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Xelocel (Capecitabine)

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Xelocel helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. It relieves the symptoms of breast cancer.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Furadantin, Parlodel, Medrol, Atarax, Glucotrol, Seroquel, Ventolin, Ditropan

Also known as: Capecitabine


{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Xelocel for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xelocel for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xelocel dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Meclizine dosage information

Side effects

The most common side effects associated with Xelocel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Xelocel if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Xelocel is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Xelocel .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Xelocel and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Xelocel, and for at least 2 weeks after your last dose.

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However, our knowledge concerning circulating levels of the angiogenic factors in NET patients still remains insufficient. The primary outcome of the trial was the proportion of services implementing all seven healthy eating and physical activity policies and practices targeted by the intervention. This method was used for rapid detection of nisin, pediocin, brochocin A and B, and enterocin A and B from culture supernatants and for detection of enterocin B throughout its purification. They exhibited CFTR at their apical membranes, expressed beta1 integrins at their basal membranes, excluded lanthanum nitrate, and uniformly expressed ZO-1 protein. A noticeable remittance of destructive necrotic changes in hepatic parenchymatous elements and reduction in a volume of proliferative inflammatory infiltration with an acceleration in process of its fibrozation in only periportal zones of hepatic lobules found to be for treatment of chronic hepatitis with Neoselen.

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We queried PubMed(R), for citations to the following: MRSA, HIV/AIDS, Staphylococcus aureus, severe acute respiratory syndrome, Lyme disease, avian influenza, West Nile virus, Chikungunya, Ebola virus and Middle Eastern respiratory syndrome. Perioperative management of patients with obstructive sleep apnea: a survey of Canadian anesthesiologists. A noncontact test procedure to obtain the shape of fast concave surfaces is described. A strategy for the synthesis of mesostructured metal oxides with lower oxidation states. Chemical, mechanical and biological properties of contemporary composite surface sealers. The pain is dull (generally bilateral), is not associated to autonomic signs and usually appears from the age of 50 onwards. To determine the effects of long IGF-I deficiency and treatment on HC in patients with Laron syndrome (LS). Once a dilated coronary sinus is confirmed, further ultrasound evaluation should be performed to search for a potential cause. Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer.

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The secretion and expression level of STC2 were both greatly increased in EMT cells and CRC cells compared with the normal epithelial NCM460 cells. Future comparative characterizations in the immune processing of Golgi complex autoantigens using these viral strains may be useful in obtaining specific insights in the specific anti-Golgi complex autoimmune responses. Recent work in budding yeast and mammalian cells has uncovered a system of iron delivery operating in the cytosolic compartment that involves monothiol glutaredoxins, which bind iron in the form of iron-sulfur clusters, and poly(rC)-binding proteins, which bind Fe(II) directly. Further, SIH in post-TAC transgenic GRK5 mice was able to preserve cardiac function. Erythropoietin (EPO) production is stimulated by hypoxia in the kidney. Finally, we investigated the effect of knockdown of eIF4E on the chemosensitivity of ovarian cancer cells to cisplatin in vitro. An intact low-permeability fibrocartilage is important for limiting fluid exudation from articular cartilage in the hip and knee. The Food and Drug Administration (FDA) Table of Pharmacogenomic Biomarkers in Drug Labeling was utilized to identify anticancer agents containing genomic markers in the Indications and Usage section of the drug label. Twelve different sets of confiscated ecstasy samples were analysed applying both near infrared spectroscopy in reflectance mode (1100-2500 nm) and high-performance liquid chromatography (HPLC).

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Between post-test and follow-up, little change took place in the EE scores of either group. The decrease was greatest in GPs with most positive models of self and, contrary to prediction, least positive models of others. Inflammation is one of major mechanisms contributing to the pathogenesis of myocardial ischemia/reperfusion (I/R) injury. Electrolyte disorders following massive insulin overdose in a patient with type 2 diabetes. Postnatal cytogenetic diagnosis in Spain: analysis, evolution and outcome evaluation over a decade. Integrating individual behaviour and landscape genetics: the population structure of timber rattlesnake hibernacula. Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are often used to bind exposed areas of the MHC alpha-helices. Comparative blood flow measurements on the rat kidney for the reproducibility of Kr-85 clearance curves.

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Design of Rehabilitation Training System with Electromyography Feedback for Stroke Patients. Obstetric patterns of FLM testing have declined, principally in near-term pregnancies, and this could adversely affect neonatal outcome. We investigated whether there were specific ages during early childhood when the time outdoors versus incident myopia association was strongest. Comparative Efficiency of Endo, Lithium Chloride Endo, Desoxycholate-Citrate, and Bismuth Sulfite Media for the Isolation of Eberthella Typhosa. In this study we examined the performance of patients with major depressive disorder (MDD) on tasks of memory and executive function in relation to melancholic features and to cortisol levels. We would like to recommend a compulsory battery of microbiological tests and several immunological investigations phagocytic index, phagocytic number, leukocyte number, differential blood test and serum immunoglobulins with a view to applying an adequate antimicrobial and immune modulating treatment.

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Despite common use of proprioceptive retraining interventions in people with chronic, idiopathic neck pain, evidence that proprioceptive dysfunction exists in this population is lacking. Our solution is to use the root symbol SELENO followed by a letter. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children. The aim of this study was to evaluate the prognostic potential of miR-21 and miR-375 in primary esophageal squamous cell carcinomas (ESCC) and esophagogastric adenocarcinomas (EAC). Moreover, thapsigargin also increased the induction of CD36 expression. Further studies to evaluate implementation strategies and cost-effectiveness in different risk populations are needed as well as drug approval in Europe. Thus, we studied how preinfection with IAV alters host susceptibility to different S.

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The results indicate a role of apoptosis in the formation of ischemic lesion. Increasing evidence suggests that delay discounting may change following effective interventions. Glycolysis inhibition by PIO resulted from direct competitive inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). During diapause as well as after JHA application, expression of two ecdysone receptor isoform genes (EcR-A and EcR-B1) in the midgut increased simultaneously with the increase in hemolymph ecdysteroid titer, followed by an increase in trehalase activity. In patients with CAH undergoing vaginal reconstruction, sonography provides adequate information about the anatomy of the vagina and urogenital sinus for surgical decision-making. Environmental factors such as abundant bodies of water and psychosocial factors such as lack of parental supervision contribute to heightened risk of pediatric drowning in rural China, but little is known about the role of individual characteristics such as knowledge and perceived vulnerability in the drowning risk of rural cost of levaquin 500 mg Chinese children. Clusters of measles cases in Jewish orthodox communities in Antwerp, epidemiologically linked to the United Kingdom: a preliminary report. We found strong evidence for conservation of PPIs, with lower than expected levels of change in PPIs for about a quarter of the proteome. Three-dimensional immunofluorescent double labelling using polyclonal antibodies derived from the same species: enterocytic colocalization of chylomicrons with Golgi apparatus.

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Soliton radiation beat analysis of optical pulses generated from two continuous-wave lasers. Profiles of tamoxifen-related side effects by race and smoking status in women with breast cancer. Causes and correlates of calf mortality in captive Asian elephants (Elephas maximus). In the next two studies, treatment was started 1 week postinfection. Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. Behavior of electrolytes in the skeletal muscles in experimental avitaminosis C.

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In 65 of 71 (92 percent) patients the electromyography recording showed the same result during straining using surface electrodes when compared with needle electrodes. Classification of childhood epilepsy syndromes in newly diagnosed epilepsy: interrater agreement and reasons for disagreement. Significant reductions in the Young Mania Rating Scale (YMRS) have been demonstrated in youth with bipolar disorder. Twenty patients with isolated closed femoral fracture, between the ages 18 and 60 years biaxin antibiotic 500mg , were included in the study. The purpose of this study was to analyze the clinical and CT features of pulmonary artery pseudoaneurysms (PAPs).

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We have developed a new model which permits the incorporation of both the phylogenetic relationships among populations and within-species variations. The DS now described is simple to calculate and may be added to other clinical information when making decisions on whether to proceed to sleep study. We studied WROGI structure, and summarized the experience of specialized ophthalmologic care (SOC) management during local armed conflicts (LACs). The compounds were then identified by their exact masses and characteristic fragment ions, in comparison with the fragmentation behaviors of 19 references. Mab B3 was also used to screen a phage-displayed peptide library and identified a peptide mimicking the Lewis(y) epitope. This circumspect approach reflected dominant business interests and despite relatively robust trade union campaigning and eventual reform, the outcome was an accumulative legacy of respiratory disease and disability that blighted coalfield communities. An entire functional brain system (a basal ganglia-orbitofrontal circuit) enters into a state of enhanced responsiveness following exposure to protracted threat.

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Research has shown that menstrual cycle phase may affect pain sensitivity. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. This article, however, reviews the incidence of respiratory disease both by destination and by travel-related risk groups and factors. Polymerized resin-based materials are successfully used in restorative dentistry. This review provides an update on the autonomic effects of CRF and the neuronal projections thought to mediate these cardiovascular responses. In fact, these adhesive structures do not only physically anchor cells, but they also induce vital intracellular signaling at cell-matrix adhesion sites.

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Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, what is aygestin 5 mg growth and survival of human hepatocellular carcinoma. Randomized controlled trials are needed to test videothoracoscopy versus thoracotomy for lung cancer lobectomy. The feasibility of the technique is demonstrated on a tabletop-scale power-recycled Michelson interferometer with Fabry-Perot arm cavities, and the experimentally measured values of the length-sensing signals are in good agreement with theoretical calculations. For this purpose, a cross sectional study was designed using multiple methods. The purpose of this study was to explore the link between NO and the survival pathway triggered by insulin-like growth factor-1 (IGF-1) and insulin in insulin producing RINm5F cells and in pancreatic islets. Calcium requirements for binding to phosphatidylserine are around 6-fold lower than those required by the A13b isoform. Electrophysiologist-implanted transvenous cardioverter defibrillators using local versus general anesthesia. We demonstrated that AdVING4/p53-mediated p53 and ING4 co-expression induced synergistic growth inhibition and apoptosis as well as enhanced effects on upregulation of acetylated p53, P21, Bax, PUMA, Noxa, cleaved caspase-9, cleaved caspase-3 and cleaved PARP, and downregulation of Bcl-2, CD31 and microvessel density (MVD) in MDA-MB-231 breast cancer in vitro and/or in vivo subcutaneous (s.c.) xenografted tumors.

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Given that most smoking students desire to quit smoking--and that they are enrolled in trade or technical schools for an extended period of time--additional research should examine how successful interventions can be delivered at the trade or technical school itself. Several points to consider have been revealed regarding the management of anesthesia in patients with PC. Our time-course analysis of LMB treatment reveals that the NPC-associated RanGAP1 is much more slowly redistributed to the nucleoplasm than the cytoplasmic RanGAP1. DVT, however, is not the only consequence of patient immobility and venous stasis. Six identified studies, with a total of 153 NEAD participants, examined the impact of receiving a diagnosis on seizure frequency vasotec medication . Toward this end we show here that both Syntaxin 1A and Syntaxin 4 associated with F-actin in MIN6 cells and that each interaction was rapidly and transiently diminished by stimulation of cells with d-glucose. Parathyroid glands: combination of (99m)Tc MIBI scintigraphy and US for demonstration of parathyroid glands and nodules. MicroPET Outperforms Beta-Microprobes in Determining Neuroreceptor Availability under Pharmacological Restriction for Cold Mass Occupancy. The most affected joint is knee but should also be seen in other joints.

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