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Xeloda (Capecitabine)
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Xeloda

Xeloda is in a class of medications called antimetabolites. It works by stopping or slowing the growth of cancer cells. Xeloda is used in combination with other medications to treat breast cancer that has come back after treatment with other medications.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Diflucan, Suprax, Antivert, Aceon, Viagra, Differin, Levothroid, Theolair, Nuvigil, Daklinza

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Xeloda for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Xeloda for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Xeloda dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Xeloda dosage information

Side effects

The most common side effects associated with Xeloda are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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An advantage of the approach presented here is that competing reactions can be incorporated within the model. Changes in tau conformation result in both loss of normal function and gain of fibrillogenicity that leads to aggregation. This paper examines the consequences of using prepayment metering, a payment method typically used by low-income households, on households with children. Nurses must be educated to recognize health-promoting opportunities in the acute setting, as well as how to plan for and conduct health promotion so that it becomes integral to practice. The reaction kinetics of four sheep haemoglobins with identical alpha-chains. This concerns the requirements of animal welfare, meat quality and working conditions in the lairage, stunning and debleeding area.

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In this paper, we will demonstrate that optical spectroscopic techniques such as polarized Fourier transform infrared spectroscopy (FTIR), sum frequency generation (SFG) vibrational spectroscopy, and higher order nonlinear vibrational spectroscopies can be used to deduce different and complementary structural information of molecules at interfaces (e.g., orientation information of certain functional groups and secondary structures of interfacial proteins). Sex differences in the management of acute coronary syndromes in Italy: data from the MANTRA registry. Proceedings from a one-day research workshop on human growth and development. Thus, subgroup Ia species lack an unregulated isozyme of chorismate mutase and arogenate dehydratase, enzymes which are thought to divert chorismate to L-phenylalanine under conditions of high carbon input into aromatic biosynthesis. To our knowledge, this series is the first to identify a familial association in SCAD suggesting a genetic predisposition. A tomato Solanum pennellii introgression population was assessed for fruit yield, biomass phenotypic diversity, and for saccharification potential. The cytoplasmic and nuclear fractions of maspin seem to be closely interwoven. Research in the clinical setting: perspectives from a non-research institution.

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These, in turn, set up a cascade of events coordinated by the central nervous system and at the level of individual tissues such as the liver, gut, and skeletal muscle. The role of taxis for incarcerated hernias in a growing geriatric population must be reexamined. Instillation treatment is first-line therapy for diffuse in situ carcinoma. Using the new procedure we obtained protected PNA monomer backbones with various amino acid side chains. In the second series blood was taken from eight patients with cancer of the gut and from six cholecystectomized patients. In addition, two foreign serum infusions (human plasma and horse serum on the 30th and 60th day, respectively, 350 mg/kg foreign protein/infusion/animal) did not produce a significant effect on spontaneous arteriosclerosis and cholesterol-induced atherosclerosis (4 months atherogenic diet) in the arterial system of swine. A connecting hinge represses the activity of endothelial nitric oxide synthase. Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena.

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The primary aim of the current study was to investigate to what extent an exercise intervention is effective in reducing three indicators of study-related fatigue (emotional exhaustion, overall fatigue, and need for recovery). One of the difficulties in automatically computerized mammogram analysis is the presence of pectoral muscles in mediolateral oblique mammograms because the pectoral muscle does not belong to the scope of the breast. For example, in high-risk patients, it is important to use glucocorticoids in a minimal way, i.e. It has been established that the reduction of arterial pressure as a result of hypotensive therapy (administration of central action drugs, vasodilators of direct action, calcium antagonists, blockers of the angiotensin-transforming enzyme) was followed by a decrease in the blood of the concentration of fatty acids, glycerin, triglycerides, low density lipoproteins, total cholesterol, free cholesterol, phospholipids, characteristics of lipid peroxidation and by the rise of cholesterol concentration in high density lipoproteins. In addition, the resident completed the Maslach Burnout Inventory (MBI) and the Beck Depression Inventory (BDI) prior to starting the shift. Placing multiple genome comparisons in a phylogenetic context improves the sensitivity of evolutionary inferences. TtpsiPCS which resembles a true PCS at the N-terminal region, while it is most divergent in its Cys-poor C-terminal region, was found to be up-regulated under cadmium stress conditions. During placement of the Fletcher suit one of the ureters is catheterized by a special stent which appears on the X-rays control used for dosimetry. Recent studies have suggested that abnormalities of dopamine and trace amines (tyramine, octopamine, and synephrine), products of tyrosine metabolism, may constitute the metabolic events that predispose to the occurrence of cluster headache (CH) and migraine attacks.

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Floral characters like floret number (12.85 and 12.45/spike), floret size (9.76x8.93 and 10.28x9.77 cm) and weight of stick (36.73 and 45.12 g) also significantly influenced by said treatment (B2.0 Zn4.5 kg ha(-1)) which was markedly differed over rest of treatments combination. Thus, the offered RR-OsO4 staining technique may facilitate the study of the NETs-bacterial interactions. We therefore investigated to elucidate the relationships among labial closure force, ADL and cognitive function in frail elderly persons. The agent 5-azacytidine, which directly affects nucleic acid metabolism, is a potent teratogen in NMRI mice. L-5-Hydroxytryptophan (5HTP) (with or without carbidopa pretreatment), L-tryptophan (plus pargyline pretreatment), or tryptamine (plus pargyline pretreatment) all induced dose-dependent myoclonus in guinea pigs. Accumulated neutrophils and macrophages not only reduce the risk of infection but also secrete cytokines and growth factors to promote tissue repair. To determine the effectiveness of targeted exercise training and vitamin D supplementation in reducing falls and injurious falls among older women. Calculated BMI and dietary intake were standardized for age, sex, and race/ethnicity and compared to age-matched US population from the National Health and Nutrition Examination Survey (NHANES). The response variance was found to increase with increasing response strength. Growth of the strain decreased in the presence of oxidants, which induced glrA expression 1.5-6-fold.

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The apoptotic effects and mechanisms of paclitaxel on different permanent HPV-negative HNSCC cell lines (UT-SCC-24A, UT-SCC-24B, UT-SCC-60A and UT-SCC-60B) were determined by flow cytometry assays, polymerase chain reaction analysis, immunofluorescence-based assays and sequencing studies. Molecular cloning and sequence analysis of the rinderpest virus mRNA encoding the hemagglutinin protein. Our data suggest that different CTC populations are identifiable in peripheral blood and that these individual cell type profiles might be used to predict outcome to platinum based systemic therapies in lung cancer patients. Application of time-resolved fluorescence for direct and continuous probing of release from polymeric delivery vehicles. The number of AD8 items endorsed by the participant was compared with informant answers and an independently derived Clinical Dementia Rating.

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Typically, we observe an unintended hyperopic shift after phototherapeutic keratectomy (PTK). The analysis system includes methods to compensate for variations due to exposure and development in serial radiographs. Nano-scale dynamic recognition imaging on vascular endothelial cells. The process of resident assessment is complex and should comprise both quantitative and qualitative data. Fetal and early-postnatal developmental patterns of obese-genotype piglets exposed to prenatal programming by maternal over- and undernutrition. The former can be counted by the rosette techniques or by monoclonal antibodies, while for the latter their function is determined mainly. imuran drug class We study the emergence of discontinuous shear thickening (DST) in cornstarch by combining macroscopic rheometry with local magnetic resonance imaging measurements.

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The innate immune system can recognize non-self through pattern recognition receptors and provides a first line of antimicrobial host defense. Discerning picroside-I biosynthesis via molecular dissection of in vitro shoot regeneration in Picrorhiza kurroa. N-type calcium channels are localized to synaptic nerve terminals in laminae 1 and 2 of the dorsal horn where their opening results in the release of neurotransmitters such as glutamate and substance P. Sustained high quality of life in a 5-year long term follow-up after successful ablation for supra-ventricular tachycardia. His computed tomographic (CT) scan on admission demonstrated a perimesencephalic pattern of subarachnoid hemorrhage. Two male patients with ASD from independent Japanese families possessed inherited missense mutations at conserved sites in GPR85: one had T1033C (M152T) and the other had G1239T (V221L). The effect of Pycnogenol on postprandial glycaemic levels and MNCV was not dose-dependent. Species were grouped into distributional categories according to their worldwide occurrences. To aid discovery of novel antidotes for GF toxicity, a three-dimensional in silico pharmacophore model for reactivation efficacy against GF intoxication is presented.

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Intravascular stenting for stenosis of aortocoronary venous bypass grafts. The maxima of pointing and tracking errors due to the localized distortion with different radii are given. Laboratory strains of coliforms Escherichia coli and Klebsiella mobilis were used to artificially contaminate water samples in two different cultivation and detection systems, without and with bubble flow. Prednisolone co-administered with losartan confers renoprotection in patients with IgA nephropathy. The high risk for adenocarcinoma with low-intensity exposure to wood dust lends support for a reduction in the occupational threshold value. In order to demonstrate the technique, we report on a study in which the variability in timing and signal magnitude of data collected during the performance of two functional tasks is compared between a group of subjects with stroke and a group of individually matched control subjects. Due to its major role in metabolism and host defense mechanisms, it is becoming increasingly evident that the liver is an important organ in the development of multiple organ dysfunction during sepsis. A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis.

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Chiropractors in private practice from 3 Danish counties referred patients with a positive premanipulative test for an examination of vertebral artery blood flow. RESULTS: Patients with a disease-free interval following diagnosis of less than 24 months were more frequently premenopausal and hormone receptor-negative than those with a disease-free interval of 24 months or greater. We used these data to estimate the basic reproductive number for HPAI virus spread. The lesions which were classified into a hazy density, micronodular densities, confluence of various sized ring like shadows and subpleural bullous changes were frequently recognized together mostly in the type of antibiotic flagyl periphery of the lung. Experiment Research on Hot-Rolling Processing of Nonsmooth Pit Surface. Role of Smac in apoptosis of lung cancer cells A549 induced by Taxol. One patient, without other risk factors, developed unilateral ectasia after LASIK following primary hyperopic ablation in an eye suspicious for keratoconus. In human cells RLIP76 accounts for more than two third of the transport activity for GS-E and drugs as opposed to the ABC-transporters including MRP1, which account for less than one third of this activity. A retrospective review was performed in children with albinism who underwent sweep VEP testing from 1992 to 2003.

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These results reveal that syndecan-4 is a primary cell-surface target for R8 peptide that allows intracellular delivery of bioactive cargo molecules via clathrin-mediated endocytosis. These two precursors as well as a third, unidentified polypeptide of Mr 38 000, probably unrelated to the beta subunit of NGF, bound also to microtubules. Effect of aztreonam zyrtec allergy syrup side effects on immunohistochemical localizations of cytochrome P-450 (M-1) in male rats. Delivering an oral presentation at a conference can be a demanding yet exhilarating experience. Based on the results of this study several significant software and hardware improvements have already been implemented.

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Procyanidins caused a time-dependent reduction in the HSL mRNA levels. This awareness will lead to the informed use of existing machine learning methods, thus improving the quality of laboratory diagnosis via informatics analyses. For both models, the variability of efferent spike trains measured by coefficient of variation (CV) of the interspike interval is a nondecreasing function of input correlation. The biological role of fibroblast growth factor receptor 3 (FGFR3) in tumor angiogenesis of hepatocellular carcinoma (HCC) has not been discussed before. A population-based epidemiological survey of migraine without aura and migraine with aura completed by mailed questionnaire in Hungary. With increasing expression of adherens junction components of E-cadherin and beta-catenin, E-cadherin and p-Akt expression increased in 7 days post-confluent Caco-2 cells, and in human intestinal tissue, expression of E-cadherin and p-Akt also increased in the upper portion of villi, compared to the crypt.

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Recurrences after retrorectus mesh repairs are significantly higher with lightweight compared with mid-weight meshes. The identity of the thrombin cleavage site responsible for loss of TAFIa activity was suggested to be Arg(330), but site-directed mutagenesis of this residue did not prevent inactivation of TAFIa by thrombin. From this analysis, the phase transition was found to be most closely described by the 2D Ising model, showing it is a critical transition. For this study, information was collected and analyzed from 1580 female participants recruited from the kink community, using a non-clinical and non-criminal sample. Two unknown species from Chatuchak market were analyzed to be N. Axonal transport of noradrenaline, protein and glycoprotein in cat hypogastric nerves in vitro under conditions of high extracellular glucose.

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Incidence Rate and Results of the Surgical Treatment of Pectoralis Major Tendon Ruptures in Active-Duty Military Personnel. CT colonography is more reliable and accurate than optical colonoscopy for polyp measurement. The result also highlights the importance of direct cell-cell contact between epithelial cells and the surrounding fibroblasts that confer this epigenetic perturbation. Hence we investigated the promoter methylation status and expression level of HOXA11 gene which may involve albenza 2 tablets price in GC development. Simulation of the relative damaging effects of Auger cascades with gel scintillators.

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Many screening hits show relatively poor quality regarding later efficacy and safety. In this age of self-determination, more tribal communities want to partner with others in studies affecting their communities. Improved ethanol production in the presence of cadmium ions by a Saccharomyces cerevisiae transformed with a novel cadmium-resistance gene DvCRP1. An annotated checklist of the Recent non-marine ostracods (Ostracoda: Crustacea) from Italy. The number of invasive candidiasis cases has risen especially with an increase in the number of immunosuppressed and immunocom promised patients. The aim of this study was to moduretic drug document the factors that influence exclusive breastfeeding initiation in Zhejiang, PR China. To compare MRI and clinical staging of invasive bladder cancer prospectively and identify additional prognostic features on MRI before radiotherapy.

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Complications and survival after the surgery were analyzed retrospectively. Closure of the aortopulmonary window alone could have caused acute myocardial ischemia. We reviewed the literature to determine if urine nephrin measurements could become useful as a biomarker to detect early podocyte injury. The production of FNO-alpha and IFN-gamma was analyzed in the culture of peripheral mononuclear cells using antigen M. The purpose of the present study was to determine the results of tourniquet use with slack in the strap versus no slack before windlass turning, in order to develop best practices. Treatment-resistant depression: response to low-dose transdermal but not oral selegiline. Biochars derived from various source materials show different properties of surface area, porosity and the amount of functional groups which are important concerning on the effect of biochar. Spontaneous coronary artery dissection: favorable outcome illustrated by angiographic data. On the basis of our data and on previous findings showing a role for let-418 during development, we propose that LET-418/Mi2 could be part of a system that drives development and reproduction with concomitant life-reducing effects later in life. However, the mechanism(s) of lysoPC-induced inhibition of EC migration nimodipine tablet dose and proliferation has not been clarified.

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