shake. Flush the tube to rinse all of the medicine into the stomach.

To use the oral suspension:

Empty the contents of a 2.5 mg or 5 mg packet into a container with 5 mL of water. Empty the contents of a 10 mg, 20 mg, or 40 mg packet into a container with 15 mL of water. Stir and leave it for 2 to 3 minutes to thicken. Stir well and drink within 30 minutes. If any medicine remains after drinking, add more water, stir, and drink immediately.

To use the oral suspension with a nasogastric or gastric tube:

Add 5 mL of water to a catheter-tipped syringe and add the contents of a 2.5 mg or 5 mg packet. Add 15 mL of water to a catheter-tipped syringe and add the contents of a 10 mg, 20 mg, or 40 mg packet. Shake the syringe right away and leave it for 2 to 3 minutes to thicken. Shake the syringe again and inject or pour the mixture into the tube within 30 minutes. Refill the syringe with 15 mL of water and shake. Flush the tube to rinse all of the medicine into the stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or suspension): To prevent NSAID-associated gastric ulcer: Adults—20 or 40 milligrams (mg) once a day for up to 6 months. Your doctor may adjust your dose if as needed. Children—Use and dose must be determined by your doctor. To treat duodenal ulcers with H. pylori infection: Adults—40 milligrams (mg) once a day for 10 days. The dose is usually taken together with amoxicillin and clarithromycin. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. To treat erosive esophagitis: Adults—20 or 40 milligrams (mg) once a day for 4 to 8 weeks. Your doctor may adjust your dose as needed. To prevent erosive esophagitis from coming back, your doctor may want you to take 20 mg once a day for up to 6 months. Children 12 to 17 years of age—20 or 40 milligrams (mg) once a day for 4 to 8 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age and weighing 20 kilograms (kg) or more—10 or 20 mg once a day for 8 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age and weighing less than 20 kg—10 mg once a day for 8 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing more than 7.5 kg to 12 kg—10 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing more than 5 kg to 7.5 kg—5 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing 3 kg to 5 kg—2.5 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Infants younger than 1 month of age—Use and dose must be determined by your doctor. To treat gastroesophageal reflux disease (GERD): Adults—20 milligrams (mg) once a day for 4 weeks. Your doctor may adjust your dose as needed. Children 12 to 17 years of age—20 milligrams (mg) once a day for 4 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age—10 milligrams (mg) once a day for up to 8 weeks. Your doctor may adjust your dose as needed. Children younger than 1 year of age—Use and dose must be determined by your doctor. To treat Zollinger-Ellison syndrome: Adults—40 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.

For oral dosage form (delayed-release 24 hour capsules): To treat heartburn: Adults—20 milligrams (mg) once a day for 14 days. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Nexium and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Nexium overdosage: nausea, feeling confusion, fast heartbeat, convulsions, dry mouth, flushing, blurred vision, short breathing, sweating, tremor, problems with coordination, dyspepsia, migraine, drowsy.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Nexium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

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However, certain limitations of these strategies still exist since insertion of homology arms (HAs) is often based on amplification of DNA sequences with PCR. Within this family, signaling is mediated via a receptor complex consisting of a high-affinity receptor chain and the common gamma-chain (IL-2Rgamma, CD132). Ultrasonography and MRI have limited usefulness for local staging of prostate cancer because of suboptimal sensitivity and specificity for identifying tumor extent and capsular penetration. We analyzed TLR functions and downstream signaling events in both effector T cells. The predictive skill of species distribution models for plankton in a changing climate. Cu feeding rescued the defect in photosystem II protonix medication action electron flux (Phi(PSII)) in the pete1 mutant whereas Phi(PSII) was not changed in the pete2 mutant as Cu was added. It was firmly established that the early heart tube gives rise to the left ventricle only, and that the remainder of the myocardium is recruited from surrounding mesoderm during subsequent development. In patients imaged 6 to 48 hours after stroke onset, DWI frequently provided potentially clinically relevant findings that were not apparent on conventional MRI. One of the controversies surrounding this area relates to which umbrella term should be used to group such symptoms. This study supports the hypothesis of an interaction between SDB and metabolic abnormalities, independent of estimates of body fat distribution, in children and adolescents who are overweight and obese.

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