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Provigil (Modafinil)

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Provigil is a medication used to improve wakefulness in people who have extreme sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. You can take Provigil with or without food. Food doesn't change the overall effectiveness of the medication.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Effexor, Famvir, Priligy, Vasotec, Xalatan, Maxalt, Hytrin, Hydrea

Also known as: Modafinil


How Provigil works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

These actions may result in stimulation of brain activities, which could make you feel less tired.

How long does it take to work?

Provigil begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.


Dosage for adults is 100 mg per day. Take with or without food.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Provigil can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Provigil and other medications

Below is a list of medications that can interact with Provigil. This list does not contain all drugs that may interact with Provigil.

Before taking Provigil, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Drugs that change the effects of Provigil

Several medications can lessen the activity of an enzyme called cytochrome P450 3A4 in your body. Taking these drugs with Provigil can cause your body to get rid of Provigil more slowly. This can cause more Provigil side effects.

Examples of these medications include:

  • antiviral medications such as:
    • cobicistat (Tybost)
    • darunavir (Prezista)
    • ritonavir (Norvir)
    • Viekira Pak, Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir)
  • antifungal medications such as:
    • fluconazole (Diflucan)
    • itraconazole (Sporanox, Onmel)
    • ketoconazole
  • antibiotic medications such as:
    • clarithromycin (Biaxin)
    • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)
  • heart medications such as:
    • amiodarone (Pacerone, Nexterone)
    • diltiazem (Cardizem, Cartia XT, Diltzac, Taztia XT, Tiazac, others)
    • verapamil (Calan, Verelan)
Drugs that may be affected by Provigil

Provigil can increase the activity of an enzyme called cytochrome P450 3A4 in your body. This can cause your body to get rid of certain medications more quickly. As a result, these medications may become less effective.

Examples of these medications include:

  • oral contraceptives (consider using a backup method of birth control while taking Provigil, and for one month after stopping it)
  • cyclosporine (Neoral, Sandimmune)
  • midazolam
  • triazolam (Halcion)
Provigil can reduce the activity of enzymes called cytochrome P450 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.

Examples of these medications include:

  • clomipramine (Anafranil)
  • diazepam (Valium)
  • omeprazole (Prilosec)
  • phenytoin (Dilantin, Phenytek)
  • propranolol (Inderal LA, InnoPran XL)
Many other medications may be affected when taken with Provigil. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions.

Monoamine oxidase inhibitors (MOAIs)

Taking Provigil with monoamine oxidase inhibitors (MAOIs) might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature. Provigil should not be taken within 14 days of using an MAOI.

Examples of MAOIs include:

  • isocarboxazid (Marplan)
  • linezolid (Zyvox)
  • phenelzine (Nardil)
  • selegiline (Eldepryl)
  • tranylcypromine (Parnate)

Taking Provigil with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.

Provigil and herbs and supplements

Provigil may interact with certain supplements or herbal products you may be taking. Examples of these include:

  • acacia rigidula
  • bitter orange
  • green tea
  • guarana
  • hordenine
  • Indian snakeroot
  • octodrine
  • St. John’s wort
  • yohimbe

Taking Provigil with marijuana might change how marijuana affects you. Provigil alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This might increase or decrease the effects and side effects of marijuana.

Provigil and foods

Provigil may interact with certain foods you may eat.

Fruit juices

Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Provigil might change how your body handles the drug. This could increase the amount of Provigil in your body and increase your risk of side effects.

Foods and beverages that contain caffeine

Caffeine in foods and beverages might add to the stimulant effects of Provigil. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others.

Examples of foods and drinks that contain caffeine include:

  • coffee
  • chocolate
  • soda
  • tea (such as black, green, and oolong)

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