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Soflene (Adapalene)

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Soflene works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Acneril, Acneris, Acniriv, Acnovate, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Temovate, Seroquel, Aldactone, Ilosone, Cordarone, Loxitane, Motilium, Revia, Detrol, Cardizem

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Soflene exactly as directed. Soflene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Soflene. Soflene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Soflene. Continue using Soflene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Soflene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Soflene dosage information

Side effects

The most common side effects associated with Soflene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme. The fortification of bread and salt has resulted in a desirable increase in iodine intake, and the current fortification level of salt (13 ppm) seems reasonable. Twenty-two consecutive cases of the Christiansen total hip arthroplasty revised because of aseptic loosening were analyzed with regard to radiographic changes and operative and histopathologic findings. Spatial changes in ICC network structural properties have not been quantified. Vibrational spectroscopy to support the link between rheology and continuous twin-screw melt granulation on molecular level: A case study. Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans. The combined vaccination was able to induce similar strain-specific hemagglutinin inhibition (HI) antibodies as vaccination of split virus alone. Promoter hypermethylation of CST6 is associated with aberrant AKT1 activation in epithelial cells, as well as the disabled INNP4B regulator resulting from the suppression by CAFs. Pathogen nutrient acquisition and metabolism are critical for successful infection and colonization.

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This age-dependent and diagnosis-specific influence of cannabis may need to be factored into the design of future cognitive studies in SCZ. Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and amplify innate and adaptive immunity. Investigation on the epidemiology of Far-East tick-borne spotted fever in the Northeastern area of China. Enhancement of cell biomass and cell activity of astaxanthin-rich Haematococcus pluvialis. The interface of an atomic qubit with a single spatial light mode, and the ability to independently address the two atomic qubit states, should provide the basic interferometrically robust element of a quantum network. Subacute and chronic hypersensitivity pneumonitis: histopathological patterns and survival. In the whole cohort of 528 subjects, the G allele was observed with a frequency of 0.26. We evaluated the endotoxin activity assay (EAA) for assessment and prediction of the severity of AC.

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Demographic data, clinical characteristics and the exact time of symptom presentation, registration at the emergency department and the first ballooning were retrospectively evaluated. The present study aimed biochemical and histochemical analysis of type IIC fiber in soleus, gastrocnemius and extensor digitorum longus (EDL) at neonatal period, 10 days, 3 weeks, 4 weeks and adult. Further trials are needed to confirm the results of this study and to define the optimal dose and frequency of administration of MLN-02. Metagenomic profile of the viral communities in Rhipicephalus spp. Successful prevention of condensation on the silicone IOL during the fluid-air exchange. The type D lesion showed an agglomeration of Type A-C morphological changes occurring together, in addition to which focal submucosal haemorrhages were seen with severe congestion. Increasing fibre or protein in postnatal diets causes rapid change in satiety hormone secretion and genes involved in glucose and lipid metabolism which appear to influence fat mass and glycaemia in adulthood, high protein being associated with increased susceptibility to obesity. In this paper we use a panel of manufacturing firms in Spain to examine the extent to which they use internal and external sources of information (customers, suppliers, competitors, consultants and universities) to generate product and process innovation. These 688 respondents were asked whether they were willing to become living kidney donors if the government provides a reasonable amount of financial incentive.

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Allergic contact dermatitis (ACD) is a common skin disorder that has a high socio-economic impact with regard to the increasing number of industrial allergens that has potential harmful effect on the skin of manual workers. The VTE risk is increased in patients with natural anticoagulants deficiency, but additional studies are warranted to better assess the risk of VTE recurrence. Risk of Reactivation of Hepatitis B Virus Infection in Psoriasis Patients Treated With Biologics: A Retrospective Analysis of 20 Cases From the BIOBADADERM Database. Determination of levodopa by capillary electrophoresis with chemiluminescence detection. Essential hypertension (EH) is the most common diagnosis in this disease, suggesting that a monocausal etiology has not been identified. Conformational studies of human milk oligosaccharides using (1)H-(13)C one-bond NMR residual dipolar couplings.

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Intravenous administration of physostigmine has been found to produce dose- and time-dependent alterations of the lumbar monosynaptic and polysynaptic reflexes in spinal cats. The distinction of these molecular electronic building blocks is that for first time, (i) the Tour wires are used as the conductive backbone for the rectifying junctions, (ii) donor/acceptor principles are implemented in the molecular wire itself and (iii) the logic gates are realized using molecular rectifying diodes embedded in the molecular conducting wire itself. The deltoid artery supplies the skin over the shoulder by numerous small branches which emerge from the intramuscular septa of the deltoid muscle. Modeling dose-response in amblyopia: toward a child-specific treatment plan. We previously showed that the epithelial cell-type-specific proteins epithelial splicing regulatory proteins 1 (ESRP1) and ESRP2 are important for the regulation of many AS events that are altered during EMT. Here we analyse the long-range structure of the manuscript using methods from information theory. Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia. Incidence and mortality of hepatocellular carcinoma (HCC) has increased markedly over the last three decades in Australia. Although these measurement methods have limitations, BMI and skinfolds are adequate surrogate measures of relative adiposity in children when DXA is not practical. This could promote ownership and correct use of the measure by clinicians, potentially improving practice and the quality of care provided through patient-reported outcome measure data use in clinical decision-making.

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Efficacy of patient-controlled epidural analgesia after initiation with epidural or combined spinal-epidural analgesia. SLN IFS evaluation in DCIS has a low yield and sensitivity, and can be safely omitted to reduce operative duration and cost. The study was performed before and during infusion, and afterward when the patient was on oral drug therapy. Homozygosity for the 5, 10 methylene tetrahydrofolate reductase mutation was shown only in the affected twin after the parents were found to be heterozygous for the mutation. Hydrogen peroxide provoked the activation of MCP-1 and SDF-1 mRNA and their respective receptors, CXCR4 and CXCR2. In this case study, the significance of perfusion abnormalities in catatonia is examined. Furthermore, to determine the eliciting dose (ED) for lupine using double-blind placebo-controlled food challenges (DBPCFC). Thus, 17-DMAG would exert a therapeutic effect on SBMA via preserved proteasome function. Mitogenomes from The 1000 Genome Project reveal new Near Eastern features in present-day Tuscans. A major target of HCMV is the anaphase-promoting complex E3 ubiquitin ligase, which is responsible for the ubiquitination and subsequent degradation of cyclins A and B and other cell cycle proteins at specific phases in the cell cycle.

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Role of arginine residues in the coagulant activity of high molecular weight kininogen. Knowledge or skills in interpersonal communications, social impact of IT on health, and data mining may represent important skills for future informaticians. In addition, genetic studies in animals underscore the role of the system in normal development. Tacrolimus and other immunosuppressive agents may be associated with optic nerve toxicity. WD Repeat and FYVE domain containing 1 (WDFY1)-protein acts downstream of NRP2 for this function. It has, however, been difficult to estimate the relationship between connectivity and function throughout the whole cingulate cortex within the human brain.

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Investigation of orofacial stem cell niches and their innervation through microfluidic devices. Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion. In this test, erythromycin (macrolide) and clindamycin (lincosamide derivative) discs are placed adjacent to each other over the Mueller Hinton agar medium inoculated with the test organism. At 14 and 90 days postimplant, tissue/prosthesis specimens were subjected to histological, immunohistochemical, shrinkage, and biomechanical analyses. Epitopes defined by neutralizing antibodies with strain and type specificities appeared spatially distant but competition between type-specific neutralizing antibodies and some non-neutralizing antibodies against type and group determinants suggested close proximity among epitopes in these regions. Prediction of movement responses to noxious stimuli during anaesthesia is of clinical importance. The pattern of PI-release showed that if objects could be stored and retrieved both by (non-perceptual) semantic and (perceptual) shape information, then shape information was overruled by semantic information. Computed tomographic diagnosis of an ileocolic invagination in an adult. Jie Lu has also been used to form the rational base of the TCM treatment.

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Hepatocellular carcinoma (HCC) was considered based on the image findings and underlying HBV infection. Characterization of an ATPase on the inside of rat-liver nuclear envelopes by affinity labeling. In a cross-sectional study, vertical ground reaction force (GRF) during 2 speeds of walking were compared between 3 age- and sex-matched groups: back pain only (BPO) group, back pain with referred leg pain (LGP) group, and a control group. The mean tumor volume was 0.11 cc, with half of the cancers being less than or equal to 0.01 cc in volume. Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, appear to have clinically significant anticarcinogenic effects in the gastrointestinal tract. In this study, we aimed to examine the clinical effects of rikkunshito on patients who were to undergo PPG. Testing the quality of a carrier: a field experiment on lizard signalers. It seems justified to conclude that simple, schematic drawings emphasizing the important points are better for orientation and recollection than the more correct, but also more detailed type of figures.

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Annexin I, a member of the calcium- and phospholipid-binding annexin superfamily of proteins, is largely present in human neutrophils. On day 21 (term in rat) the staining was fairly homogeneous throughout the connective tissue stroma. Even though AD are rapidly suspected, the GP is often exposed to the difficulty of screening and the complexity of the various biological tests at his disposal. Genetic characteristics of pneumococcal disease in elderly patients before introducing the pneumococcal conjugate vaccine. The performances of young and aged rats were compared on a spatial (spatial delayed nonmatching-to-sample) and a nonspatial (object delayed nonmatching-to-sample) test of working memory. Since the protein p53 is also regarded as nuclear matrix protein facilitating actin cytoskeletal binding, 2D tractions were measured. This paper provides an overview of aetiology and diagnosis of tooth wear, in particular tooth wear due to erosion, so that medical and dental practitioners may recognize tooth wear early, institute preventive measures and manage patients appropriately. We have study the effects of these substances upon the acute inflammation and the immunity system of the experimental animals. The general characteristics of the method and some clinical results are here presented.

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Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. Our results showed that the membrane-permeable alkylating agent (NEM) does not inhibit current reduction determined by thimerosal. The novobiocin biosynthetic gene cluster from Streptomyces spheroides NCIB 11891 was cloned by using homologous deoxynucleoside diphosphate (dNDP)-glucose 4,6-dehydratase gene fragments as probes. Molecular assay of -alpha(3.7) and -alpha(4.2) deletions causing alpha-thalassemia by denaturing high-performance liquid chromatography. Kinetics of appearance of sulfhydryl groups in alpha 2-macroglobulin on reaction of the inhibitor with amines. An instrument combining an electrospray ionization source and a velocity-map imaging spectrometer for studying delayed electron emission of polyanions. The lysogenic state of bacteriophage lambda has been a key model for understanding gene regulation. Myelin-associated glycoprotein (MAG) is a quantitatively minor component in both peripheral and central myelin sheaths that is thought to have a role in cell-cell interactions within the nervous system.

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Compressive viscoelasticity of freshly excised mouse skin is dependent on specimen thickness, strain level and rate. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. The activity profiles for the various substrates assayed show rather complex distribution pattern demonstrating kallikrein-like amidolytic activity in plasma membranes, basolateral membranes, rough endoplasmic reticulum and membranes derived from the Golgi complex. The results of the clinical trials carried out in large patient groups and based on a double-blind methodological design have allowed pharmaceutical registry of this form of treatment, with the therapeutic indications of rhinitis and allergy to grasses. The study of 300 assemblerriveters and metal workers engaged in mechanical assembly shows that workers with elevated content of fat tissue and relatively small amount of osteal and muscular tissue, i.e., representatives of the abdominal somatype, are most resistant to local vibration. There was a high correlation between the ratio for CSF/serum albumin concentration and the CSF total protein concentration. Clinico-morphologic analysis of compensatory and adaptive processes of the kidneys in chronic glomerulonephritis.

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The complete nucleotide sequence of Sri Lankan cassava mosaic virus (SLCMV) DNA-A isolated from cassava in southern India was analyzed, a phylogenetic analysis with other begomoviral nucleotide sequences was performed and an efficient inoculation method of Nicotiana benthamiana with the cloned DNA was developed utilizing a biolistic device. The new model described the quantitative relationship between the WEC of drinking water source and of the river, and it factually expressed the continuity and interplay of these low water areas. OCTA is an effective, non-invasive imaging technique that can offer additional information regarding the morphologies and vascular characteristics of macular lesions in paediatric ophthalmology. Randomized controlled trials comparing the efficacy of ultrafiltration and intravenous diuretics in patients diagnosed with hypervolemic acute heart failure neurontin overdose death were included. In vitro ALP and osteocalcin gene expression analysis and in vivo biocompatibility of N-methylene phosphonic chitosan nanofibers for bone regeneration. While a number of factors related to stage of progression replicated across studies, few variables uniquely predicted a particular stage or transition in smoking behavior. (2007) extend the understanding of the consequences of missing-self recognition in immune evasion and immune cell regulation via NKRP-1 and CD94-NKG2A inhibitory receptors, respectively.

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