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Xabine (Capecitabine)
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Xabine

Xabine is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Neurontin, Altace, Xenical, Nizoral, Actos, Zyprexa, Lamisil, Provigil, Medrol

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xabine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xabine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xabine dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Triamcinolone topical dosage information

Side effects

The most common side effects associated with Xabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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We feel that these results suggest that epicutaneous exposure to allergen may play an important role during both the sensitization and the perpetuation of AD, and provide support for the use of a canine model in the investigation of the pathogenesis of AD. To construct a bait expression vector containing the duck circovirus Cap gene for use in the yeast two-hybrid system, the whole cap codon-optimized gene was inserted into pGBKT7 vector and confirmed by PCR, restriction enzyme digestion, and sequence analysis. The extended leader peptide of Haemophilus parasuis trimeric autotransporters conditions their protein expression in Escherichia coli. Discrepancy between human T-cell lymphotropic virus type I screening test and confirmatory tests in non-endemic areas. A participatory assessment of ecosystem services and human wellbeing in rural Costa Rica using photo-voice. We report here a 12-year-old male child who presented with severe headache, vomiting and meningismus. This cohort study examined mortality among 169,051 male Vietnam-era veterans ages 40 to 59 treated for psychiatric disorders by the U.S. sinica with no obviously repellency, and it can be used to control the adults of P sinaca in field with no significant effect on the growth of wolfberry leaves.

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Bretschneider HTK was used for cardioplegic cardiac arrest in all patients. Development, optimization and in vivo characterization of domperidone-controlled release hot-melt-extruded films for buccal delivery. The aim of the current study was to investigate whether adenoviral-mediated gene transfer of an endothelial nitric oxide synthase (eNOS) cDNA (AdCMVeNOS) into carotid arteries of the SHRSP may improve endothelial function. The interplay between soil-forming processes and geomorphic dynamics significantly contributed to the PTMs spatial distribution detected in the different pedogenetic horizons and soil features. Prognostic implications of folliculo-stellate cells in pituitary adenomas: relationship with tumoral behavior. Moreover, the effect was more prominent on Gram negative bacteria then Gram positive bacteria and fungus. In this study we describe a novel method for DNA extraction from such specimens containing spores and oocysts of Enterocytozoon bieneusi and Cryptosporidium parvum, respectively.

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Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles. Quantitative Interpretation of Multifrequency Multimode EPR Spectra of Metal Containing Proteins, Enzymes, and Biomimetic Complexes. Energy efficient sensor scheduling with a mobile sink node for the target tracking application. A review of the literature revealed that a variety of factors influenced grade inflation and educators were indeed lenient with their grading practices, which hence attenuates the purpose of grading and evaluation. The results indicated that tartrazine extract significantly enhanced active behavioral response to the open field, increased the escape latency in Morris water maze test and decreased the retention latency in step-through tests.

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it is not clear if gait variability is linked to muscle strength or muscle quality (MQ). Of 25 screened studies, seven articles met eligibility criteria and were included. To investigate the anti-tumor effects of melittin against malignant human glioma cells in vitro. The European Commission Public Health Projects Database and CORDIS were searched for eligible projects, which were then analysed by information openly available online. Short-term application of the inhibitors (2 h before and 30 min after the irradiation by the dose of 8 Gy) significantly decreased the colony-forming ability of HeLa cells. In this study, the effect of celiprolol (beta-1-antagonist with beta-2-agonistic activity) on hemodynamic and electrocardiographic parameters of patients with congestive heart failure due to ischemic (iCMP) and non-ischemic (niCMP) origin should be evaluated. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. To date, the preferred approach to this task largely relies on electrode array implants. Interpretation of thoracic imaging is best done using a systematic approach. Authorized by the Ethics Committee, the present cross-sectional study was conducted with a random sample of patients screened for orofacial pain and primary headaches at a tertiary hospital in Northeast of Brazil.

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The following items are indications for ACT: apparent or progressive neurological symptomatology, protracted or relapsing course of PME, formation of the intracranial liquor hypertension, apparent changes in echoencephalography, and congestive disorders in the eyegrounds. The effectiveness of FET PET was determined by the probability of a correct diagnosis. One-to-one reflective conversations with LIC students when they were at the end of their fourth year were the source of the material analysed. The following case emphasizes the importance of including IgG4-related disease (RD) in the differential diagnosis of intraocular inflammation and multiple cranial nerve palsies. About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of cancer cell. Electron ionization LC-MS with supersonic molecular beams--the new concept, benefits and applications. Outcomes (frequency of pneumonia, modified Rankin Scale (mRS) score at discharge, NIHSS score at discharge, and mortality rate) were compared based on shift change experience and length of stay (LOS) dichotomized at 5 hours after arrival. Among these mediators, thromboxane A(2) (TXA(2)) is recognised as important in bronchial responses and the pathogenesis of airway hyperresponsiveness. Generation and characterization of mice harboring a conditional CXCL12 allele.

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Inhibition of autophagy with 3-MA, BafA and siBeclin 1 increased lactate dehydrogenase (LDH) release but, when autophagy was induced by Rapa, Doxo-induced cardiomyocyte death was decreased. Our reconstruction suggests that, perhaps, the ancestral releasing hormone precursors played a role in controlling energy metabolism and water balance, and that releasing hormone functions as present in extant vertebrates were probably secondarily acquired. However, our results should be interpreted with caution, because the blinding methods were not well used. The relationship between cbfalpha1 and the mechanism of the bone remodeling in the process of orthodontic tooth movement. Our findings further contribute to define the biological functions of these two RBPs in physiological and disease state, strongly encouraging the evaluation of the identified transcriptomic changes at protein level in neuronal experimental models. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland.

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Interrelations of hypocapnia, hypoxia, cerebral blood flow and electrical activity of the brain under voluntary hyperventilation in humans. The recommendations focused on (1) aminosalicylates therapy (regarding dose and appropriateness of coadministration with thiopurines), (2) corticosteroid therapy (regarding dose and route of administration), (3) thiopurine treatment (regarding indications and possibility of withdrawal), (4) anti-tumor necrosis factor therapy (regarding appropriateness of combination with thiopurines, intensification, or discontinuation of treatment), and (5) colorectal cancer (regarding risk and time trends). Expression of PAI-1 in EA.hy 926 cells was determined by measuring the level of mRNA, using relative quantitative reverse transcriptase PCR, and protein, using ELISA. To the extent that this can be interpreted as evidence that public reporting positively affects the (reported) quality in nursing homes, policy makers should carefully choose indicators reflecting care-sensitive quality. Preparing adult branch students for their management role as staff nurses: an action research project. Cell Signal 16: 401-413, 2004), are characterized by the presence of at least one NH(2)-terminal pleckstrin homology domain and two or more ankyrin repeats following the GAP domain.

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In this correspondence, we present an unsupervised texture segmentation method that does not require knowledge about the different texture regions, their parameters, or the number of available texture classes. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. The role of the pharmacist in an operant conditioning program for chronic pain patients. Prevailing environmental conditions were air temperatures over 40 degrees C, water temperature of 37 degrees C, and insolation of up to 2400 micromol m2 s(-1) at midday for several hours at the water surface for four months. Dependent on local licensing, penicillin and tilmicosin appear to be the best candidates for future in vivo studies. To estimate effective solar UV radiation in the production of vitamin D (UVD) we used the relationship proposed by McKenzie et al. Double-layered reconstruction of the nasal floor in complete cleft deformity of the primary palate using superfluous lip tissue. SECOND PROGRESS REPORT OF THE COMMITTEE ON STANDARD METHODS OF SHELLFISH EXAMINATION. Endoscopic findings of small-intestinal Epstein-Barr virus-associated T-cell lymphoproliferative disorder.

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In this review paper, an overview is presented on the role of DCs and their mediators in the pathogenesis of COPD. Of the many possible causes of these complications, bacterial translocation and release of harmful cytokines and oxygen free radicals may play an important role in the pathogenesis of the complications tenormin medicine associated with traumatic hemorrhage. Our aim was to construct and externally validate a CHD GRS, in terms of lifetime CHD risk and relative to traditional clinical risk scores. However, how ESCRT-III polymerization generates membrane curvature remains debated. The perspectives of the challenge and opportunity related to this topic are also presented. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain.

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The objective of this study was to extend work in the Simons Simplex Collection by comparing the phenotypic profiles of ASD probands with or without identified de novo loss of function mutations or copy number variants in high-confidence ASD-associated genes or loci. There is less said about action that can be taken to deal with poor housing conditions. The function of coreceptor as a basis for the kinetic dissection of HIV type 1 envelope protein-mediated cell fusion. With regard to the effects of strong winds--the most detrimental disturbance agent in Europe--monitoring and management has focused on structural damage, i.e., tree mortality from uprooting and stem breakage. Consequence analysis in LPG installation using an integrated computer package. In advanced melanoma, two therapeutic avenues have appeared and have immediately become the standard of care, i.e. PRK and LASIK achieved equal refractive outcomes at all postoperative follow-ups, but LASIK patients were omeprazole and celexa drug interaction twice as likely to experience halos.

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Expression of Ft mutants selected from a library of 10(7) variants induces threefold greater cellular iron loading than mammalian heavy chain Ft, over fivefold higher contrast in magnetic resonance imaging, and robust retention on magnetic separation columns. On the estimation errors of KM and V from time-course experiments using the Michaelis-Menten equation. At 14 days PI, only the 50 mg V/kg was significantly higher in both P-deficient and P-supplemented groups. Detection of free prostate specific antigen (fPSA) on a nanoporous gold platform. Despite such potentially adverse effect, there are only few studies analyzing the effects of resistance training on the parameters that could be altered by such diets.

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Twenty-five percent of patients with a non-hip non-vertebral fragility fracture have an undiagnosed vertebral fracture detected by vertebral fracture assessment during bone densitometric assessment. The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. Selective exclusion criteria to prevent that other treatments or comorbidities could invalidate the results were used. Predictability of clinical outcomes following regenerative therapy in intrabony defects. CRP protein and mRNA expression were significantly upregulated in a time- and dose-dependent manner when HFH were incubated with AGE-MCM. The antiviral study of 21 Chinese medicinal herbs was carried out in vitro and in vivo. A PRELIMINARY REPORT ON THE RESULTS OF A RECENTLY PASSED ORDINANCE REQUIRING A PHYSICAL EXAMINATION OF ALL PERSONS CONNECTED WITH FOOD HANDLING IN RESTAURANTS, BAKERIES, GROCERY STORES, ETC. Subdivision of the neotropical Prisopodinae Brunner von Wattenwyl, 1893 microzide drug class based on features of tarsal attachment pads (Insecta, Phasmatodea).

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The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Yet the role of periplasmic nitrate reductase in denitrification has not been clearly defined. These findings suggest that citral has potential to be developed as an alternative or supplemental agent to mitigate the infections caused by C. Nursing intervention data were collected at each visit using the Nursing Interventions Classification (NIC). New way to define disease is needed to reduce overdiagnosis, experts agree. Environmental applications of composites have attracted the interests of researchers due to their excellent adsorption efficiency for pollutants. Ileal pouch motility is independent from motility patterns of the proximal intestine. CT and Uu cervical mometasone furoate nasal spray overdose infection is closely related to female infertility. Correlation of Technetium-99m Macroaggregated Albumin and Yttrium-90 Glass Microsphere Biodistribution in Hepatocellular Carcinoma: A Retrospective Review of Pretreatment Single Photon Emission CT and Posttreatment Positron Emission Tomography/CT. However, recent advances in knowledge in parasite genetics are giving hope of control.

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We thus sought to evaluate the procedural management and in-hospital outcomes of patients treated for acute myocardial infarction before and after a hospital had been publicly identified as a negative outlier. The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation. This study examined the effects of organic farming practices on species richness and abundance of breeding birds in apple orchards in northern Japan. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Cyclic deformation leads to defect healing and strengthening of small-volume metal crystals. Serum from Entamoeba histolytica-infected gerbils selectively suppresses T cell proliferation by inhibiting interleukin-2 production. Less attention has been paid to the impact of the mosquito protonix over the counter cost chemical environment on insecticide-driven selection mechanisms.

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Stochastic simulation of an associated model further supports that the synthetic gene oscillator can be strongly entrained by aperiodic signals, especially telegraph noise. The present paper discusses some of the difficulties in working with people with an intellectual disability and an alcohol problem, and draws on the sparse literature about alcohol problems in people with intellectual disability. SEM and protein analyses of the Muga silk fiber linezolid psych medication produced in the oil field area have exhibited the deteriorating quality of the silk. We amplified the mRNA for cytokines in peripheral blood mononuclear cells (PBMC) and cerebrospinal fluid (CSF) cells from 18 multiple sclerosis (MS) patients and 21 other neurological patients, using the reverse transcription polymerase chain reaction (RT-PCR). In animal models of heart failure, surgical renal denervation has been shown to improve both renal and ventricular function. Prospective ovarian cancer screening trial between December 1986 and June 1993. Intrahospital AKI occurred in 411 of 1,371 patients during the median follow-up period of 69 months. Hepatic resistance to GH is, at least in part, caused by diminished GH receptors as reflected by diminished circulating GHBP levels. Early hematopoiesis and developing lymphoid organs in the zebrafish.

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