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Singulair

Singulair is a prescription medicine used for asthma prevention and for the treatment of allergy symptoms such as sneezing and runny nose. It reduces inflammation in the airways and make breathing easier.

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Also known as: Montelukast

Description

Singulair tablets, produced by Merck Sharp & Dohme, are indicated in the treatment of asthma as add-on therapy in those patients with mild to moderate persistent asthma who are inadequately controlled on inhaled corticosteroids. It helps prevent the wheezing, chest tightness, and shortness of breath caused by asthma and decreases the number of asthma attacks. The medicine is used to prevent exercise-induced bronchoconstriction (narrowing of the air passages in the lungs). It also helps treat seasonal and perennial allergic rhinitis. The active substance contained in the medication is Montelukast, a leukotriene receptor antagonist, that stops leukotrienes, chemical messengers in the immune system, from causing inflammation in the lungs and nose, preventing asthma symptoms and allergies.

Dosage

Usual Adult Dose of Singulair for Allergic Rhinitis:

-10 mg orally once a day Comments: -For asthma, efficacy has been demonstrated when this drug was administered in the EVENING without regard to time of food ingestion. -For allergic rhinitis, efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. Uses: -Prophylaxis and chronic treatment of asthma -Relief of symptoms of seasonal allergic rhinitis and perennial allergic rhinitis

Usual Adult Dose of Singulair for Asthma -- Maintenance:

-10 mg orally once a day Comments: -For asthma, efficacy has been demonstrated when this drug was administered in the EVENING without regard to time of food ingestion. -For allergic rhinitis, efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. Uses: -Prophylaxis and chronic treatment of asthma -Relief of symptoms of seasonal allergic rhinitis and perennial allergic rhinitis

Usual Adult Dose for Bronchospasm Prophylaxis:

-10 mg orally once a day at least 2 hours before exercise Comments: -An additional dose should not be taken within 24 hours of a previous dose. -Patients already taking this drug daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. -A rescue short-acting beta-agonist should be available at all times. -Daily administration for the chronic treatment of asthma has not been established to prevent acute episodes of EIB. Use: Prevention of exercise-induced bronchoconstriction (EIB)

Usual Pediatric Dose of Singulair for Asthma -- Maintenance:

Less than 12 months: Not approved. 12 to 23 months: -One sachet of 4 mg oral granules once a day 2 to 5 years: -4 mg chewable tablet or one sachet oral granules once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Doses should be taken in the evening. -Efficacy has been demonstrated for asthma when this drug was administered in the evening without regard to time of food ingestion. Use: Prophylaxis and chronic treatment of asthma in pediatric patients 12 months of age and older

Usual Pediatric Dose of Singulair for Allergic Rhinitis:

Seasonal Allergic Rhinitis: Less than 2 years: Not approved. 2 to 5 years: -4 mg chewable tablet or one sachet of 4 mg oral granules once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Perennial Allergic Rhinitis: Less than 6 months: Not approved. 6 to 23 months: -One sachet of 4 mg oral granules once a day 2 to 5 years: -4 mg chewable tablet orally once a day 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Efficacy has been demonstrated for asthma when this drug was administered in the MORNING or EVENING without regard to time of food ingestion. -The time of administration may be individualized to suit patient needs. Uses: -Relief of symptoms of seasonal allergic rhinitis in patients 2 years of age and older -Relief of symptoms of perennial allergic rhinitis in patients 6 months of age and older

Usual Pediatric Dose for Bronchospasm Prophylaxis:

Less than 6 years: Not approved. 6 to 14 years: -5 mg chewable tablet orally once a day 15 years or older: -10 mg tablet orally once a day Comments: -Dose should be taken at least 2 hours before exercise. -An additional dose should not be taken within 24 hours of a previous dose. -Patients already taking this drug daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. -A rescue short-acting beta-agonist should be available at all times. -Daily administration for the chronic treatment of asthma has not been established to prevent acute episodes of EIB. Use: Prevention of exercise-induced bronchoconstriction (EIB) in patients 6 years of age and older

Detailed Singulair dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep this medicine in the original bottle. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Singulair are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take the Singulair if you are allergic to Montelukast or any of the other ingredients of this medicine. Do not use the tablets to treat an acute asthma attack, including Status Asthmaticus. Do not use the drug if you suffer from severe kidney failure. Do not combine the medication with drugs which induce the CYP450 enzyme system (phenobarbital and rifampin), as they may decrease the effects of Montelukast. Do not use the medication if you have a phenylketonuria, as Singulair contains phenylalanine. Do not take the medication tablets during pregnancy or while breastfeeding without consulting your doctor. Avoid drinking alcohol while taking Singulair tablets, as it may cause excessive drowsiness. Do not give this medicine to children less than 2 years of age.

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The Rab/Ypt small G proteins are essential for intracellular vesicle trafficking in mammals and yeast. Efficacy of ultrabrief pulse electroconvulsive therapy for depression: a systematic review. Certain antigen-binding surface molecules and factors of T cells possess serological determinants related to immunoglobulin (Ig)-heavy-chain-variable regions (VH). The Task Force was charged with reviewing existing data and developing clinical recommendations for the use of PET scans in the evaluation and management of breast cancer, colon cancer, non-small cell lung cancer, and lymphoma. In patients with hypertension, age and the level of diurnal and nocturnal systolic blood pressures measured by 24-hour AMBP are important independent predictors for the onset of AF. Antioxidant-rich berries consumed in the diet can positively diovan medicine impact learning and memory in the aged animal.

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MVD and VEGF expression was correlated with clinical characteristics and outcome. Experiments were performed for at least 16 h, and we found that cellular attachment and spreading kinetics can be followed in situ by observing the change in dissipation and frequency with time. Two alternative mechanisms for reoxidizing cytosolic NADH are discussed: (i) cytosolic production of ethanol followed by its intramitochondrial oxidation and (ii) a redox shuttle linking cytosolic NADH oxidation to the internal NADH dehydrogenase. For multiple myeloma patients who have, on plain radiograph(s) or imaging studies, lytic destruction of bone or spine compression fracture from osteopenia, intravenous pamidronate 90 mg delivered over at least 2 hours or zoledronic acid 4 mg delivered over at least 15 minutes every 3 to 4 weeks is recommended. Lipid-transfer proteins in membrane trafficking at the Golgi complex. Altered molecular repertoire of immune system by renal dysfunction in the elderly: is prediction and targeted prevention in the horizon?. EMR-B might be considered safe and effective for the diagnosis and treatment of lesions measuring less than 10 mm in diameter. A theoretical model is given for the correlation matrix of a partially correlated source created by placing an azimuthal polarization vortex mode converter in the pupil plane of a critical illumination system. We discuss i) the four metal-binding sites so far described on HSA, their localization and metal preference, ii) the binding of the metal ions mentioned above, i.e. Differential gene expression in ovaries of Qira black sheep and Hetian sheep using RNA-Seq technique.

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