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Zofran

Zofran blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Other names for this medication:
Acidom, Domar, Donrid, Doran, Emeset, Emitus, Emtop, Lupisetron, Naucid, Odanse, Omcet, Ondansetron, Ondar, Ondeo, Ondet, Ondon, Onsett, Ontron, Onzil, Osetron, Pantorex, Periset, Rancet, Ranidom, Ranivir, Ranon, Renol, Renty, Sanron, Supracetron, Tiron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Vorast, Voset, Xondmet, Zonda, Zondan, Zonde

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Also known as: Ondansetron

Description

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran ODT dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age. Safety and efficacy have not been established.

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Pressures to decrease both turnaround time and operating costs simultaneously have placed conflicting demands on traditional forms of medical transcription. Subjective pain response was assessed using the visual analogue scales, and morbidity was evaluated by Common Terminology Criteria for Adverse Events v3.0. When cultivated in mung bean medium, PDG production was significantly improved and pinoresinol monoglucoside (PMG) and pinoresinol (Pin) were also found in the culture medium. An ELISA that detects anti-Toxoplasma IgG, an ELISA to detect circulating antigens, and fecal examinations were performed on samples from each cat for 1 year after inoculation. Here, we present the crystal structure of BcZBP at 1.8 A resolution. Performing half-dose 80-kVp liver CT with SAFIRE technique may increase image quality and afford comparable lesion detectability of hypervascular HCC at a reduced radiation dose compared with full-dose CT with FBP. The observed changes in Group B have caused a more frequent hypotension, use ofvasopressors and infusion. Ultrasonic excitation of a bubble inside a deformable tube: implications for ultrasonically induced hemorrhage.

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Ethics committees to control training procedures of gifted children and to propose higher age limits for participants, especially in international sports events, seem to be needed. Decompression alone and decompression with fusion have been widely used for years in the surgical treatment of lumbar spinal stenosis. Current evidence indicates that angiotensin II activates neurons in the rostral ventrolateral medulla via the AT(1A) receptor. The findings support the hypothesis that tectofugal signals involved in orienting turns descend uninterrupted to the spinal cord on something other than tectospinal axons, and suggest that the critical projections derive from the large cell column of the ventral tegmentum. Mosaicplasty technique in the treatment of osteochondral lesions of the knee. Induction chemoradiotherapy for superior sulcus non-small-cell lung cancer: an answer for few. Assessment of a mechano-regulation theory of skeletal tissue differentiation in an in vivo model of mechanically induced cartilage formation.

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We evaluated whether ox-LDL-induced inflammation depended in part on the activation of TLR4-dependent signaling pathways in a cultured human mast cell line (HMC-1). Dynamic gadopentetate-enhanced MRI was acquired in the rat using a semikeyhole acquisition scheme. are the usual pathogens involved in nosocomial bacterial endocarditis. Induction of ribozyme activity by anti-ribozyme oligonucleotides. Rearrangement of the keratin cytoskeleton after combined treatment with microtubule and microfilament inhibitors. Grafts in the size of at least 3 to 8 cm can be harvested under preservation of the perichondrium. These results are consistent with the idea that MUC1 is involved in trophoblast adhesion to uterine endothelial cells and in trophoblast transendothelial migration.

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Donor retention as a function of donor reactions to whole-blood and automated double red cell collections. Microcirculation disorders as the cause of capsular contraction after augmentative mammoplasty. Ciprofloxacin showed significantly greater in vitro antibacterial activity than enrofloxacin against M. Spectral measurements of the emitted light indicate that it has a colour similar to that of daylight, and images obtained under illumination with this light source indicate that it provides more uniform illumination and sharper shadows than standard endoscopic light sources. Sodium and potassium content of some fresh, frozen and canned vegetables. The benign nature of the lesion was based on histologic examination or clinical and radiologic follow-up (or both). In the past decade, studies using selective DC depletions have demonstrated critical roles of DC in lupus progression. Refractive errors were measured to correlate with anterior chamber depth.

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Effects of aluminum exposure on glutamate metabolism: a possible explanation for its toxicity. The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats. To investigate the contribution of DNA methylation to the establishment of the myogenic program, we analyzed ESCs, skeletal muscle stem cells in proliferating (myoblasts) and differentiating conditions (myotubes), and mature myofibers. To determine the accuracy of this approach in assessing regional thallium deficit size, acute myocardial infarction was produced in six dogs by 24 hour occlusion of the proximal left anterior descending coronary artery. NDSHS data provide reasonably accurate estimates of trends in Australian population alcohol consumption. The same method can be applied to any ensemble of molecules (not necessarily proteins) since our basic technique is sequence order independent. Related articles were also assessed depending on the content of articles found in the original literature search. Neck pain is a common musculoskeletal complaint and a relationship with reduced work-related functional capacity is assumed. New tools for the analysis and production of CYP metabolites, including microscale analytical technologies and combinatorial biosynthesis, are providing medicinal chemists with the opportunity to use CYPs as a novel platform for lead discovery and development. The Fluorescent Antibody Virus Neutralisation test (FAVNt) was used in parallel with the mRFFIT, and the results were compared to the mouse challenge test.

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Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). In this study, we retrospectively analyse the results of the introduction of MF for maintenance and induction therapy in rAAV in our institution from 2001 to 2013. The purpose of this study was to attempt to understand why some injectable fillers produce frequent ill effects and some do not, by reviewing the available agents and analyzing them through the knowledge of biomaterial studies, which show clearly what type of reactions can be expected according to the chemical used. The lesions showed more extensive hyalinization and vascular ectasia reminiscent of cavernous hemangioma. Agents are located in a two-dimensional lattice and can move some discrete space units at each discrete time unit within their neighborhood. Reversible grade 3 nonhematologic toxicity occurred in six patients at level 4, establishing the recommended cumulative dose as 36 mCi/kg. Identification of device malfunction in patients supported with the HeartMate XVE left ventricular assist system. These results collectively suggest that manganese induces COX-2 by transcriptional up-regulation in human airway cells and the induction appears to be cooperatively mediated via multiple signaling pathways and GSH depletion. Estimating the importance of epileptiform abnormalities discovered on cassette electroencephalographic monitoring.

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A community-based sample of 616 high school learners completed self-report scales assessing exposure to six different forms of violence and the severity of depression, aggression and conduct disorder symptoms. Plasma folate levels among pregnant Chinese women increased dramatically after the nation-wide folic acid supplementation program in both rural and urban areas, and in populations of high and low NTD prevalence. During a prospective randomized trial, 50 geriatric patients underwent surgery for a fractured femoral neck. The strategy for the treatment of vascular malformations differs substantially from the one for haemangiomas. Outcome of patients activating an unrelated donor search for severe acquired aplastic anemia.

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In an immunoperoxidase study, pregnancy-associated placental protein A (PAPP-A) was localized to the cytoplasm of decidual stromal cells, the villous syncytiotrophoblast and on the surface of placental trophoblast. Recognition of variant-specific antigens by cytolytic T lymphocytes. Moreover, we think that it is important to elucidate whether there is a heterozygous or a compound heterozygous mutation of the SRD5B1 gene in our two patients. The translocation of tRNA coupled with mRNA in the ribosome is one of important steps during protein synthesis. Serum testosterone levels and testicular weights were significantly decreased by EtOH whereas serum estradiol levels were higher, suggesting enhanced peripheral conversion by EtOH. 2-APB induces instability in rat left atrial mechanical activity. This research further proposes an approach for pedestrian tracking. Rather, current strategies to alleviate poor outcomes focus on clinical risk identification, early detection of injury, modifying clinician behavior to avoid harm, early appropriate antimicrobial therapy, and surveillance among survivors for the longer-term sequelae of kidney damage. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting were performed to analyze the expression of LSD1 and interleukin-6 (IL-6) in THP-1 monocytes and THP-1-derived macrophages.

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Within 2-3 days, 370 MBq 99mTc-MIBI were injected and SPECT acquisition commenced 1 h later. Redox property of ribonucleotide reductase small subunit M2 and p53R2. It is shown that the use of bagging can improve the reliability and stability of both VS and model prediction. We investigate the structural and thermodynamic properties of a new class of patchy colloids, referred to as inverse patchy colloids (IPCs) in their fluid phase via both theoretical methods and simulations. Oestrogen receptors beta genotype in infertile Egyptian men with nonobstructive lopressor 75 mg azoospermia. Auditory Temporal Processing Deficits in Chronic Stroke: A Comparison of Brain Damage Lateralization Effect. A meta-analytical approach to an important public health question.

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Host-guest interaction enhanced aggregation-induced emission and its application in cell imaging. We have developed a simple method of fabricating a robust, low-noise nanopore by externally penetrating a nanocavity enclosed in the terminal of a capillary pipet. Adult male progeny of fructose-fed mothers had elevated levels of insulin without a parallel increase in phosphorylation of protein kinase B. It is a major health care problem and associated with inflammation, organ dysfunction and significant mortality. Plant community responses to precipitation and spatial pattern of nitrogen supply in an experimental grassland ecosystem. Heat shock of mouse L cells induces the synthesis of two polypeptides of Mrs 68,000 and 89,000. However, proteoliposomes also exhibited high rates of NBTGR-insensitive uptake of adenosine, making this nucleoside unsuitable for reconstitution studies. Developmental switches in chemokine response profiles during B cell differentiation and maturation.

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To investigate the association of hepatitis C virus (HCV) genotype with glycolipids iron metabolism in Gansu Han population. Cerebral ischemia owing to compression of the brain by swollen temporal muscle used for encephalo-myo-synangiosis in moyamoya disease. Six of 13 calves showed a decreased number of splenocytes, grade II or III, and their red and white pulp regions were unclear. Recently, we developed a new infertility treatment and named it as in-vitro activation (IVA), which enables POF patients to conceive using their own eggs by activation of residual dormant follicles. A hundred and fifty-two patients who were to undergo major zantac 75 dosage orthopaedic surgery were divided into two groups in order to study the value of dextrans administered as adjuvants to oral anticoagulants in the prevention of deep venous thrombosis. However, those who saw the screen described pain more positively (i.e. Stabilization of enzymes is a key factor when using biocatalysis in practice.

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Contralateral subdural effusion secondary to decompressive craniectomy performed in patients with severe traumatic brain injury: incidence, clinical presentations, treatment and outcome. This suggests that rational Lactobacillus strain selection provides a strategy to influence cytokine expression and thereby influence immune responses. orf4 mutants fail to form a detectable circular transfer intermediate, do not show UV induced transfer and show a much reduced general transfer ability. The experimental performance is evaluated with Dodgers loop sensor data set from UCI repository and the performance evaluation outperforms existing work on energy consumption, clustering efficiency, and node drain rate. Micronucleus assay can be used as an easy and consistent marker for genotoxic evaluation in higher risk groups and can be used for better treatment evaluation and prognosis in cases of OSMF and OSCC. Post-traumatic stress syndrome in a large sample of older adults: determinants and quality of life. The management of invasive candidiasis in ICU patients requires the application of a broad range of knowledge and skills that our summarized in our recommendations. These may be some of the explanations for the undertreatment of osteoporosis. The juxtamembrane region surrounding FAs displays a gradient of FA plaque proteins with respect to both concentration and dynamics.

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Homozygous Fkrp(Tyr307Asn) mice showed no discernible phenotype up to 6 months of age, contrary to the severe clinical course observed in patients with the same mutation. subglutinans isolated from mouldy corn seeds harvested in a serious Keshan disease region in Shaanxi Province. Such an approach provides a distinct benefit as compared with conventional laparoscopy, in which multiple entry incisions are required for tools and camera. The phenomenon was detected as early as 72 hours after initiation of theophylline treatment, reaching maximum values at 3-4 weeks and remaining stable for longer than 3 can you drink alcohol if you take abilify months of testing, provided the cells were maintained in the presence of theophylline. Relevant discussions of the embryology, clinical presentation, and the characteristic CT findings of infants with congenital nasolacrimal mucoceles are included. Covariate-adjusted ordinal logistic regression was used to investigate the association of VMS and depression with each item of the Athens Insomnia Scale. The combinations of both N-PLS and U-PLS with residual bilinearization (RBL), achieving the second-order advantage, were satisfactory applied for the simultaneous determination of the main monoamine naphthalene compounds in drinking water, in the presence of a potential interferent without sample pretreatment, even when the later is not modeled in calibration set. By all three determinants, CPR expression was unchanged in aorta from GTN-tolerant rats.

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The aim of this study is to assess the changes of brain tissue oxygen levels in children during the first 24 h following head injury and its correlation with changes of intracranial pressure and clinical outcome. FoxO (mammalian forkhead subclass O) proteins are transcription factors acting downstream of the PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor. The fourth PARAFAC factor (280/380nm) gives us also information about the browning process following a first order kinetic reaction. We conclude that IL-2 abnormalities appear to be most pronounced in RA compared with other inflammatory arthritides and that these changes do not appear to be directly related to serum or SF IL-2 inhibitor levels. Cluster randomized controlled trial of TIA electronic decision flagyl drug name support in primary care. Characteristic clinical, histologic, and ultrastructural features are described. The advantages and disadvantages of the in-situ acetylation/extraction technique are discussed. After injection of horseradish peroxidase into single blastomeres in Xenopus embryos at 2- to 512-cell stages, all of the descendants could be traced and counted at tailbud stages. B7-2 expression on tumor cells is important for the acquisition of cytotoxic T lymphocyte activity by spleen cells from low-dose-melphalan-treated MOPC-315 tumor bearers via a mechanism that requires either B7-1 or B7-2 expression on host antigen-presenting cells.

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